Comparative Genetics of Drosophila tripunctata Loew

1954 ◽  
Vol 88 (838) ◽  
pp. 57-61 ◽  
Author(s):  
Jack Bennett
Keyword(s):  
Comparative Genetics

scholarly journals John Hilton Edwards. 26 March 1928 — 11 October 2007

2017 ◽  
Vol 63 ◽  
pp. 215-242
Author(s):  
Malcolm A. Ferguson-Smith
Keyword(s):  
Population Genetics ◽  
Trisomy 21 ◽  
Genetic Linkage ◽  
Human Genetics ◽  
Clinical Genetics ◽  
Provisional Diagnosis ◽  
Comparative Genetics ◽  
Senior Lecturer ◽  
Practice Of Medicine ◽  
Almost All

John Edwards was a human geneticist who pioneered the development of clinical genetics in Birmingham. His name is known to all in the field for his discovery in 1960 of trisomy 18, the second trisomic condition to be described in humans after trisomy 21 in Down syndrome in 1959. He was an astute clinician and recognized that if other human chromosome aberrations were to occur, they would be associated with a similar pattern of multiple malformations and handicap. His observation of a nine-week-old child with the provisional diagnosis of Ullich–Turner syndrome suggested this possibility, which was confirmed in samples taken by Edwards at autopsy. His early interest in genetic aspects of disease is evident from his study of Peutz–Jegher syndrome published in 1957. These and similar experiences led him to a varied career in genetics, which at that time seemed to have little place in the practice of medicine. His clinical interests were complemented by his research in population genetics, statistics, genetic linkage, gene mapping and comparative genetics. He was appointed Lecturer in Social Medicine in Birmingham in 1956 and almost all of the next 23 years were spent there as Senior Lecturer, Reader and, from 1967, Professor of Human Genetics. In 1979 he moved to Oxford to become Professor of Genetics in the Biochemistry Department. He retired in 1995 and continued to work on comparative genomics in collaboration with colleagues in Australia and New Zealand. He died in 2007 and is remembered as a kind physician and an outstanding diagnostician. An exceptional scientist, he had a most original mind and a keen wit and was a critical commentator on developments in science.

scholarly journals Recombination in the Genome of Chlamydia trachomatis Involving the Polymorphic Membrane Protein C Gene Relative to ompA and Evidence for Horizontal Gene Transfer

2004 ◽  
Vol 186 (13) ◽  
pp. 4295-4306 ◽  
Author(s):  
João P. Gomes ◽  
William J. Bruno ◽  
Maria J. Borrego ◽  
Deborah Dean
Keyword(s):  
Chlamydia Trachomatis ◽  
Insertion Sequence ◽  
Tissue Specificity ◽  
Phylogenetic Analyses ◽  
High Rate ◽  
Clinical Samples ◽  
Genome Plasticity ◽  
Comparative Genetics ◽  
Phylogenetic Reconstructions ◽  
Distinct Disease

ABSTRACT Genome sequencing of Chlamydia trachomatis serovar D has identified polymorphic membrane proteins (Pmp) that are a newly recognized protein family unique to the Chlamydiaceae family. Cumulative data suggest that these diverse proteins are expressed on the cell surface and might be immunologically important. We performed phylogenetic analyses and statistical modeling with 18 reference serovars and 1 genovariant of C. trachomatis to examine the evolutionary characteristics and comparative genetics of PmpC and pmpC, the gene that encodes this protein. We also examined 12 recently isolated ocular and urogenital clinical samples, since reference serovars are laboratory adapted and may not represent strains that are presently responsible for human disease. Phylogenetic reconstructions revealed a clear distinction for disease groups, corresponding to levels of tissue specificity and virulence of the organism. Further, the most prevalent serovars, E, F, and Da, formed a distinct clade. According to the results of comparative genetic analyses, these three genital serovars contained two putative insertion sequence (IS)-like elements with 10- and 15-bp direct repeats, respectively, while all other genital serovars contained one IS-like element. Ocular trachoma serovars also contained both insertions. Previously, no IS-like elements have been identified for Chlamydiaceae. Surprisingly, 7 (58%) of 12 clinical isolates revealed pmpC sequences that were identical to the sequences of other serovars, providing clear evidence for a high rate of whole-gene recombination. Recombination and the differential presence of IS-like elements among distinct disease and prevalence groups may contribute to genome plasticity, which may lead to adaptive changes in tissue tropism and pathogenesis over the course of the organism's evolution.

scholarly journals Comparative genetics of the inv-spa invasion gene complex of Salmonella enterica.

1997 ◽  
Vol 179 (6) ◽  
pp. 1985-1991 ◽  
Author(s):  
E F Boyd ◽  
J Li ◽  
H Ochman ◽  
R K Selander
Keyword(s):  
Salmonella Enterica ◽  
Gene Complex ◽  
Comparative Genetics

scholarly journals Comparative Genetics of Seed Size Traits in Divergent Cereal Lineages Represented by Sorghum (Panicoidae) and Rice (Oryzoidae)

2015 ◽  
Vol 5 (6) ◽  
pp. 1117-1128 ◽  
Author(s):  
D. Zhang ◽  
J. Li ◽  
R. O. Compton ◽  
J. Robertson ◽  
V. H. Goff ◽  
...  
Keyword(s):  
Seed Size ◽  
Comparative Genetics

The comparative genetics of Phytophthora

EPPO Bulletin ◽  
1990 ◽  
Vol 20 (1) ◽  
pp. 67-76
Author(s):  
D. S. SHAW
Keyword(s):  
Comparative Genetics

SSCP-SNP in pearl millet—a new marker system for comparative genetics

2005 ◽  
Vol 110 (8) ◽  
pp. 1467-1472 ◽  
Author(s):  
I. Bertin ◽  
J. H. Zhu ◽  
M. D. Gale
Keyword(s):  
Pearl Millet ◽  
Comparative Genetics ◽  
Marker System
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