scholarly journals Severity of Tuberculosis in Mice is Linked to Distal Chromosome 3 and Proximal Chromosome 9

1999 ◽  
Vol 180 (1) ◽  
pp. 150-155 ◽  
Author(s):  
Catharina Lavebratt ◽  
Alexander S. Apt ◽  
Boris V. Nikonenko ◽  
Martin Schalling ◽  
Erwin Schurr
Keyword(s):  
Chromosome 9 ◽  
Chromosome 3 ◽  
Distal Chromosome

Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9

1987 ◽  
Vol 13 (6) ◽  
pp. 689-693 ◽  
Author(s):  
Christina T. Teng ◽  
Brian T. Pentecost ◽  
Angus Marshall ◽  
Amy Solomon ◽  
Barbara H. Bowman ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 9 ◽  
Chromosome 3 ◽  
Human Chromosome 3

scholarly journals Chromosome 3q21 abnormalities associated with hyperactive thrombopoiesis in acute blastic transformation of chronic myeloid leukemia

Blood ◽  
1986 ◽  
Vol 68 (3) ◽  
pp. 652-657 ◽  
Author(s):  
R Bernstein ◽  
A Bagg ◽  
M Pinto ◽  
D Lewis ◽  
B Mendelow
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Chromosome Translocation ◽  
Chromosome 9 ◽  
Chromosome 3 ◽  
Acute Megakaryoblastic Leukemia ◽  
Blastic Transformation ◽  
Megakaryoblastic Leukemia ◽  
Platelet Counts

Abstract Two patients with acute blastic transformation of chronic myeloid leukemia (CML) associated with strikingly elevated platelet counts showed abnormalities of chromosome 3q in addition to the standard Philadelphia (Ph1) chromosome translocation. The first patient had an inversion of chromosome 3 (q21q26) cytologically identical to an inversion 3 previously reported in de novo acute megakaryoblastic leukemia, and the second patient showed a translocation between chromosome 3q and the chromosome 9 homologue not involved in the Ph1 translocation, [t(3;9)(q21;q34)]. Previous studies had incriminated either 3q21 or 3q26 as the locus for a regulatory thrombopoietic gene, but the current study suggests that 3q21 is the relevant site.

Mapping colitis susceptibility in mouse models: distal chromosome 3 contains major loci related to Cdcs1

2013 ◽  
Vol 45 (20) ◽  
pp. 925-930 ◽  
Author(s):  
Manuela Buettner ◽  
André Bleich
Keyword(s):  
Mouse Models ◽  
Genetic Mutation ◽  
Chromosome 3 ◽  
Environmental Interactions ◽  
Causative Factors ◽  
Distal Chromosome ◽  
Pathogen Control ◽  
Inflammatory Bowel ◽  
Trait Locus ◽  
Relevant Factors

Inflammatory bowel disease (IBD) summarizes a group of chronic intestinal disorders with Crohn's disease and ulcerative colitis being most prominent. Though much effort is put into identification of causative factors, its etiology is still not understood. Risk factors for disease development include genetic predisposition and environmental triggers. Crucial for identification and analysis of relevant factors are mouse models. Experimental IBD in mice occurs spontaneously or is induced by chemicals, cell transfer, pathogens, or genetic mutation. These models were utilized for analyzing genetic contribution to disease and genotype-environmental interactions. In these studies, a variety of modifier loci were identified, thereby demonstrating the complexity of disease. A major contribution of distal chromosome 3 was independently replicated in several studies. The first colitogenic QTL in this region was detected using the IL-10-deficient mouse model and called cytokine deficiency-induced colitis susceptibility ( Cdcs) 1. This quantitative trait locus contains at least three subintervals with independent genetic factors. This locus or defined subintervals were replicated in at least seven studies, using models based on dysregulation of innate or adaptive immunity or pathogen control. In this review we illustrate the various models used for genetic mapping of susceptibility to experimental IBD and display Cdcs1-related loci as well as the mechanism of their contribution identified so far.

The mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein maps to distal Chromosome 9

1996 ◽  
Vol 7 (11) ◽  
pp. 847-849 ◽  
Author(s):  
A. S. McCallion ◽  
J -L. Guénet ◽  
P. Montague ◽  
I. R. Griffiths ◽  
A. Savioz ◽  
...  
Keyword(s):  
Basic Protein ◽  
Mouse Gene ◽  
Chromosome 9 ◽  
Distal Chromosome

scholarly journals Chromosome 3q21 abnormalities associated with hyperactive thrombopoiesis in acute blastic transformation of chronic myeloid leukemia

Blood ◽  
1986 ◽  
Vol 68 (3) ◽  
pp. 652-657
Author(s):  
R Bernstein ◽  
A Bagg ◽  
M Pinto ◽  
D Lewis ◽  
B Mendelow
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Chromosome Translocation ◽  
Chromosome 9 ◽  
Chromosome 3 ◽  
Acute Megakaryoblastic Leukemia ◽  
Blastic Transformation ◽  
Megakaryoblastic Leukemia ◽  
Platelet Counts

Two patients with acute blastic transformation of chronic myeloid leukemia (CML) associated with strikingly elevated platelet counts showed abnormalities of chromosome 3q in addition to the standard Philadelphia (Ph1) chromosome translocation. The first patient had an inversion of chromosome 3 (q21q26) cytologically identical to an inversion 3 previously reported in de novo acute megakaryoblastic leukemia, and the second patient showed a translocation between chromosome 3q and the chromosome 9 homologue not involved in the Ph1 translocation, [t(3;9)(q21;q34)]. Previous studies had incriminated either 3q21 or 3q26 as the locus for a regulatory thrombopoietic gene, but the current study suggests that 3q21 is the relevant site.

scholarly journals Gapless assembly of maize chromosomes using long read technologies

2020 ◽  
Author(s):  
Jianing Liu ◽  
Arun S. Seetharam ◽  
Kapeel Chougule ◽  
Shujun Ou ◽  
Kyle W. Swentowsky ◽  
...  
Keyword(s):  
Genome Assembly ◽  
Meiotic Drive ◽  
Chromosome 9 ◽  
Chromosome 3 ◽  
Maize Genome ◽  
Optical Map ◽  
Long Read

AbstractCreating gapless telomere-to-telomere assemblies of complex genomes is one of the ultimate challenges in genomics. We used long read technologies and an optical map based approach to produce a maize genome assembly composed of only 63 contigs. The B73-Ab10 genome includes gapless assemblies of chromosome 3 (236 Mb) and chromosome 9 (162 Mb), multiple highly repetitive centromeres and heterochromatic knobs, and 53 Mb of the Ab10 meiotic drive haplotype.

Alopecia and male infertility in oligotriche mutant mice are caused by a deletion on distal chromosome 9

2008 ◽  
Vol 19 (10-12) ◽  
pp. 691-702 ◽  
Author(s):  
Fabian Runkel ◽  
Isabelle Aubin ◽  
Dominique Simon-Chazottes ◽  
Heinrich Büssow ◽  
Reinhard Stingl ◽  
...  
Keyword(s):  
Male Infertility ◽  
Chromosome 9 ◽  
Mutant Mice ◽  
Distal Chromosome
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