scholarly journals Genetic Association of Apolipoprotein E with Age-Related Macular Degeneration

1998 ◽  
Vol 63 (1) ◽  
pp. 200-206 ◽  
Author(s):  
Caroline C.W. Klaver ◽  
Mike Kliffen ◽  
Cornelia M. van Duijn ◽  
Albert Hofman ◽  
Marc Cruts ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Macular Degeneration ◽  
Genetic Association ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 635
Author(s):  
Monica L. Hu ◽  
Joel Quinn ◽  
Kanmin Xue
Keyword(s):  
Risk Factor ◽  
Apolipoprotein E ◽  
Macular Degeneration ◽  
Amyloid Beta ◽  
Complement System ◽  
Genetic Risk ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Retinal Inflammation ◽  
The Complement System

Age-related macular degeneration (AMD) is a multifactorial retinal disorder that is a major global cause of severe visual impairment. The development of an effective therapy to treat geographic atrophy, the predominant form of AMD, remains elusive due to the incomplete understanding of its pathogenesis. Central to AMD diagnosis and pathology are the hallmark lipid and proteinaceous deposits, drusen and reticular pseudodrusen, that accumulate in the subretinal pigment epithelium and subretinal spaces, respectively. Age-related changes and environmental stressors, such as smoking and a high-fat diet, are believed to interact with the many genetic risk variants that have been identified in several major biochemical pathways, including lipoprotein metabolism and the complement system. The APOE gene, encoding apolipoprotein E (APOE), is a major genetic risk factor for AMD, with the APOE2 allele conferring increased risk and APOE4 conferring reduced risk, in comparison to the wildtype APOE3. Paradoxically, APOE4 is the main genetic risk factor in Alzheimer's disease, a disease with features of neuroinflammation and amyloid-beta deposition in common with AMD. The potential interactions of APOE with the complement system and amyloid-beta are discussed here to shed light on their roles in AMD pathogenesis, including in drusen biogenesis, immune cell activation and recruitment, and retinal inflammation.

The role of apolipoprotein E (rs7412 and rs429358) in age-related macular degeneration

2018 ◽  
Vol 39 (4) ◽  
pp. 457-462 ◽  
Author(s):  
Rasa Liutkeviciene ◽  
Alvita Vilkeviciute ◽  
Alina Smalinskiene ◽  
Abdonas Tamosiunas ◽  
Janina Petkeviciene ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related

Apolipoprotein E genotype and risk for development of cataract and age-related macular degeneration

2008 ◽  
Vol 86 (4) ◽  
pp. 401-403 ◽  
Author(s):  
Øygunn A. Utheim ◽  
Jon Ståle Ritland ◽  
Tor P. Utheim ◽  
Thomas Espeseth ◽  
Stian Lydersen ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Apolipoprotein E Genotype

Genetic association of VEGF and PEDF polymorphisms with age-related macular degeneration in Korean

2013 ◽  
Vol 35 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Hyun-Seok Kim ◽  
Yeong Hoon Kim ◽  
Jee Won Mok ◽  
Choun-Ki Joo
Keyword(s):  
Macular Degeneration ◽  
Genetic Association ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Association between Apolipoprotein E Polymorphisms and Age-related Macular Degeneration: A HuGE Review and Meta-Analysis

2006 ◽  
Vol 164 (9) ◽  
pp. 813-822 ◽  
Author(s):  
Ammarin Thakkinstian ◽  
Steve Bowe ◽  
Mark McEvoy ◽  
Wayne Smith ◽  
John Attia
Keyword(s):  
Apolipoprotein E ◽  
Macular Degeneration ◽  
Meta Analysis ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration

2015 ◽  
Vol 7 (2) ◽  
pp. 211-226 ◽  
Author(s):  
Olivier Levy ◽  
Bertrand Calippe ◽  
Sophie Lavalette ◽  
Shulong J Hu ◽  
William Raoul ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Macular Degeneration ◽  
Chronic Inflammation ◽  
Mononuclear Phagocyte ◽  
Age Related Macular Degeneration ◽  
Age Related
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