A Directed, Permanent, Genetic Change Involving the Segregation-Distortion System in Drosophila melanogaster

1962 ◽  
Vol 96 (888) ◽  
pp. 161-165 ◽  
Author(s):  
L. Sandler
Keyword(s):  
Drosophila Melanogaster ◽  
Segregation Distortion ◽  
Genetic Change

scholarly journals THE MECHANISM OF A BROODING EFFECT ASSOCIATED WITH SEGREGATION DISTORTION IN DROSOPHILA MELANOGASTER

Genetics ◽  
1973 ◽  
Vol 74 (4) ◽  
pp. 619-631
Author(s):  
D L Hartl
Keyword(s):  
Drosophila Melanogaster ◽  
Segregation Distortion ◽  
Mature Sperm ◽  
Temperature Sensitive ◽  
Short Time

ABSTRACT The recovery of the SD chromosome from a heterozygous SD male increases with brood. This is independent of the age of the female, occurs during the time the sperm are stored in the females, disappears when the segregation distortion is suppressed, and is temperature-sensitive-temperature shocks above or below 25°C applied to the mature sperm both tend to accelerate the increase in the recovery of SD. All this suggests the existence of a class of sperm affected by SD in which the sperm are able to fertilize eggs for a short time following ejaculation but become dysfunctional thereafter.

scholarly journals AGING EFFECT ON THE PHENOMENON OF SEGREGATION DISTORTION IN DROSOPHILA MELANOGASTER

Genetics ◽  
1969 ◽  
Vol 63 (1) ◽  
pp. 121-131
Author(s):  
Yuichiro Hiraizumi ◽  
Susan S Watanabe
Keyword(s):  
Drosophila Melanogaster ◽  
Segregation Distortion ◽  
Aging Effect

scholarly journals A MODIFIED MODEL OF SEGREGATION DISTORTION IN DROSOPHILA MELANOGASTER

Genetics ◽  
1980 ◽  
Vol 95 (3) ◽  
pp. 693-706
Author(s):  
Yuichiro Hiraizumi ◽  
Diana W Martin ◽  
Irene A Eckstrand
Keyword(s):  
Drosophila Melanogaster ◽  
Segregation Distortion ◽  
Necessary Condition ◽  
S Locus ◽  
Multiple Alleles ◽  
Modified Model ◽  
E Coli ◽  
Repressor Complex ◽  
S Alleles ◽  
Sperm Dysfunction

ABSTRACT Elements of the Segregation Distorter (SD) system of Drosophila melanogaster, Sd and Rsp, were analyzed and the following points were established: (1) The model of multiple alleles at the Rsp  s locus proposed by MARTIN and HIRAIZUMI (1979) is supported by our observations. (2) A modifier of SD, tentatively symbolized M(SD), was found close to cn (2R-57.5). (3) Sd heterozygous males were found to show, under certain genotypic condition, almost complete sterility.——Based upon these observations, the following modified model of segregation distortion is proposed: (1) The M(SD) locus produces a multimeric repressor protein that binds to the Rsp locus as a necessary condition for normal spermiogenesis. M(SD) homozygotes produce a repressor M(SD)/M(SD); whereas, a homozygote for its normal allele M+(SD) produces a M+(SD)/M+(SD) repressor. M(SD)/M+(SD) heterzygotes produce a M(SD)/M+(SD) repressor. (2) The Sd locus produces a certain product that, like an inducer in the lactose system of E. coli, tends to bind with the repressor complexed with the Rsp locus. This binding disrupts the repressor-Rsp complex, causing Rsp locus to be turned on. The product of Rsp transcription, in turn, results in sperm dysfunction. (3) Rsp  i, an allele of Rsp, has a strong complexing affinity with the repressor such that the Rsp  i-repressor complex is "resistant" to the inducing activity of Sd product. Rsp  s, on the other hand, has a weaker complexing affinity than that of Rsp  i, and the degree of affinity varies among different Rsp  s alleles.——A possible extension of the above model is discussed.

scholarly journals DEVIANT SEX RATIO ASSOCIATED WITH SEGREGATION DISTORTION IN DROSOPHILA MELANOGASTER

Genetics ◽  
1967 ◽  
Vol 55 (4) ◽  
pp. 681-697 ◽  
Author(s):  
Yuichiro Hiraizumi ◽  
Kyoko Nakazima
Keyword(s):  
Drosophila Melanogaster ◽  
Sex Ratio ◽  
Segregation Distortion
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