scholarly journals The R22X Mutation of the SDHD Gene in Hereditary Paraganglioma Abolishes the Enzymatic Activity of Complex II in the Mitochondrial Respiratory Chain and Activates the Hypoxia Pathway

2001 ◽  
Vol 69 (6) ◽  
pp. 1186-1197 ◽  
Author(s):  
Anne-Paule Gimenez-Roqueplo ◽  
Judith Favier ◽  
Pierre Rustin ◽  
Jean-Jacques Mourad ◽  
Pierre-François Plouin ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Complex Ii ◽  
Sdhd Gene ◽  
Mitochondrial Respiratory

Impaired energy metabolism in septic hearts of baboons: diminished activities of complex I and complex II of the mitochondrial respiratory chain

Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 24
Author(s):  
Sonata Trumbeckaite ◽  
Kathrin Hertel ◽  
Gilles Durrieu ◽  
Frank Gellerich ◽  
Ursula Müller-Werdan ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Respiratory Chain ◽  
Complex I ◽  
Mitochondrial Respiratory Chain ◽  
Complex Ii ◽  
Impaired Energy Metabolism ◽  
Mitochondrial Respiratory

scholarly journals Inhibitory effects of tetragalloylglucose on the complex II of mitochondrial respiratory chain of Ascaris muscle.

1989 ◽  
Vol 37 (9) ◽  
pp. 2533-2534
Author(s):  
Kiyoshi KONISHI ◽  
Hirokazu ADACHI ◽  
Kiyoshi KITA ◽  
Shinzaburo TAKAMIYA ◽  
Rieko FURUSHIMA ◽  
...  
Keyword(s):  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Inhibitory Effects ◽  
Complex Ii ◽  
Mitochondrial Respiratory

scholarly journals Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Gislaine Z. Réus ◽  
Roberto B. Stringari ◽  
Cinara L. Gonçalves ◽  
Giselli Scaini ◽  
Milena Carvalho-Silva ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Rat Brain ◽  
Respiratory Chain ◽  
Complex I ◽  
Acute Treatment ◽  
Chronic Treatment ◽  
Mitochondrial Respiratory Chain ◽  
Complex Iv ◽  
Complex Ii ◽  
Mitochondrial Respiratory

The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain. After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30 mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg); harmine (15 mg/kg) decreased creatine kinase. In the chronic treatment occurred an increase of creatine kinase with imipramine (20 mg/kg), harmine (5 mg/kg) in the prefrontal with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg) in the striatum. In the acute treatment, the complex I increased in the prefrontal with harmine (15 mg/kg) and in the striatum with harmine (10 mg/kg); the complex II decreased with imipramine (20 and 30 mg/kg) in the striatum; the complex IV increased with imipramine (30 mg/kg) in the striatum. In the chronic treatment, the complex I increased with harmine (5 mg/kg) in the prefrontal; the complex II increased with imipramine (20 mg/kg) in the prefrontal; the complex IV increased with harmine (5 mg/kg) in the striatum. Finally, these findings further support the hypothesis that harmine and imipramine could be involved in mitochondrial function.

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