scholarly journals Familial Posterior Fossa Brain Tumors of Infancy Secondary to Germline Mutation of the hSNF5 Gene

2000 ◽  
Vol 66 (4) ◽  
pp. 1403-1406 ◽  
Author(s):  
Michael D. Taylor ◽  
Nalan Gokgoz ◽  
Irene L. Andrulis ◽  
Todd G. Mainprize ◽  
James M. Drake ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Posterior Fossa ◽  
Germline Mutation

Primary Pediatric Brain Tumors of the Posterior Fossa: Part I

2017 ◽  
pp. 301-326
Author(s):  
Kathleen Felton ◽  
Amanda Hogg ◽  
Lisa Liang ◽  
Christopher Aiken ◽  
Thomas Klonisch ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Posterior Fossa ◽  
Pediatric Brain Tumors ◽  
Pediatric Brain

scholarly journals P14.50 Clinicopathological spectrum of intracranial germ cell tumors: an Indian tertiary cancer center experience

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii78-iii78
Author(s):  
A Sahay ◽  
G Chinnaswamy ◽  
V Bhat ◽  
V Patil ◽  
T Gupta ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Germ Cell ◽  
Tumor Markers ◽  
Posterior Fossa ◽  
Germ Cell Tumors ◽  
Clinicopathological Features ◽  
Spinal Tumors ◽  
Equal Distribution ◽  
Pineal Tumors ◽  
Intracranial Germ Cell Tumors

Abstract BACKGROUND Incidence of intracranial germ cell tumors (ICGCT) in Western literature is low (0.3–0.6 %) as compared to East Asia (3–4 %), & their clinicopathological features are well documented. However, there are scant studies on ICGCT from India. MATERIAL AND METHODS Retrospective observational study of all ICGCT histologically diagnosed in our hospital from 2007–2018. Metastasis were excluded. Clinicopathological features were retrieved from hospital’s electronic medical records. RESULTS We diagnosed 82 primary ICGCT, forming approx. 0.54 % of all primary brain tumors, & 3.5% of pediatric brain tumors. Age range: 2 months-32 yrs (Median age 14 yrs). M:F ratio: 1.82:1 (53M,29F). Nearly 80% patients were pediatric (<18 yrs), & 8 very young (<3 yrs, 7M1F). Majority were suprasellar & pineal (31/82, 37% each), with one bifocal presentation. Other rarer sites: posterior fossa (4), midbrain (1), corpus callosum (1) & 11 non midline (4 thalamic, 4 frontal, 2 cerebellar, 1 CP angle). Predominant histology was germinoma (G) (51/82, 62%), while non germinomatous (NGGCT) were 31/82 (38%), of which 9 were mixed. Pure teratoma were 11 (9 immature (IT), 2 mature), & 5 pure yolk sac tumor (YST). Interestingly, all very young age group patients (<3 yrs), showed only NGGCT histology (5/8 IT, 3/8 pure YST). In contrast, G histology formed nearly 70% of all patients >3 yrs. Females were associated mainly with G (21/29, 72%). NGGCT were predominantly seen in males (M:F=2.9:1). Also, pure IT (9) were seen only in males. Posterior fossa tumors were all IT (4/4). Spinal tumors were NGGCT (1 mature teratoma, 1 YST). Majority of suprasellar tumors (25/31, 80.6%), other midline locations like corpus callosal, midbrain, & all thalamic tumors were G. However, pineal tumors showed equal distribution of G (15/31) & NGGCT (16/31). Spine screening was positive in 8 patients (6 G, 2 IT)- 7 on MRI and 1 only on CSF cytology. Serum tumor markers were raised in 13/54 cases- 6/34G(17.6%), vs 7/20 NGGCT (35%). CSF tumor markers were raised in 14/34-10/23 G (43.4%), vs 4/11 NGGCT (36.3%). Follow up was available for 37 patients (Duration 3 months-10 yrs, median 2 yrs). On f/u 6/15 (40%) NGGCT showed progression/death, while only 2/32 G relapsed (6.5%). Four deaths in G group were not directly attributable to the tumor. CONCLUSION Frequency of ICGCT in our hospital similar to western data rather than Asian, albeit with less striking male preponderance. ICGCT were tumors of 2nd decade & majority occurred in pineal/suprasellar areas. About 2/3rd were pure G on histology, and showed good prognosis. NGGCT were common in infants, males and in posterior fossa. IT were seen exclusively in males and pure YST mainly in males. Although majority of ICGCT are in midline, rarely non midline involvement also occurs, and it’s essential to exclude metastasis before considering primary ICGCT. Expectedly, NGGCT showed poorer prognosis, compared to pure germinomas.

scholarly journals The role of the basal cisterns in the development of posterior fossa skull base meningiomas

2016 ◽  
Vol 30 (3) ◽  
pp. 321-329
Author(s):  
Ioan Stefan Florian ◽  
Gheorghe Ungureanu ◽  
Alexandru Florian
Keyword(s):  
Brain Tumors ◽  
Skull Base ◽  
Posterior Fossa ◽  
Present Report ◽  
Intimate Relation ◽  
Vascular Structures ◽  
Skull Base Meningiomas ◽  
Basal Cisterns

Abstract Meningiomas account for more than 30% of all intracranial brain tumors, with 25% of them originating somewhere along the skull base and about 20% of these located in the posterior fossa. The intimate relation of these tumors with neural and vascular structures make them difficult to treat, both surgically and nonsurgically. Their treatment is further hampered by the lack of definitive recommendations, which is partially due to the fact that there is no general accepted model of classification. The present report proposes a new concept of classification of posterior fossa skull base meningiomas, one that takes into account the intimate relation of these tumors with arachnoid structures, simplifies the overcrowded landscape of their systematization and can be extended to oher skull base locations.

scholarly journals CASP9 germline mutation in a family with multiple brain tumors

2017 ◽  
Vol 28 (1) ◽  
pp. 94-102 ◽  
Author(s):  
Michael W. Ronellenfitsch ◽  
Ji-Eun Oh ◽  
Kaishi Satomi ◽  
Koichiro Sumi ◽  
Patrick N. Harter ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Germline Mutation ◽  
Multiple Brain Tumors

scholarly journals Differential diagnosis of posterior fossa brain tumors

Medicine ◽  
2017 ◽  
Vol 96 (33) ◽  
pp. e7767 ◽  
Author(s):  
Moritaka Yamauchi ◽  
Tomohisa Okada ◽  
Tsutomu Okada ◽  
Akira Yamamoto ◽  
Yasutaka Fushimi ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Brain Tumors ◽  
Posterior Fossa

scholarly journals Neural Underpinnings of Working Memory in Adult Survivors of Childhood Brain Tumors

2015 ◽  
Vol 21 (7) ◽  
pp. 494-505 ◽  
Author(s):  
Tricia Z. King ◽  
Sabrina Na ◽  
Hui Mao
Keyword(s):  
Working Memory ◽  
Brain Tumors ◽  
Posterior Fossa ◽  
Parietal Lobe ◽  
Digit Span ◽  
Memory Performance ◽  
Adult Survivors ◽  
Vigilance Task ◽  
Bold Response ◽  
Childhood Brain Tumors

AbstractAdult survivors of childhood brain tumors are at risk for cognitive performance deficits that require the core cognitive skill of working memory. Our goal was to examine the neural mechanisms underlying working memory performance in survivors. We studied the working memory of adult survivors of pediatric posterior fossa brain tumors using a letter n-back paradigm with varying cognitive workload (0-, 1-, 2-, and 3-back) and functional magnetic resonance imaging as well as neuropsychological measures. Survivors of childhood brain tumors evidenced lower working memory performance than demographically matched healthy controls. Whole-brain analyses revealed significantly greater blood-oxygen level dependent (BOLD) activation in the left superior / middle frontal gyri and left parietal lobe during working memory (2-back versus 0-back contrast) in survivors. Left frontal BOLD response negatively correlated with 2- and 3-back working memory performance, Auditory Consonant Trigrams (ACT), and Digit Span Backwards. In contrast, parietal lobe BOLD response negatively correlated with 0-back (vigilance task) and ACT. The results revealed that adult survivors of childhood posterior fossa brain tumors recruited additional cognitive control resources in the prefrontal lobe during increased working memory demands. This increased prefrontal activation is associated with lower working memory performance and is consistent with the allocation of latent resources theory. (JINS, 2015, 21, 494–505)

Prone Positioning for Posterior Fossa Tumor Resection

2013 ◽  
Author(s):  
Matthias W König ◽  
Mohamed A Mahmoud ◽  
John J McAuliffe
Keyword(s):  
Brain Tumors ◽  
Prone Position ◽  
Posterior Fossa ◽  
Tumor Resection ◽  
Posterior Fossa Tumor ◽  
Physiological Changes ◽  
Prone Positioning ◽  
Posterior Fossa Tumors ◽  
Common Malignancy

Brain tumors are the second most common malignancy in children. About one third occur in toddlers under the age of 3, and about two thirds are located in the posterior fossa. Resection of posterior fossa tumors is often a lengthy procedure that is commonly performed in the prone position. The prone position is associated with physiological changes and predisposes the patient to certain types of injuries.

scholarly journals Tumeurs Cerebrales de l'enfant en milieu Canadien-Francais

1979 ◽  
Vol 6 (3) ◽  
pp. 329-335 ◽  
Author(s):  
F. Renevey ◽  
Y. Amyot ◽  
G. Geoffroy ◽  
M. Vanasse
Keyword(s):  
Brain Tumors ◽  
Brain Stem ◽  
Posterior Fossa ◽  
Clinical Investigation ◽  
Clinical Manifestations ◽  
Tumeurs Cérébrales ◽  
Brain Stem Lesions ◽  
Stem Lesions ◽  
Invasive Techniques ◽  
Intra Cranial Pressure

SUMMARY:Between 1964 and 1976, we have seen 197 cases of cerebral tumors in children. We have studied the frequency of each histological group of tumors, their localization, the results of the clinical investigation, their clinical manifestations and the prognosis for each group.This study has confirmed that in children brain tumors are more frequently localized in the posterior fossa (56.4%). As in other series, tumors derived from the glia represent nearly 80% of the total. Clinically, increased intra-cranial pressure is the most frequent manifestation of posterior fossa lesion (75% of cases) while cerebellar involvement was seen in 60% of these childdren. Brain stem lesions and supratentorial tumors are more insidious in their presentation and their clinical manifestations more diversified.The EEG appeared useful in the investigation of brain tumors and showed irregularities in 78% of our patients. However, a more specific diagnosis required more invasive techniques such as angiography, pneumoencephalography or ventriculography.As in previous series, the mortality rate remained high in the children we have followed, particularly for some groups of tumors (glioblastoma, medulloblastoma, brain stem lesions). It is to be hoped that with the introduction of the CT Scan, the improvement of neurosurgical techniques and the use of immuno and chemotherapy, the prognosis may be improved.

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