scholarly journals Invasive Group A Streptococcal Disease in The Netherlands: Evidence for a Protective Role of Anti–Exotoxin A Antibodies

2000 ◽  
Vol 181 (2) ◽  
pp. 631-638 ◽  
Author(s):  
Ellen M. Mascini ◽  
Margriet Jansze ◽  
Joop F. P. Schellekens ◽  
James M. Musser ◽  
Joop A. J. Faber ◽  
...  
Keyword(s):  
The Netherlands ◽  
Protective Role ◽  
Exotoxin A ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Group A

Role of Streptolysin O in a Mouse Model of Invasive Group A Streptococcal Disease

2000 ◽  
Vol 68 (11) ◽  
pp. 6384-6390 ◽  
Author(s):  
Brandi Limbago ◽  
Vikram Penumalli ◽  
Brian Weinrick ◽  
June R. Scott
Keyword(s):  
Mouse Model ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Streptolysin O ◽  
Group A

scholarly journals Long-term surveillance of invasive group A streptococcal disease in The Netherlands, 1994–2003

2005 ◽  
Vol 11 (3) ◽  
pp. 226-231 ◽  
Author(s):  
B.J.M. Vlaminckx ◽  
W. van Pelt ◽  
L.M. Schouls ◽  
A. van Silfhout ◽  
E.M. Mascini ◽  
...  
Keyword(s):  
The Netherlands ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Group A

scholarly journals Invasive Group A Streptococcal Disease: Management and Chemoprophylaxis

2010 ◽  
Vol 21 (3) ◽  
pp. 115-118 ◽  
Author(s):  
UD Allen ◽  
DL Moore
Keyword(s):  
Disease Management ◽  
Management Strategies ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Group A

Given the potentially devastating consequences of severe invasive group A streptococcal disease, attention has been directed toward the role of chemoprophylaxis and the optimization of management strategies. In response to this issue, Canadian guidelines were previously developed. However, the uptake of these recommendations is variable across Canada. The present document summarizes key components of the recommendations for use by Canadian physicians. The importance of penicillin in the treatment of group A streptococcal disease is reaffirmed, and the role of clindamycin is discussed. In addition, in situations in which chemoprophylaxis may be considered, the preferred agents are summarized.

High burden of invasive group A streptococcal disease in the Northern Territory of Australia

2015 ◽  
Vol 144 (5) ◽  
pp. 1018-1027 ◽  
Author(s):  
R. BOYD ◽  
M. PATEL ◽  
B. J. CURRIE ◽  
D. C. HOLT ◽  
T. HARRIS ◽  
...  
Keyword(s):  
Indigenous Population ◽  
Case Series ◽  
Northern Territory ◽  
Molecular Characteristics ◽  
Streptococcal Toxic Shock Syndrome ◽  
Public Health Response ◽  
Diverse Range ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Group A

SUMMARYAlthough the incidence of invasive group A streptococcal disease in northern Australia is very high, little is known of the regional epidemiology and molecular characteristics. We conducted a case series of Northern Territory residents reported between 2011 and 2013 withStreptococcus pyogenesisolates from a normally sterile site. Of the 128 reported episodes, the incidence was disproportionately high in the Indigenous population at 69·7/100 000 compared to 8·8/100 000 in the non-Indigenous population. Novel to the Northern Territory is the extremely high incidence in haemodialysis patients of 2205·9/100 000 population; and for whom targeted infection control measures could prevent transmission. The incidences in the tropical north and semi-arid Central Australian regions were similar. Case fatality was 8% (10/128) and streptococcal toxic shock syndrome occurred in 14 (11%) episodes. Molecular typing of 82 isolates identified 28emmtypes, of which 63 (77%) were represented by fouremmclusters. Typing confirmed transmission between infant twins. While the diverse range ofemmtypes presents a challenge for effective coverage by vaccine formulations, the limited number ofemmclusters raises optimism should cluster-specific cross-protection prove efficacious. Further studies are required to determine effectiveness of chemoprophylaxis for contacts and to inform public health response.

scholarly journals Invasive group A, C and G streptococcal disease in western Norway: virulence gene profiles, clinical features and outcomes

2011 ◽  
Vol 17 (3) ◽  
pp. 358-364 ◽  
Author(s):  
B.R. Kittang ◽  
T. Bruun ◽  
N. Langeland ◽  
H. Mylvaganam ◽  
M. Glambek ◽  
...  
Keyword(s):  
Clinical Features ◽  
Virulence Gene ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Gene Profiles ◽  
Western Norway ◽  
Group A

Risk Factors in the Pathogenesis of Invasive Group A Streptococcal Infections: Role of Protective Humoral Immunity

1999 ◽  
Vol 67 (4) ◽  
pp. 1871-1877 ◽  
Author(s):  
Hesham Basma ◽  
Anna Norrby-Teglund ◽  
Yajaira Guedez ◽  
Allison McGeer ◽  
Donald E. Low ◽  
...  
Keyword(s):  
Risk Factors ◽  
Humoral Immunity ◽  
Streptococcal Infections ◽  
Invasive Group ◽  
Group A
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