scholarly journals STAT5 Signaling in Sexually Dimorphic Gene Expression and Growth Patterns

1999 ◽  
Vol 65 (4) ◽  
pp. 959-965 ◽  
Author(s):  
Helen W. Davey ◽  
Richard J. Wilkins ◽  
David J. Waxman
Keyword(s):  
Gene Expression ◽  
Growth Patterns ◽  
Sexually Dimorphic ◽  
Dimorphic Gene Expression

scholarly journals Sexually dimorphic gene expression and transcriptome evolution provide mixed evidence for a fast-Z effect in Heliconius

2019 ◽  
Vol 32 (3) ◽  
pp. 194-204 ◽  
Author(s):  
Ana Pinharanda ◽  
Marjolaine Rousselle ◽  
Simon H. Martin ◽  
Joe J. Hanly ◽  
John W. Davey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sexually Dimorphic ◽  
Dimorphic Gene Expression

scholarly journals Sexually dimorphic gene expression in the chick brain before gonadal differentiation

2009 ◽  
Vol 88 (5) ◽  
pp. 1003-1015 ◽  
Author(s):  
S.I. Lee ◽  
W.K. Lee ◽  
J.H. Shin ◽  
B.K. Han ◽  
S. Moon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sexually Dimorphic ◽  
Gonadal Differentiation ◽  
Chick Brain ◽  
Dimorphic Gene Expression

scholarly journals Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster

BMC Genomics ◽  
2007 ◽  
Vol 8 (1) ◽  
pp. 454 ◽  
Author(s):  
Dean A Baker ◽  
Lisa A Meadows ◽  
Jing Wang ◽  
Julian AT Dow ◽  
Steven Russell
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Sexually Dimorphic ◽  
Dimorphic Gene Expression

KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts

2018 ◽  
Vol 165 (4) ◽  
pp. 335-342 ◽  
Author(s):  
Hayase Mizukami ◽  
Jun-Dal Kim ◽  
Saori Tabara ◽  
Weizhe Lu ◽  
Chulwon Kwon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sexually Dimorphic ◽  
Mouse Embryonic Fibroblasts ◽  
Embryonic Fibroblasts ◽  
Dimorphic Gene Expression

scholarly journals Mating Changes Sexually Dimorphic Gene Expression in the Seed Beetle Callosobruchus maculatus

2017 ◽  
Vol 9 (3) ◽  
pp. 677-699 ◽  
Author(s):  
Elina Immonen ◽  
Ahmed Sayadi ◽  
Helen Bayram ◽  
Göran Arnqvist
Keyword(s):  
Gene Expression ◽  
Callosobruchus Maculatus ◽  
Sexually Dimorphic ◽  
Seed Beetle ◽  
Dimorphic Gene Expression

scholarly journals Stat5b Regulates Sexually Dimorphic Gene Expression in Zebrafish Liver

2018 ◽  
Vol 9 ◽  
Author(s):  
Peipei Huang ◽  
Shuting Xiong ◽  
Jingliang Kang ◽  
Jie Mei ◽  
Jian-Fang Gui
Keyword(s):  
Gene Expression ◽  
Sexually Dimorphic ◽  
Zebrafish Liver ◽  
Dimorphic Gene Expression

Abstract P787: Sexually Dimorphic Gene Expression Molecular Correlates of Improvement in Human Ischemic Stroke

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Hajar Amini ◽  
Bodie Knepp ◽  
Heather Hull ◽  
Paulina Carmona-Mora ◽  
Marisa Hakoupian ◽  
...  
Keyword(s):  
Gene Expression ◽  
Risk Factors ◽  
Protein Synthesis ◽  
Sex Differences ◽  
Ischemic Stroke ◽  
Major Protein ◽  
Sexually Dimorphic ◽  
Stroke Outcome ◽  
Males And Females ◽  
Dimorphic Gene Expression

Objective: Ischemic stroke (IS) is sexually dimorphic for risk factors, age, heritability, causes, treatment, and outcome. We identified transcriptional correlates with 90-day outcome that differed between male and female IS subjects. Methods: RNA from 72 samples from 2 peripheral blood draws (at ≤3 and 24h post IS onset) was analyzed on Affymetrix U133 Plus 2 microarrays. These represented samples from 36 CLEAR trial IS patients treated with tPA with or without eptifibatide after the first blood sample within 3 hours of stroke onset. Changes in gene expression levels (deltaGE) between 3h and 24h were calculated and the association with percent NIH Stroke Scale (NIHSS) improvement from 3h to 90 days (% Improvement) examined. We used mixed-effects linear regression, including Treatment, Age, Sex, Vascular Risk Factors, 3h NIHSS, % Improvement, and a Sex * % Improvement interaction. Sex differences in association of gene expression with % Improvement were determined by examining the Sex * % Improvement interaction term, p<0.005 was considered statistically significant. Results: 577 genes correlated differently with % Improvement in IS males and females. These included matrix metalloproteinases (MMPs), which play a major role in BBB dysfunction and outcomes post IS. MMP11 , MMP14 and MM17 correlated with % Improvement in opposite direction in males and females. Inflammatory genes like IL-27 , implicated in infarct volume and stroke outcome, and ABC transporters ( ABCC9 ) also had opposite correlation with % Improvement in males and females. Calmodulin 1 ( CAML1 ) was also sexually dimorphic, and a SNP in CALM1 has been implicated in IS risk and blood coagulation in female IS patients. EIF2 signaling, a major protein synthesis pathway was activated in males (adj. p = 1e-8), while suppressed in females (adj. p value = 1e-9). Protein synthesis and associated unfolded protein response cascade have previously been implicated in stroke outcome. Conclusions: The identified sexually dimorphic gene expression associated with 90-day improvement might relate to sex differences in blood immune and clotting pathways. The findings expand our understanding of the genomic underpinnings associated with stroke outcome and may serve as potential sex-specific treatment targets.

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