scholarly journals The GB Virus C/Hepatitis G Virus Replicates in Hepatocytes without Causing Liver Disease in Healthy Blood Donors

2000 ◽  
Vol 182 (6) ◽  
pp. 1756-1760 ◽  
Author(s):  
Robert Halasz ◽  
Matti Sällberg ◽  
Suzana Lundholm ◽  
Göran Andersson ◽  
Björn Lager ◽  
...  
Keyword(s):  
Liver Disease ◽  
Blood Donors ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Hepatitis G ◽  
Virus C

GB virus C/hepatitis G virus infection among Japanese patients with chronic liver disease and blood donors

1996 ◽  
Vol 46 (1-2) ◽  
pp. 89-93 ◽  
Author(s):  
Etsuro Orito ◽  
Masashi Mizokami ◽  
Tatsunori Nakano ◽  
Ron-Ron Wu ◽  
Kun Cao ◽  
...  
Keyword(s):  
Liver Disease ◽  
Virus Infection ◽  
Chronic Liver Disease ◽  
Blood Donors ◽  
Japanese Patients ◽  
Chronic Liver ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Hepatitis G ◽  
Virus C

Infection with GB virus C/hepatitis G virus among blood donors and hemophiliacs in Martinique, a Caribbean Island

1999 ◽  
Vol 59 (2) ◽  
pp. 160-163 ◽  
Author(s):  
R. C�saire ◽  
J. Martial ◽  
H. Maier ◽  
B. Kerob-Bauchet ◽  
O. Bera ◽  
...  
Keyword(s):  
Blood Donors ◽  
Caribbean Island ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Hepatitis G ◽  
Virus C

scholarly journals Prevalence of GB Virus C/Hepatitis G Virus Infection among Various Populations in Surabaya, Indonesia, and Identification of Novel Groups of Sequence Variants

2000 ◽  
Vol 38 (2) ◽  
pp. 662-668 ◽  
Author(s):  
Retno Handajani ◽  
Soetjipto ◽  
Maria Inge Lusida ◽  
Purnomo Suryohudoyo ◽  
Pangestu Adi ◽  
...  
Keyword(s):  
Viral Genome ◽  
Blood Donors ◽  
Maintenance Hemodialysis ◽  
Virus Surface ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Group 4 ◽  
Hepatitis G ◽  
Group 5 ◽  
Virus C

A molecular epidemiological study was performed to investigate the prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among various populations in Surabaya, Indonesia. The prevalence of GBV-C/HGV RNA, determined by reverse transcription-PCR for a portion of the NS3 region of the viral genome, was 2.7% (4 of 150) among randomly collected blood donor sera, which were all negative for both hepatitis B virus surface antigen and antibodies against hepatitis C virus (HCV). On the other hand, the prevalence among anti-HCV-positive blood donors was 17.8% (13 of 73), with the ratio being significantly higher than that observed with the anti-HCV-negative blood donors (P < 0.001). A high prevalence of GBV-C/HGV infection was also observed among patients with chronic liver disease, such as chronic hepatitis (5.7%), liver cirrhosis (11.5%), and hepatocellular carcinoma (7.0%), and patients on maintenance hemodialysis (29.0%). No correlation was observed between GBV-C/HGV viremia and serum alanine aminotransferase levels in the populations tested, suggesting the possibility that GBV-C/HGV does not cause apparent liver injury. Phylogenetic analysis of sequences of a portion of the 5′ untranslated region and the E1 region of the viral genome identified, in addition to a previously reported then novel group of GBV-C/HGV variants (group 4), another novel group of variants (group 5). This result suggests that GBV-C/HGV can be classified into at least five genetic groups. GBV-C/HGV isolates of group 4 and group 5 were each shown to comprise approximately 40% of the total Indonesian isolates.

scholarly journals Prevalence of GB Virus C (Also Called Hepatitis G Virus) Markers in Norwegian Blood Donors

2000 ◽  
Vol 38 (7) ◽  
pp. 2584-2590 ◽  
Author(s):  
Svein Arne Nordbø ◽  
Sidsel Krokstad ◽  
Per Winge ◽  
Finn Egil Skjeldestad ◽  
Are B. Dalen
Keyword(s):  
Medical Records ◽  
Blood Donors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sequence Analyses ◽  
Serum Samples ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Reverse Transcription Pcr ◽  
Hepatitis G ◽  
Virus C

GB virus C (GBV-C), also called hepatitis G virus (HGV), occurs worldwide, but the clinical significance of this virus is still unclear. Plasma samples from 1,001 blood donors were tested by reverse transcription PCR using primers from the NS5 region and by a commercial enzyme-linked immunosorbent assay (ELISA) for the detection of immunoglobulin G antibodies against the putative envelope of HGV (anti-HGV E2). GBV-C/HGV RNA was present in the plasma from 2.5% of the blood donors, and anti-HGV E2 antibodies could be detected in 10.5% of the samples. Only one of the blood donors with viremia had elevated levels of alanine aminotransferase. Among ELISA-positive donors, there was a significantly higher percentage (16.5%) of individuals who had been treated by acupuncture than individuals who had not been given this treatment (9.4%). No other variables showed significant differences. Screening of medical records from 401 recipients of blood from PCR-positive donors revealed no association with liver disease. Four of 12 partners (33%) were HGV RNA positive, and sequence analyses of the strains showed that four of the couples probably were infected with the same strains, while strains from different couples were not identical. Anti-HGV E2 antibodies were detected in serum samples from four other partners. The prevalence of GBV-C/HGV among blood donors in our region is dramatically higher than the prevalence of hepatitis C virus (0.03%).

GB virus C/Hepatitis G virus infection in Saudi Arabian blood donors and patients with cryptogenic hepatitis

2000 ◽  
Vol 145 (1) ◽  
pp. 73-84 ◽  
Author(s):  
M. N. Al-Ahdal ◽  
M. A. Rezeig ◽  
G. Kessie ◽  
F. Chaudhry ◽  
F. J. Al-Shammary
Keyword(s):  
Virus Infection ◽  
Blood Donors ◽  
Saudi Arabian ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Cryptogenic Hepatitis ◽  
Hepatitis G ◽  
Virus C

GB virus C/hepatitis G virus infection in Indian blood donors and high-risk groups

2004 ◽  
Vol 30 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Mayura M. Desai ◽  
Ramprasad B. Pal ◽  
Dushyant D. Banker
Keyword(s):  
High Risk ◽  
Virus Infection ◽  
Blood Donors ◽  
Risk Groups ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Hepatitis G ◽  
Virus C ◽  
Indian Blood

scholarly journals A High Prevalence of Serum GB Virus C/Hepatitis G Virus RNA in Children with and without Liver Disease

1999 ◽  
Vol 28 (3) ◽  
pp. 537-540 ◽  
Author(s):  
Robert Halasz ◽  
Björn Fischler ◽  
Antal Nemeth ◽  
Suzana Lundholm ◽  
Matti Sällberg
Keyword(s):  
Liver Disease ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Virus Rna ◽  
High Prevalence ◽  
Hepatitis G ◽  
Virus C
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