scholarly journals Melanocortin-1 Receptor Gene Variants Determine the Risk of Nonmelanoma Skin Cancer Independently of Fair Skin and Red Hair

2001 ◽  
Vol 68 (4) ◽  
pp. 884-894 ◽  
Author(s):  
Maarten T. Bastiaens ◽  
Jeannet A. C. ter Huurne ◽  
Christine Kielich ◽  
Nelleke A. Gruis ◽  
Rudi G.J. Westendorp ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Receptor Gene ◽  
Nonmelanoma Skin Cancer ◽  
Gene Variants ◽  
Melanocortin 1 Receptor ◽  
Red Hair ◽  
Fair Skin

Abstract 2636: Nonmelanoma skin cancer as a marker of a cancer-prone phenotype: Potential role of DNA repair gene variants

2012 ◽  
Author(s):  
Ingo Ruczinski ◽  
Timothy Jorgensen ◽  
Yin Yao Shugart ◽  
Yvette Berthier-Schaad ◽  
Bailey Kessing ◽  
...  
Keyword(s):  
Dna Repair ◽  
Skin Cancer ◽  
Potential Role ◽  
Nonmelanoma Skin Cancer ◽  
Gene Variants ◽  
Repair Gene ◽  
Dna Repair Gene

Contribution of melanocortin-1 receptor gene variants to sporadic cutaneous melanoma risk in a population in central Italy: a case???control study

2006 ◽  
Vol 16 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Maria Concetta Fargnoli ◽  
Emma Altobelli ◽  
Gisela Keller ◽  
Sergio Chimenti ◽  
Heinz H??fler ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Receptor Gene ◽  
Central Italy ◽  
Case Control ◽  
Gene Variants ◽  
Melanoma Risk ◽  
Melanocortin 1 Receptor ◽  
Control Study

Photosensitivity

2010 ◽  
pp. 4665-4671
Author(s):  
Jane McGregor
Keyword(s):  
Skin Cancer ◽  
Human Skin ◽  
Sun Exposure ◽  
Nonmelanoma Skin Cancer ◽  
Sunlight Exposure ◽  
Normal Human Skin ◽  
Normal Individuals ◽  
Normal Human ◽  
Fair Skin

Normal human skin is photosensitive in that it reddens following acute sunlight exposure and tans and thickens following chronic sunlight exposure. Skin cancer, particularly nonmelanoma skin cancer, is also a consequence of high cumulative sun exposure in genetically predisposed normal individuals (predominantly those with fair skin)....

scholarly journals Melanocortin-1 receptor gene variants in four Chinese ethnic populations

Cell Research ◽  
2001 ◽  
Vol 11 (1) ◽  
pp. 81-84 ◽  
Author(s):  
Peng SHI ◽  
Xue Mei LU ◽  
Huai Rong LUO ◽  
Jin-Gong XIANG-YU ◽  
Ya Ping ZHANG
Keyword(s):  
Receptor Gene ◽  
Gene Variants ◽  
Melanocortin 1 Receptor ◽  
Ethnic Populations

Variants of the melanocyte–stimulating hormone receptor gene are associated with red hair and fair skin in humans

1995 ◽  
Vol 11 (3) ◽  
pp. 328-330 ◽  
Author(s):  
Paloma Valverde ◽  
Eugene Healy ◽  
Ian Jackson ◽  
Jonathan L. Rees ◽  
Anthony J. Thody
Keyword(s):  
Hormone Receptor ◽  
Receptor Gene ◽  
Melanocyte Stimulating Hormone ◽  
Red Hair ◽  
Hormone Receptor Gene ◽  
Fair Skin ◽  
Stimulating Hormone

Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair

The Lancet ◽  
2000 ◽  
Vol 355 (9209) ◽  
pp. 1072-1073 ◽  
Author(s):  
Eugene Healy ◽  
Niamh Flannagan ◽  
Amanda Ray ◽  
Carole Todd ◽  
Ian J Jackson ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Melanocortin 1 Receptor ◽  
Red Hair ◽  
Sun Sensitivity

scholarly journals Anesthetic Requirement Is Increased in Redheads

2004 ◽  
Vol 101 (2) ◽  
pp. 279-283 ◽  
Author(s):  
Edwin B. Liem ◽  
Chun-Ming Lin ◽  
Mohammad-Irfan Suleman ◽  
Anthony G. Doufas ◽  
Ronald G. Gregg ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Volatile Anesthetic ◽  
Melanocortin 1 Receptor ◽  
Regression Curves ◽  
Red Hair ◽  
Sample Test ◽  
Inhalational Anesthetic ◽  
Anesthetic Requirement ◽  
End Tidal ◽  
Compound Heterozygotes

Background Age and body temperature alter inhalational anesthetic requirement; however, no human genotype is associated with inhalational anesthetic requirement. There is an anecdotal impression that anesthetic requirement is increased in redheads. Furthermore, red hair results from distinct mutations of the melanocortin-1 receptor. Therefore, the authors tested the hypothesis that the requirement for the volatile anesthetic desflurane is greater in natural redheaded than in dark-haired women. Methods The authors studied healthy women with bright red (n = 10) or dark (n = 10) hair. Blood was sampled for subsequent analyses of melanocortin-1 receptor alleles. Anesthesia was induced with sevoflurane and maintained with desflurane randomly set at an end-tidal concentration between 5.5 and 7.5%. After an equilibration period, a noxious electrical stimulation (100 Hz, 70 mA) was transmitted through bilateral intradermal needles. If the volunteer moved in response to stimulation, desflurane was increased by 0.5%; otherwise, it was decreased by 0.5%. This was continued until volunteers "crossed over" from movement to nonmovement (or vice versa) four times. Individual logistic regression curves were used to determine desflurane requirement (P50). Desflurane requirements in the two groups were compared using Mann-Whitney nonparametric two-sample test; P < 0.05 was considered statistically significant. Results The desflurane requirement in redheads (6.2 vol% [95% CI, 5.9-6.5]) was significantly greater than in dark-haired women (5.2 vol% [4.9-5.5]; P = 0.0004). Nine of 10 redheads were either homozygous or compound heterozygotes for mutations on the melanocortin-1 receptor gene. Conclusions Red hair seems to be a distinct phenotype linked to anesthetic requirement in humans that can also be traced to a specific genotype.

Red hair, fair skin and melanoma - melanocortin 1 receptor

2008 ◽  
Vol 13 (9) ◽  
pp. 568-568
Author(s):  
J. L. Rees ◽  
K. Waterston ◽  
L. Naysmith ◽  
C. Oh ◽  
A. Hennessy ◽  
...  
Keyword(s):  
Melanocortin 1 Receptor ◽  
Red Hair ◽  
Fair Skin

scholarly journals Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi

2009 ◽  
Vol 220 (3) ◽  
pp. 640-654 ◽  
Author(s):  
Berta L. Sánchez-Laorden ◽  
Cecilia Herraiz ◽  
Julio C. Valencia ◽  
Vincent J. Hearing ◽  
Celia Jiménez-Cervantes ◽  
...  
Keyword(s):  
Steady State ◽  
Skin Cancer ◽  
Melanocortin 1 Receptor ◽  
Red Hair ◽  
Mutant Forms
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