scholarly journals Changes in the Composition of Circulating CD8+T Cell Subsets during Acute Epstein‐Barr and Human Immunodeficiency Virus Infections in Humans

2000 ◽  
Vol 182 (2) ◽  
pp. 451-458 ◽  
Author(s):  
Marijke Th. L. Roos ◽  
René A. W. van Lier ◽  
Dörte Hamann ◽  
Gerlinde J. Knol ◽  
Irma Verhoofstad ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
Virus Infections ◽  
Immunodeficiency Virus ◽  
Epstein Barr

scholarly journals T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus

2020 ◽  
Vol 222 (2) ◽  
pp. 252-262 ◽  
Author(s):  
Samuel S Bailin ◽  
Kathleen A McGinnis ◽  
Wyatt J McDonnell ◽  
Kaku So-Armah ◽  
Melissa Wellons ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
T Lymphocyte Subsets ◽  
Immunodeficiency Virus ◽  
Memory Cd4 T Cells ◽  
Hiv Negative

Abstract Background A higher proportion of circulating memory CD4+ T cells is associated with prevalent diabetes mellitus in the general population. Given the broad changes in adaptive immunity, including memory T-cell expansion, and rising prevalence of diabetes in the human immunodeficiency virus (HIV) population, we assessed whether similar relationships were present in persons with HIV (PWH). Methods Multiple CD4+ and CD8+ T-cell subsets were measured by flow cytometry, and prevalent diabetes cases were adjudicated by 2 physicians for PWH and HIV-negative participants in the Veterans Aging Cohort Study. Multivariable logistic regression models evaluated the association of T-cell subsets and diabetes stratified by HIV status, adjusted for cytomegalovirus serostatus and traditional risk factors. Results Among 2385 participants (65% PWH, 95% male, 68% African American), higher CD45RO+ memory CD4+ T cells and lower CD38+ CD4+ T cells were associated with prevalent diabetes, and had a similar effect size, in both the PWH and HIV-negative (P ≤ .05 for all). Lower CD38+CD8+ T cells were also associated with diabetes in both groups. Conclusions The CD4+ and CD8+ T-cell subsets associated with diabetes are similar in PWH and HIV-negative individuals, suggesting that diabetes in PWH may be related to chronic immune activation.

scholarly journals High-Potency Human Immunodeficiency Virus Vaccination Leads to Delayed and Reduced CD8+ T-Cell Expansion but Improved Virus Control

2005 ◽  
Vol 79 (15) ◽  
pp. 10059-10062 ◽  
Author(s):  
Miles P. Davenport ◽  
Lei Zhang ◽  
Ansuman Bagchi ◽  
Arthur Fridman ◽  
Tong-Ming Fu ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Cell Expansion ◽  
Virus Infections ◽  
Significant Delay ◽  
Viral Kinetics ◽  
Cell Numbers ◽  
Viral Loads ◽  
Immunodeficiency Virus ◽  
T Cell Expansion

ABSTRACT CD8+ T lymphocytes are thought to play an important role in the control of acute and chronic human immunodeficiency virus infections. However, there is a significant delay between infection and the first observed increase in virus-specific CD8+ T-cell numbers. Prior to this time, viral kinetics are not significantly different between controls and vaccinees. Surprisingly, higher initial virus-specific CD8+ T-cell numbers lead to a longer delay prior to initial CD8+ T-cell expansion, and slower CD8+ T-cell increases. Nevertheless, higher initial CD8+ T-cell numbers were associated with reduced peak and chronic viral loads and reduced CD4+ T-cell depletion.

scholarly journals Alterations in T Cell Subsets in Human Immunodeficiency Virus–Infected Adults with Co-infections in Southern Mozambique

2011 ◽  
Vol 85 (4) ◽  
pp. 776-781 ◽  
Author(s):  
Denise Naniche ◽  
Pedro Alonso ◽  
Tacilta Nhampossa ◽  
Catarina David ◽  
Emilio Letang ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
T Cell Subsets ◽  
Immunodeficiency Virus

scholarly journals Comparison of Microcapillary Cytometry Technology and Flow Cytometry for CD4+ and CD8+ T-Cell Estimation

2005 ◽  
Vol 12 (8) ◽  
pp. 1006-1009 ◽  
Author(s):  
A. J. Kandathil ◽  
R. Kannangai ◽  
S. David ◽  
G. Nithyanandam ◽  
S. Solomon ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Human Immunodeficiency Virus ◽  
T Cells ◽  
T Cell ◽  
Coefficient Of Variation ◽  
Cd8 T Cell ◽  
Healthy Individuals ◽  
San Jose ◽  
Becton Dickinson ◽  
Immunodeficiency Virus

ABSTRACT An alternative technology for the estimation of T cells based on a microcapillary technique (Guava Technologies, Hayward, CA) was compared to FACSCount (Becton Dickinson, San Jose, CA). Samples from 51 human immunodeficiency virus-infected and 21 healthy individuals were tested. The correlation (r) of the two systems for CD4+ T cells was 0.994, and the coefficient of variation was 6.5%, establishing equable performance between the two technologies.

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