scholarly journals Prognostic Value of Cytokine Concentrations (Tumor Necrosis Factor–α, Interleukin‐6, and Interleukin‐10) and Clinical Parameters in Severe Melioidosis

2000 ◽  
Vol 181 (2) ◽  
pp. 621-625 ◽  
Author(s):  
Andrew J. H. Simpson ◽  
Michael D. Smith ◽  
Gerrit Jan Weverling ◽  
Yupin Suputtamongkol ◽  
Brian J. Angus ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Clinical Parameters ◽  
Factor Α ◽  
Necrosis Factor

Interleukin-10 inhibits polymethylmethacrylate particle induced interleukin-6 and tumor necrosis factor-α release by human monocyte/macrophages in vitro

Biomaterials ◽  
2001 ◽  
Vol 22 (15) ◽  
pp. 2067-2073 ◽  
Author(s):  
Michael C.D. Trindade ◽  
Martin Lind ◽  
Yasuharu Nakashima ◽  
Doohoon Sun ◽  
Stuart B. Goodman ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Human Monocyte ◽  
Interleukin 10 ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor α, interleukin-6 and interleukin-10 polymorphisms in preeclampsia

2010 ◽  
Vol 36 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Pervin Vural ◽  
Sevgin Degirmencioglu ◽  
Neslihan Y. Saral ◽  
Ayse Demirkan ◽  
Cemil Akgul ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Human Alzheimer and Inflammation Biomarkers after Anesthesia and Surgery

2011 ◽  
Vol 115 (4) ◽  
pp. 727-732 ◽  
Author(s):  
Junxia X. Tang ◽  
Dimitry Baranov ◽  
Mary Hammond ◽  
Leslie M. Shaw ◽  
Maryellen F. Eckenhoff ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Amyloid Β ◽  
Interleukin 10 ◽  
Neuroinflammatory Response ◽  
Total Tau ◽  
Factor Α ◽  
Necrosis Factor

Background The prevalence of postoperative cognitive disturbance, coupled with growing in vitro, cell, and animal evidence suggesting anesthetic effects on neurodegeneration, calls for additional study of the interaction between surgical care and Alzheimer neuropathology. The authors studied human cerebrospinal fluid (CSF) biomarkers during surgery. Methods Eleven patients undergoing idiopathic nasal CSF leak correction were admitted to this Institutional Review Board-approved study. Lumbar subarachnoid catheters were placed before the procedure. Anesthesia was total intravenous propofol or remifentanil or inhalational sevoflurane, depending on provider choice. CSF samples were taken after catheter placement (base), at procedure end (0 h), and then at 6, 24, and 48 h. CSF was analyzed using xMAP Luminex immunoassay (Luminex, Austin, TX). Results Of the 11 patients (age range, 53 ± 6 yr), 8 were women; 4 received intravenous anesthesia, 6 sevoflurane, and 1 mixed. Procedures lasted 6.4 ± 2 h. Mean CSF amyloid-β(1-42) remained unchanged, but total-tau and phosphorylated-tau181P increased progressively until at least 48 h. Total-tau, phosphorylated-tau, or amyloid-β(1-42) concentrations were not different between anesthetic groups. CSF interleukin-10, S100Beta, and tumor necrosis factor α were increased similarly in both anesthetic groups at 24 h, but interleukin-6 was increased more in the inhalational group. Conclusion These data indicate a robust neuroinflammatory response, including not only the usual markers (interleukin-6, tumor necrosis factor α, interleukin-10), but also S100Beta and tau, markers of injury. The total-tau/amyloid-β(1-42) ratio increased in a pattern consistent with Alzheimer disease, largely because of an increase in total-tau rather than a decline in amyloid-β(1-42). The differences in CSF interleukin-6 concentrations suggest that anesthetic management may make a difference in neuroinflammatory response.

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