scholarly journals A 28-kb Deletion Spanning D15S63 (PW71) in Five Families: A Rare Neutral Variant?

1999 ◽  
Vol 65 (6) ◽  
pp. 1588-1594 ◽  
Author(s):  
Karin Buiting ◽  
Bärbel Dittrich ◽  
Bernd Dworniczak ◽  
Israela Lerer ◽  
Dvorah Abeliovich ◽  
...  
Keyword(s):  
Neutral Variant

Factors driving lexical variation in L2 French: A variationist study of automobile, auto, voiture, char and machine

2008 ◽  
Vol 18 (3) ◽  
pp. 365-381 ◽  
Author(s):  
TERRY NADASDI ◽  
RAYMOND MOUGEON ◽  
KATHERINE REHNER
Keyword(s):  
Second Language ◽  
Language Learners ◽  
Second Language Learners ◽  
Native Speakers ◽  
Native Speaker ◽  
External Factors ◽  
Home Language ◽  
Lexical Variation ◽  
Neutral Variant ◽  
The Prestige

ABSTRACTOur paper examines lexical variation in the spoken French of second language learners and focuses on words referring to the notion of ‘automobile’ (i.e., automobile, auto, voiture, char and machine). Results reveal that while students do follow the native speaker pattern of using the neutral variant auto in most instances, they diverge from native speakers by making no use of the vernacular form char and relatively high use of the prestige variant voiture. The principal external factors that influence variant choice are students' home language and the representation of variants in the input to which students are exposed.

A neutral variant involved in a complex CFTR allele contributes to a severe cystic fibrosis phenotype

2005 ◽  
Vol 116 (6) ◽  
pp. 454-460 ◽  
Author(s):  
J�r�me Clain ◽  
Jacqueline Lehmann-Che ◽  
Emmanuelle Girodon ◽  
Joanna Lipecka ◽  
Aleksander Edelman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Neutral Variant

scholarly journals Evidence for classification of c.1852_1853AA>GC in MLH1 as a neutral variant for Lynch syndrome

2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Adela Castillejo ◽  
Carla Guarinos ◽  
Ana Martinez-Canto ◽  
Victor-Manuel Barbera ◽  
Cecilia Egoavil ◽  
...  
Keyword(s):  
Lynch Syndrome ◽  
Neutral Variant

Hb YAOUNDÉ [β134(H12)Val →Ala], A NEW NEUTRAL VARIANT FOUND IN ASSOCIATION WITH Hb KENITRA [β69(E13)Gly →Arg] IN A PATIENT FROM CAMEROON

Hemoglobin ◽  
2001 ◽  
Vol 25 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Angoué P. Yapo ◽  
Danielle Promé ◽  
Catherine Claparols ◽  
Jean Riou ◽  
Frédéric Galactéros ◽  
...  
Keyword(s):  
Neutral Variant

scholarly journals Neutral quasispecies evolution and the maximal entropy random walk

2021 ◽  
Vol 7 (16) ◽  
pp. eabb2376
Author(s):  
M. Smerlak
Keyword(s):  
Random Walk ◽  
Evolutionary Dynamics ◽  
Maximal Entropy ◽  
Eigenvector Centrality ◽  
Mutational Robustness ◽  
Neutral Variant ◽  
Word Game ◽  
Selection For ◽  
Neutral Mutations ◽  
Quasispecies Evolution

Even if they have no impact on phenotype, neutral mutations are not equivalent in the eyes of evolution: A robust neutral variant—one which remains functional after further mutations—is more likely to spread in a large, diverse population than a fragile one. Quasispecies theory shows that the equilibrium frequency of a genotype is proportional to its eigenvector centrality in the neutral network. This paper explores the link between the selection for mutational robustness and the navigability of neutral networks. I show that sequences of neutral mutations follow a “maximal entropy random walk,” a canonical Markov chain on graphs with nonlocal, nondiffusive dynamics. I revisit M. Smith’s word-game model of evolution in this light, finding that the likelihood of certain sequences of substitutions can decrease with the population size. These counterintuitive results underscore the fertility of the interface between evolutionary dynamics, information theory, and physics.

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