scholarly journals Comparison of Cutaneous Leishmaniasis Due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: Clinical Findings and Diagnostic Approach

2001 ◽  
Vol 32 (9) ◽  
pp. 1304-1312 ◽  
Author(s):  
G. A. S. Romero ◽  
M. V. de Farias Guerra ◽  
M. G. Paes ◽  
V. d. O. Macedo
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Clinical Findings ◽  
Diagnostic Approach

scholarly journals A Clinical-Based Diagnostic Approach to Cerebellar Atrophy in Children

2021 ◽  
Vol 11 (5) ◽  
pp. 2333
Author(s):  
Claudia Ciaccio ◽  
Chiara Pantaleoni ◽  
Franco Taroni ◽  
Daniela Di Bella ◽  
Stefania Magri ◽  
...  
Keyword(s):  
Muscle Biopsy ◽  
Single Gene ◽  
Brain Mri ◽  
Genetic Defect ◽  
Cerebellar Atrophy ◽  
Chain Complex ◽  
Clinical Findings ◽  
Diagnostic Workup ◽  
Diagnostic Approach ◽  
Disease Definition

Background: Cerebellar atrophy is a neuroradiological definition that categorizes conditions heterogeneous for clinical findings, disease course, and genetic defect. Most of the papers proposing a diagnostic workup for pediatric ataxias are based on neuroradiology or on the literature and experimental knowledge, with a poor participation of clinics in the process of disease definition. Our study aims to offer a different perspective on the way we approach cerebellar atrophy in developmental age, building a clinical-based diagnostic workup to guide molecular diagnosis. Methods: we recruited 52 patients with pediatric-onset cerebellar atrophy and definite disease categorization. Children underwent brain MRI, neurophysiological exams, metabolic investigations, and muscle biopsy with respiratory chain complex study. Single-gene sequencing, next-generation sequencing NGS panels, whole-exome sequencing (WES), and disease-specific techniques have been used to reach genetic confirmation. Results: Brain MRI is the main method of diagnosis, followed by tests on muscle biopsy and peripheral nervous system study. Other exams (e.g., metabolic investigations or evoked potentials) may be useful to narrow the list of diagnostic possibilities. Conclusions: We propose a diagnostic approach to cerebellar atrophy in children based on clinical findings, and support the evidence that a precise phenotypic definition may lead to the formulation of a definite diagnosis or otherwise guide the back phenotyping process derived from large molecular data.

scholarly journals New reports of Australian cutaneous leishmaniasis in Northern Australian macropods

2009 ◽  
Vol 137 (10) ◽  
pp. 1516-1520 ◽  
Author(s):  
A. DOUGALL ◽  
C. SHILTON ◽  
J. LOW CHOY ◽  
B. ALEXANDER ◽  
S. WALTON
Keyword(s):  
Life Cycle ◽  
Cutaneous Leishmaniasis ◽  
Real Time ◽  
Real Time Pcr ◽  
Clinical Findings ◽  
Northern Territory ◽  
Causative Organism ◽  
The World ◽  
Species Specific ◽  
Unique Species

SUMMARYCutaneous leishmaniasis caused by various species of Leishmania is a significant zoonotic disease in many parts of the world. We describe the first cases of Australian cutaneous leishmaniasis in eight northern wallaroos, one black wallaroo and two agile wallabies from the Northern Territory of Australia. Diagnosis was made through a combination of gross appearance of lesions, cytology, histology, direct culture, serology and a species-specific real-time PCR. The causative organism was found to be the same unique species of Leishmania previously identified in red kangaroos. These clinical findings provide further evidence for the continuous transmission of the Australian Leishmania species and its presence highlights the importance of continued monitoring and research into the life-cycle of this parasite.

Clinical findings and management of imported cutaneous leishmaniasis: Report of 14 cases from Austria

2013 ◽  
Vol 11 (2) ◽  
pp. 90-94 ◽  
Author(s):  
W. Poeppl ◽  
C. Oeser ◽  
K. Grabmeier-Pfistershammer ◽  
J. Walochnik ◽  
H. Burgmann
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Clinical Findings

Clinical findings, diagnostic approach, and outcome of Brucella melitensis epididymo-orchitis

2007 ◽  
Vol 57 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Juan D. Colmenero ◽  
Nuria L. Muñoz-Roca ◽  
Pilar Bermudez ◽  
Antonio Plata ◽  
Aurora Villalobos ◽  
...  
Keyword(s):  
Brucella Melitensis ◽  
Clinical Findings ◽  
Diagnostic Approach

scholarly journals Eosinophilic Esophagitis in Children: Clinical Findings and Diagnostic Approach

2020 ◽  
Vol 16 (3) ◽  
pp. 206-214 ◽  
Author(s):  
Arianna De Matteis ◽  
Giuseppe Pagliaro ◽  
Vito Domenico Corleto ◽  
Claudia Pacchiarotti ◽  
Emilio Di Giulio ◽  
...  
Keyword(s):  
Eosinophilic Esophagitis ◽  
Gastrointestinal Symptoms ◽  
Diagnostic Algorithm ◽  
Clinical Findings ◽  
Diagnostic Approach ◽  
Older Children ◽  
Feeding Difficulties ◽  
Diagnostic Endoscopy ◽  
Esophageal Eosinophilia ◽  
Bolus Impaction

: Eosinophilic esophagitis (EoE) is an emerging chronic immune and antigen-mediated clinicopathologic disease. During the last 2 decades, the incidence of this condition in children has increased significantly, thanks to practitioners for creating the awareness and higher use of diagnostic endoscopy. We have analysed paediatric literature on EoE focusing on the epidemiology, pathophysiology, clinical findings and diagnostic approach. : EoE is pathogenically related to a Th2 inflammation characterized by a mixed IgE and non-IgEmediated reaction to food and/or environmental agents. This leads to esophageal dysfunction and remodeling accompanied by subepithelial fibrosis. EoE can be presented with several range of gastrointestinal symptoms, including regurgitation, vomiting, feeding difficulties or feeding refusal in infants and toddlers, as well as heartburn, dysphagia and food bolus impaction in older children and adults. The diagnostic suspicion is based on the presence of chronic symptoms of esophgeal dysfunction and esophageal eosinophilia characterised histologically by a significant eosinophilic infiltration of the oesophageal mucosa (>15 eosinophils per high powered field). In this review, we will provide an update on clinical presentation and diagnostic approach to EoE in children. We emphasized on the relevant aspects of the new clinical condition termed “PPI responsive esophageal eosinophilia”, as entities distinct from EoE and the role of PPI trial in the diagnostic workup, therefore we proposed a new diagnostic algorithm.

scholarly journals Proteinuria: A Guide to Diagnosis and Assessment

2020 ◽  
Vol 4 (1) ◽  
pp. 3-9
Author(s):  
Sasha-Kay D’Aguilar ◽  
◽  
Amith Skandhan ◽  
Keyword(s):  
Renal Failure ◽  
Incidental Finding ◽  
Systemic Disease ◽  
Outpatient Setting ◽  
Clinical Findings ◽  
Diagnostic Approach ◽  
Persistent Proteinuria ◽  
Asymptomatic Patients ◽  
Benign Pathology

Proteinuria is a common incidental finding that physicians face in the inpatient and outpatient setting. Proteinuria may represent a benign pathology in asymptomatic patients, or it can be a sign of significant renal or systemic disease. The latter is usually associated with persistent proteinuria or other clinical findings such as renal failure. This article will focus on the mechanisms, causes and diagnostic approach of proteinuria. Proteinuria is a common incidental finding that physicians face in the inpatient and outpatient setting. Proteinuria may represent a benign pathology in asymptomatic patients, or it can be a sign of significant renal or systemic disease. The latter is usually associated with persistent proteinuria or other clinical findings such as renal failure. This article will focus on the mechanisms, causes and diagnostic approach of proteinuria.

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