scholarly journals Simultaneous Multiorgan Presence of Human Herpesvirus 8 and Restricted Lymphotropism of Epstein‐Barr Virus DNA Sequences in a Human Immunodeficiency Virus–Negative Immunodeficient Infant

2001 ◽  
Vol 183 (2) ◽  
pp. 338-342 ◽  
Author(s):  
Pablo Sánchez‐Velasco ◽  
Javier G. Ocejo‐Vinyals ◽  
Reyes Flores ◽  
José J. Gómez‐Román ◽  
María‐José Lozano ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Dna Sequences ◽  
Epstein Barr Virus ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr

scholarly journals Epstein‐Barr Virus and Human Herpesvirus 8 Prevalence in Human Immunodeficiency Virus‐Associated Oral Mucosal Lesions

1997 ◽  
Vol 175 (6) ◽  
pp. 1324-1332 ◽  
Author(s):  
Jennifer Webster‐Cyriaque ◽  
Rachel H. Edwards ◽  
Evelyn B. Quinlivan ◽  
Lauren Patton ◽  
David Wohl ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Epstein Barr Virus ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions ◽  
Epstein Barr

Association of Primary Pleural Effusion Lymphoma of T-Cell Origin and Human Herpesvirus 8 in a Human Immunodeficiency Virus–Seronegative Man

2001 ◽  
Vol 125 (9) ◽  
pp. 1246-1248 ◽  
Author(s):  
Emmanuèle Lechapt-Zalcman ◽  
Dominique Challine ◽  
Marie-Hélène Delfau-Larue ◽  
Corinne Haioun ◽  
Dominique Desvaux ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Dna Sequences ◽  
Primary Effusion Lymphoma ◽  
Polymerase Chain Reaction Amplification ◽  
Human Herpesvirus ◽  
Body Cavity ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Immunodeficiency Virus

Abstract We describe a case of an 87-year-old human immunodeficiency virus (HIV)–negative man who developed a primary pleural lymphoma without any identifiable tumor mass associated with human herpesvirus 8 (HHV-8) infection. A large T-cell lymphoma was diagnosed based on morphologic, immunophenotypic, and molecular findings. The HHV-8 DNA sequences were detected using specific polymerase chain reaction amplification in the lymphomatous effusion. Study of the patient's serum confirmed the HHV-8 infection. This case report displays the characteristic features of HHV-8–related body cavity-based lymphoma/primary effusion lymphoma previously reported in HIV-seronegative patients, except that it is of T-cell origin. Whether this case may be included or not within the primary effusion lymphoma entity, the association of a pleural T-cell non-Hodgkin lymphoma with HHV-8 infection raises the question of the possible occurrence of T cells as the target of malignant transformation associated with HHV-8 infection.

scholarly journals Is there a relationship between the detection of human herpesvirus 8 and Epstein–Barr virus in Waldeyer's ring tissues?

2006 ◽  
Vol 70 (11) ◽  
pp. 1923-1927 ◽  
Author(s):  
Cristiano Aparecido Chagas ◽  
Luiza Hayashi Endo ◽  
Washington Luís Conrado dos-Santos ◽  
Glauce Aparecida Pinto ◽  
Eulália Sakano ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Barr Virus ◽  
Waldeyer’S Ring ◽  
Epstein Barr

Proportion Positive for Epstein-Barr Virus, Cytomegalovirus, Human Herpesvirus 6, Toxoplasma, and Human Immunodeficiency Virus Types 1 and 2 in Heterophile-Negative Patients With an Absolute Lymphocytosis or an Instrument-Generated Atypical Lymphocyte Flag

2000 ◽  
Vol 124 (9) ◽  
pp. 1324-1330 ◽  
Author(s):  
Yotis F. Tsaparas ◽  
Malcolm L. Brigden ◽  
Richard Mathias ◽  
Eva Thomas ◽  
Janet Raboud ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Epstein Barr Virus ◽  
Human Herpesvirus ◽  
Atypical Lymphocyte ◽  
Human Herpesvirus 6 ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Testing Algorithm ◽  
Viral Serology

Abstract Objectives.—To determine the proportion of patients with evidence of an acute infection due to Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), Toxoplasma, or human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) in heterophile-negative patients with an absolute lymphocytosis or an instrument-generated atypical lymphocyte flag, and to develop a cost-effective testing algorithm for managing such heterophile-negative patients. Design.—We conducted a prospective investigation of 70 selected outpatients who tested negative for heterophile antibody in association with an absolute lymphocytosis or instrument-generated atypical lymphocyte flag. The control population consisted of 50 patients who were heterophile negative and had a normal absolute lymphocyte count and no instrument-generated atypical lymphocyte flag. Setting.—A large outpatient laboratory system. Intervention.—Viral serology for HHV-6 was performed by immunofluorescence, and all other serologies were performed by enzyme-linked immunoassay. All testing was for immunoglobulin (Ig) M antibodies, except in the case of HIV. Results.—The proportion of study patients positive for EBV was 40% (28/70); for CMV, 39% (27/70); for HHV-6, 25% (16/65); for Toxoplasma, 3% (2/70); and for HIV, 0% (0/70). All 50 control patients were negative for EBV IgM antibodies. When patients with more than 1 positive viral test were excluded from analysis, positivity was 20% (9/45) for EBV, 22% (10/45) for CMV, 9% (4/45) for HHV-6, and 2% (1/45) for Toxoplasma. Utilizing hypothesis-generating logistic regression models, Downey type II atypical lymphocytes were significantly associated with EBV positivity (P = .006), while Downey type III lymphocytes were significantly associated with HHV-6 positivity (P = .016), and there was a trend for the association of Downey type I lymphocytes with CMV positivity (P = .097). Conclusions.—A positive viral serology was identified in 70% of study patients. Multiple positive serologies complicate establishing a definitive diagnosis. Potential cost savings may be associated with the use of an appropriate testing algorithm.

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