scholarly journals Reemergence of Adenovirus Type 4 Acute Respiratory Disease in Military Trainees: Report of an Outbreak during a Lapse in Vaccination

1999 ◽  
Vol 179 (6) ◽  
pp. 1531-1533 ◽  
Author(s):  
Evelyn M. Barraza ◽  
Sharon L. Ludwig ◽  
Joel C. Gaydos ◽  
John F. Brundage
Keyword(s):  
Respiratory Disease ◽  
Adenovirus Type ◽  
Acute Respiratory Disease

scholarly journals Complete Genome Sequence of Human Adenovirus Type 55 Associated with Acute Respiratory Disease, Isolated from a Military Base in the Republic of Korea

2017 ◽  
Vol 5 (10) ◽  
Author(s):  
Se Hun Gu ◽  
Dong Hyun Song ◽  
Daesang Lee ◽  
Kyungmin Huh ◽  
Hongseok Yoo ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Acute Respiratory Disease ◽  
Military Recruit ◽  
Next Generation Sequencing Technology ◽  
The Republic

ABSTRACT Human adenovirus (HAdV) (genus Mastadenovirus; family Adenoviridae) serotype 55 is a reemerging pathogen associated with acute respiratory disease. Here, we report the complete genome sequence of HAdV-55 strain AFMC 16-0011, isolated from a military recruit, using next-generation sequencing technology.

scholarly journals Household Transmission of Human Adenovirus Type 55 in Case of Fatal Acute Respiratory Disease

2019 ◽  
Vol 25 (9) ◽  
pp. 1756-1758 ◽  
Author(s):  
Shuping Jing ◽  
Jing Zhang ◽  
Mengchan Cao ◽  
Minhong Liu ◽  
Yuqian Yan ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Acute Respiratory Disease ◽  
Household Transmission

scholarly journals Genome Sequence of Human Adenovirus Type 55, a Re-Emergent Acute Respiratory Disease Pathogen in China

2012 ◽  
Vol 86 (22) ◽  
pp. 12441-12442 ◽  
Author(s):  
Q. Zhang ◽  
D. Seto ◽  
B. Cao ◽  
S. Zhao ◽  
C. Wan
Keyword(s):  
Respiratory Disease ◽  
Genome Sequence ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Acute Respiratory Disease

scholarly journals Outbreak of Acute Respiratory Disease in China Caused by B2 Species of Adenovirus Type 11

2008 ◽  
Vol 47 (3) ◽  
pp. 697-703 ◽  
Author(s):  
Z. Zhu ◽  
Y. Zhang ◽  
S. Xu ◽  
P. Yu ◽  
X. Tian ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Adenovirus Type ◽  
Acute Respiratory Disease

scholarly journals A Single-Cycle Adenovirus Type 7 Vaccine for Prevention of Acute Respiratory Disease

Viruses ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 413
Author(s):  
Brianna L. Bullard ◽  
Brigette N. Corder ◽  
Eric A. Weaver
Keyword(s):  
Respiratory Disease ◽  
A549 Cells ◽  
Adenovirus Type ◽  
Wild Type Virus ◽  
Structural Protein ◽  
Acute Respiratory Disease ◽  
Single Cycle ◽  
Replication Competent Virus ◽  
Military Recruits

Adenovirus type 7 (Ad7) infection is associated with acute respiratory disease (ARD), especially in military recruits living in close quarters. Recently, several outbreaks of Ad7 infections have occurred in civilian populations, with some cases leading to death. However, the current Ad7 vaccine is licensed for use only in military recruits because it utilizes an orally delivered wild type virus which is shed in the stool for 28 days after immunization. This poses a safety risk due to the possibility of virus spread to vulnerable populations. To address the need for a safer Ad7 vaccine for use in civilian populations, we developed a single-cycle Ad7 virus (scAd7). This scAd7 virus is deleted for the Ad7 fiber protein, so that viruses produced outside of complementing cells lines lack this essential structural protein and have severely reduced infectivity. In vitro studies in noncomplementing A549 cells showed that the scAd7 virus has genomic DNA replication kinetics and Ad7 hexon expression similar to a replication-competent virus; however, virus progeny produced after infection has impaired infectivity. Therefore, this scAd7 virus combines the safety advantages of a replication-defective virus with the increased Ad7 gene expression of a replication-competent virus. Due to these advantages, we believe that scAd7 viruses should be further studied as an alternative, safer Adenovirus 7 vaccine.

scholarly journals A Survey of Recent Adenoviral Respiratory Pathogens in Hong Kong Reveals Emergent and Recombinant Human Adenovirus Type 4 (HAdV-E4) Circulating in Civilian Populations

Viruses ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 129 ◽  
Author(s):  
Jing Zhang ◽  
June Kang ◽  
Shoaleh Dehghan ◽  
Siddharth Sridhar ◽  
Susanna Lau ◽  
...  
Keyword(s):  
Hong Kong ◽  
Respiratory Disease ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Host Adaptation ◽  
Recent Survey ◽  
Respiratory Pathogen ◽  
Respiratory Pathogens ◽  
Acute Respiratory Disease ◽  
Military Populations

Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these “old” HAdV-E4 is the absence of a critical replication motif, NF-I, which is found in all HAdV respiratory pathogens and most HAdVs. However, our recent survey of flu-like disease in children in Hong Kong reveals that the emergent HAdV-E4 pathogens circulating in civilian populations contain NF-I, indicating recombination and reflecting host-adaptation that enables the “new” HAdV-E4 to replicate more efficiently in human cells and foretells more potential HAdV-E4 outbreaks in immune-naïve civilian populations. Special attention should be paid by clinicians to this emergent and recombinant HAdV-E4 circulating in civilian populations.

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