scholarly journals Assessing the Feasibility of Linkage Disequilibrium Methods for Mapping Complex Traits: An Initial Screen for Bipolar Disorder Loci on Chromosome 18

1999 ◽  
Vol 64 (6) ◽  
pp. 1670-1678 ◽  
Author(s):  
Michael A. Escamilla ◽  
L. Alison McInnes ◽  
Mitzi Spesny ◽  
Victor I. Reus ◽  
Susan K. Service ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Linkage Disequilibrium ◽  
Complex Traits ◽  
Chromosome 18 ◽  
Mapping Complex Traits

scholarly journals Joint Linkage and Linkage Disequilibrium Mapping in Natural Populations

Genetics ◽  
2001 ◽  
Vol 157 (2) ◽  
pp. 899-909
Author(s):  
Rongling Wu ◽  
Zhao-Bang Zeng
Keyword(s):  
Linkage Disequilibrium ◽  
Complex Traits ◽  
Positional Cloning ◽  
Genome Structure ◽  
Natural Populations ◽  
Linkage Disequilibrium Mapping ◽  
Linkage Disequilibria ◽  
Time Simulation ◽  
New Strategy ◽  
Fisher Scoring Algorithm

Abstract A new strategy for studying the genome structure and organization of natural populations is proposed on the basis of a combined analysis of linkage and linkage disequilibrium using known polymorphic markers. This strategy exploits a random sample drawn from a panmictic natural population and the open-pollinated progeny of the sample. It is established on the principle of gene transmission from the parental to progeny generation during which the linkage between different markers is broken down due to meiotic recombination. The strategy has power to simultaneously capture the information about the linkage of the markers (as measured by recombination fraction) and the degree of their linkage disequilibrium created at a historic time. Simulation studies indicate that the statistical method implemented by the Fisher-scoring algorithm can provide accurate and precise estimates for the allele frequencies, recombination fractions, and linkage disequilibria between different markers. The strategy has great implications for constructing a dense linkage disequilibrium map that can facilitate the identification and positional cloning of the genes underlying both simple and complex traits.

Comprehensive evaluation of mapping complex traits in wheat using genome-wide association studies

2021 ◽  
Vol 42 (1) ◽  
Author(s):  
Dinesh K. Saini ◽  
Yuvraj Chopra ◽  
Jagmohan Singh ◽  
Karansher S. Sandhu ◽  
Anand Kumar ◽  
...  
Keyword(s):  
Complex Traits ◽  
Comprehensive Evaluation ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Mapping Complex Traits

Linkage analysis between pericentrometric markers on chromosome 18 and bipolar disorder: A replication test

1995 ◽  
Vol 59 (1-2) ◽  
pp. 7-15 ◽  
Author(s):  
Wolfgang Maier ◽  
Joachim Hallmayer ◽  
Peter Zill ◽  
Brigitta Bondy ◽  
Dirk Lichtermann ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Linkage Analysis ◽  
Chromosome 18

Whole-genome linkage disequilibrium screening for complex traits in horses

2007 ◽  
Vol 277 (6) ◽  
pp. 663-672 ◽  
Author(s):  
Teruaki Tozaki ◽  
Kei-ichi Hirota ◽  
Telhisa Hasegawa ◽  
Nobushige Ishida ◽  
Takashi Tobe
Keyword(s):  
Linkage Disequilibrium ◽  
Complex Traits ◽  
Whole Genome
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