scholarly journals A Breast Cancer Patient of Scottish Descent with Germ-Line Mutations in BRCA1 and BRCA2

1998 ◽  
Vol 62 (6) ◽  
pp. 1543-1544 ◽  
Author(s):  
Alexander Liede ◽  
Pauline Rehal ◽  
Danny Vesprini ◽  
Elaine Jack ◽  
John Abrahamson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Germ Line ◽  
Brca1 And Brca2 ◽  
Germ Line Mutations ◽  
Scottish Descent

A breast cancer patient from Italy with germline mutations in both the BRCA1 and BRCA2 genes

2005 ◽  
Vol 91 (2) ◽  
pp. 203-205 ◽  
Author(s):  
Antonino Musolino ◽  
Nadia Naldi ◽  
Maria Michiara ◽  
Maria A. Bella ◽  
Paola Zanelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Germline Mutations ◽  
Brca1 And Brca2 ◽  
Brca1 And Brca2 Genes

0-8. Germ-line mutations in BRCA1 and BRCA2 are seldom found in `unilateral breast cancer only' families

The Breast ◽  
1997 ◽  
Vol 6 (4) ◽  
pp. 227
Author(s):  
F. Hogervorst ◽  
M. Ligtenberg ◽  
G. Brink ◽  
S. Hageman ◽  
F. Menko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Germ Line ◽  
Brca1 And Brca2 ◽  
Unilateral Breast Cancer ◽  
Germ Line Mutations

THE RELATION OF COPPING STRATEGY BY LOOKING SOCIAL SUPPORT WITH STRESS LEVEL OF BREAST CANCER PATIENT WHO GONE TROUGH CHEMOTHERAPY

2018 ◽  
Vol 1 (1) ◽  
pp. 51-54
Author(s):  
Sri Burhani Putri
Keyword(s):  
Breast Cancer ◽  
Social Support ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Cross Sectional Study ◽  
P Value ◽  
Spiritual Support ◽  
Cross Sectional ◽  
Breast Cancer Chemotherapy ◽  
Patient Stress

Breast cancer is one of the most common illness that killed woman. One of the therapy to cure breast cancer is chemotherapy. Chemotherapy has side effect either physical and psychology, that caused people who’s in chemo therapy, prone to stress. Stress effected by many factors, such as characteristic and chopping strategy that patient has been using. The aim of this research is to get a perspective about the relation of characteristic and chopping strategy with breast cancer patient stress, whose in chemo therapy. This research using cross sectional study and taking sample by using accidental sampling method. The data analyzed by using bavariat and multivariat with variable result shows that breast cancer patient stress who has chemo therapy realted to age characteristic (p value = 0.00) the time since they diagnosed with cancer (pvalue = 0.03), how long they have chemo therapy (pvalue = 0.00) and chopping strategyby looking social support (pvalue = 0.00) looking for spiritual (pvalue = 0.00) with dominan variable which related to stress is chopping strategy to looking spiritual support (coeffecients B = -1.139).   Key words : Breast cancer, chemotherapy, stress  

scholarly journals Tumor collagen framework from bright-field histology images predicts overall survival of breast carcinoma patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mindaugas Morkunas ◽  
Dovile Zilenaite ◽  
Aida Laurinaviciene ◽  
Povilas Treigys ◽  
Arvydas Laurinavicius
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Cox Regression ◽  
Regional Lymph Node ◽  
Histological Grade ◽  
Biological Information ◽  
Lymph Node Status ◽  
Bright Field

AbstractWithin the tumor microenvironment, specifically aligned collagen has been shown to stimulate tumor progression by directing the migration of metastatic cells along its structural framework. Tumor-associated collagen signatures (TACS) have been linked to breast cancer patient outcome. Robust and affordable methods for assessing biological information contained in collagen architecture need to be developed. We have developed a novel artificial neural network (ANN) based approach for tumor collagen segmentation from bright-field histology images and have tested it on a set of tissue microarray sections from early hormone receptor-positive invasive ductal breast carcinoma stained with Sirius Red (1 core per patient, n = 92). We designed and trained ANNs on sets of differently annotated image patches to segment collagen fibers and extracted 37 features of collagen fiber morphometry, density, orientation, texture, and fractal characteristics in the entire cohort. Independent instances of ANN models trained on highly differing annotations produced reasonably concordant collagen segmentation masks and allowed reliable prognostic Cox regression models (with likelihood ratios 14.11–22.99, at p-value < 0.05) superior to conventional clinical parameters (size of the primary tumor (T), regional lymph node status (N), histological grade (G), and patient age). Additionally, we noted statistically significant differences of collagen features between tumor grade groups, and the factor analysis revealed features resembling the TACS concept. Our proposed method offers collagen framework segmentation from bright-field histology images and provides novel image-based features for better breast cancer patient prognostication.

Sign in / Sign up

Export Citation Format

Share Document