scholarly journals A Genetic Factor for Age-Related Cataract: Identification and Characterization of a Novel Galactokinase Variant, “Osaka,” in Asians

2001 ◽  
Vol 68 (4) ◽  
pp. 1036-1042 ◽  
Author(s):  
Yoshiyuki Okano ◽  
Minoru Asada ◽  
Akie Fujimoto ◽  
Akira Ohtake ◽  
Koichiro Murayama ◽  
...  
Keyword(s):  
Genetic Factor ◽  
Age Related ◽  
Identification And Characterization

scholarly journals Identification and characterization of Cardiac Glycosides as senolytic compounds

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Francisco Triana-Martínez ◽  
Pilar Picallos-Rabina ◽  
Sabela Da Silva-Álvarez ◽  
Federico Pietrocola ◽  
Susana Llanos ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Lung Fibrosis ◽  
Cardiac Glycosides ◽  
Experimental Approach ◽  
Therapeutic Interventions ◽  
Electrochemical Gradient ◽  
Age Related ◽  
Identification And Characterization

Abstract Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Cardiac Glycosides (CGs) as a family of compounds with senolytic activity. CGs, by targeting the Na+/K+ATPase pump, cause a disbalanced electrochemical gradient within the cell causing depolarization and acidification. Senescent cells present a slightly depolarized plasma membrane and higher concentrations of H+, making them more susceptible to the action of CGs. These vulnerabilities can be exploited for therapeutic purposes as evidenced by the in vivo eradication of tumors xenografted in mice after treatment with the combination of a senogenic and a senolytic drug. The senolytic effect of CGs is also effective in the elimination of senescence-induced lung fibrosis. This experimental approach allows the identification of compounds with senolytic activity that could potentially be used to develop effective treatments against age-related diseases.

Identification and characterization of aldose reductase in cultured rat mesangial cells

Diabetes ◽  
1992 ◽  
Vol 41 (9) ◽  
pp. 1165-1171 ◽  
Author(s):  
R. Kikkawa ◽  
K. Umemura ◽  
M. Haneda ◽  
N. Kajiwara ◽  
S. Maeda ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Mesangial Cells ◽  
Identification And Characterization
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