scholarly journals Comparison between a Whole Blood Interferon‐γ Release Assay and Tuberculin Skin Testing for the Detection of Tuberculosis Infection among Patients at Risk for Tuberculosis Exposure

1999 ◽  
Vol 179 (5) ◽  
pp. 1297-1300 ◽  
Author(s):  
Moriyo Kimura ◽  
Paul J. Converse ◽  
Jacqueline Astemborski ◽  
James S. Rothel ◽  
David Vlahov ◽  
...  
Keyword(s):  
At Risk ◽  
Whole Blood ◽  
Skin Testing ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Tuberculin Skin Testing ◽  
Patients At Risk ◽  
Release Assay

Comparison of a whole blood interferon-γ assay with tuberculin skin testing for the detection of tuberculosis infection in hospitalized children in rural India

2007 ◽  
Vol 54 (3) ◽  
pp. 267-276 ◽  
Author(s):  
Sandeep Dogra ◽  
Pratibha Narang ◽  
Deepak K. Mendiratta ◽  
Pushpa Chaturvedi ◽  
Arthur L. Reingold ◽  
...  
Keyword(s):  
Whole Blood ◽  
Skin Testing ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Rural India ◽  
Tuberculin Skin Testing ◽  
Hospitalized Children

scholarly journals Comparison of an Interferon-γ Release Assay with Tuberculin Skin Testing in HIV-infected Individuals

2007 ◽  
Vol 175 (7) ◽  
pp. 737-742 ◽  
Author(s):  
Annie F. Luetkemeyer ◽  
Edwin D. Charlebois ◽  
Laura L. Flores ◽  
David R. Bangsberg ◽  
Steven G. Deeks ◽  
...  
Keyword(s):  
Skin Testing ◽  
Interferon Γ ◽  
Tuberculin Skin Testing ◽  
Release Assay

scholarly journals Diagnosis and Risk Factors of Latent Tuberculosis Infection among Healthcare Workers Using Whole Blood Human Interferon-gamma Release Assay and Tuberculin Skin Testing

2020 ◽  
pp. 15-21
Author(s):  
A. N. Umo ◽  
O. J. Akinjogunla ◽  
N. O. Umoh ◽  
G. E. Uzono
Keyword(s):  
Risk Factors ◽  
Interferon Gamma ◽  
Whole Blood ◽  
Healthcare Workers ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Interferon Gamma Release Assay ◽  
Tuberculin Skin Testing ◽  
Release Assay

This study established the diagnosis and risk factors of latent tuberculosis infection (LTBI) among health-care workers in an endemic population using Tuberculin skin test (TST) and Quantiferon TB-gold. A total of 609 Healthcare workers from tuberculosis treatment facilities in Akwa Ibom State, Nigeria were studied. The Interferon-gamma release assay was performed using 3ml of whole blood by ELISA according to the manufacturer’s instruction (Cellestis Ltd., Carnegie, Australia) after which 0.1 ml of 5 tuberculin units of Purified Protein Derivative (PPD) was administered intra-dermally to each subject. TST results were read after 72 hours by measuring the size of indurations in millimetres. Data were analysed using SPSS version 17 (SPSS Inc., Chicago, Illinois). At the threshold of 10 mm, the prevalence of LTBI by TST was 45.8% and 24.8% at the IGRA diagnostic value of ≥ 0.351 IU. Laboratory staff and ward orderlies as well as being in service for >10 years, were more significantly associated with LTBI. A moderate agreement of 76.7%, k = 0.51 was obtained between TST at 10 mm, and QFT. Neither previous exposure to TST nor BCG vaccination affected the prevalence of LTBI in the study population. The difference of 54% prevalence of LTBI between TST and QFT may be due to non-tuberculous mycobacterium (NTM) since TST is non-specific. This may have grave implications of drug toxicity and development of resistance to anti-TB drug among individuals harbouring NTM, but receiving anti-TB medication. The 76.7% agreement between the two tests is an indication that the 10 mm cut-off induration for TST is still relevant in the diagnosis of LTBI.

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