scholarly journals Founder Effect at PGL1 in Hereditary Head and Neck Paraganglioma Families from The Netherlands

1998 ◽  
Vol 63 (2) ◽  
pp. 468-473 ◽  
Author(s):  
Evert M. van Schothorst ◽  
Jeroen C. Jansen ◽  
Edward Grooters ◽  
Duncan E.M. Prins ◽  
Joris J. Wiersinga ◽  
...  
Keyword(s):  
The Netherlands ◽  
Head And Neck ◽  
Founder Effect ◽  
Head And Neck Paraganglioma

Is the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD ) gene due to a founder effect in Chinese head and neck paraganglioma patients?

2011 ◽  
Vol 121 (8) ◽  
pp. 1760-1764 ◽  
Author(s):  
Yang Zha ◽  
Xing-ming Chen ◽  
Ching-wan Lam ◽  
Soo-chin Lee ◽  
Sui-fan Tong ◽  
...  
Keyword(s):  
Head And Neck ◽  
Succinate Dehydrogenase ◽  
Founder Effect ◽  
Sdhd Gene ◽  
Head And Neck Paraganglioma

Surgical Outcome of Head and Neck Paraganglioma

Skull Base ◽  
2009 ◽  
Vol 19 (03) ◽  
Author(s):  
Masoud Zarandy ◽  
Ali Meighani ◽  
M. Khorsandi ◽  
Nasrin Yazdani ◽  
Mahdi Malekpour
Keyword(s):  
Head And Neck ◽  
Surgical Outcome ◽  
Head And Neck Paraganglioma

Dynamic contrast‐enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma

Head & Neck ◽  
2021 ◽  
Author(s):  
Soumya Ranjan Malla ◽  
Ashu Seith Bhalla ◽  
Smita Manchanda ◽  
Devasenathipathy Kandasamy ◽  
Rakesh Kumar ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Head And Neck ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Head And Neck Paraganglioma

Novel germline SDHD deletion associated with an unusual sympathetic head and neck paraganglioma

Head & Neck ◽  
2010 ◽  
Vol 33 (8) ◽  
pp. 1233-1240 ◽  
Author(s):  
Juan Cadiñanos ◽  
José L. Llorente ◽  
Jorge de la Rosa ◽  
José A. Villameytide ◽  
Rafael Illán ◽  
...  
Keyword(s):  
Head And Neck ◽  
Head And Neck Paraganglioma

Quantitative biomarkers allow the diagnosis of head and neck paraganglioma on multiparametric MRI

2021 ◽  
pp. 109911
Author(s):  
Emina Arsovic ◽  
Marion Montava ◽  
Nicolas Fakhry ◽  
Jean-Pierre Lavieille ◽  
Karel Pacak ◽  
...  
Keyword(s):  
Head And Neck ◽  
Multiparametric Mri ◽  
Head And Neck Paraganglioma

Update and external validation of a multivariable prediction model for tube feeding dependency for at least four weeks during chemoradiotherapy for head and neck cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 6040-6040
Author(s):  
Anna C. H. Willemsen ◽  
Annemieke Kok ◽  
Laura W.J. Baijens ◽  
J. P. De Boer ◽  
Remco de Bree ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Radiation Dose ◽  
The Netherlands ◽  
Prediction Model ◽  
Head And Neck ◽  
Neck Cancer ◽  
Predictive Value ◽  
Medical Center ◽  
External Validation ◽  
Tube Feeding

6040 Background: Patients who receive chemoradiation or bioradiation (CRT/BRT) for locally advanced head and neck squamous cell carcinoma (LAHNSCC) often experience high toxicity rates, which may interfere with oral intake, leading to (temporary) tube feeding (TF) dependency. International guidelines recommend gastrostomy insertion when the expected use of TF exceeds four weeks. In this study we aimed to update and externally validate a prediction model to identify patients in need for TF for at least four weeks, meeting the international criteria for prophylactic gastrostomy insertion. Methods: This retrospective multicenter cohort study was performed in four tertiary referral head and neck cancer centers in the Netherlands. The prediction model was developed using data from the University Medical Center Utrecht and the Netherlands Cancer Institute. The model was externally validated in patients from the Maastricht University Medical Center and Radboud University Medical Center. The primary endpoint was TF, initiated during or within 30 days after completion of CRT/BRT, and administered for at least four weeks. Potential predictors were retrieved from patient medical records and radiotherapy dose-volume parameters were calculated. Results: The developmental and validation cohort included 409 and 334 patients respectively. Multivariable analysis showed significant predictive value (p < 0.05) for adjusted diet at start of CRT/BRT, percentage weight change prior to treatment initiation, WHO performance status, tumor-site, nodal stage, mean radiation dose to the contralateral parotid gland, and mean radiation dose to the oral cavity. The area under the receiver operating characteristics curve for the updated model was 0.73 and after external validation 0.64. Positive and negative predictive value at 90% cut off were 80.0% and 48.2% respectively. Conclusions: This externally validated prediction model to estimate TF-dependency for at least four weeks in LAHNSCC patients performs well. This model, which will be presented, can be used in clinical practice to guide personalized decision making on prophylactic gastrostomy insertion.

The spectrum of SDHD mutations in Russian patients with head and neck paraganglioma

2018 ◽  
Vol 128 (12) ◽  
pp. 1174-1179
Author(s):  
Marina V. Shulskaya ◽  
Maria I. Shadrina ◽  
Natalia A. Bakilina ◽  
Svetlana V. Zolotova ◽  
Petr A. Slominsky
Keyword(s):  
Head And Neck ◽  
Head And Neck Paraganglioma
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