scholarly journals Maximal Ca2+-activated force and myofilament Ca2+ sensitivity in intact mammalian hearts. Differential effects of inorganic phosphate and hydrogen ions.

1987 ◽  
Vol 90 (5) ◽  
pp. 609-623 ◽  
Author(s):  
E Marban ◽  
H Kusuoka
Keyword(s):  
Inorganic Phosphate ◽  
Hydrogen Ion ◽  
Hydrogen Ions ◽  
Intact Tissue ◽  
Fundamental Properties ◽  
Skinned Muscle ◽  
Novel Approach ◽  
Nuclear Magnetic Resonance Spectra ◽  
Maximal Pressure ◽  
The One

Myofilament Ca2+ sensitivity and maximal Ca2+-activated force are fundamental properties of the contractile proteins in the heart. Although these properties can be evaluated directly in skinned preparations, they have remained elusive in intact tissue. A novel approach is described that allows maximal Ca2+-activated force to be measured and myofilament Ca2+ sensitivity to be deduced from isovolumic pressure in intact perfused ferret hearts. Phosphorus nuclear magnetic resonance spectra are obtained sequentially to measure the intracellular inorganic phosphate (Pi) and hydrogen ion (H+) concentrations. After a period of perfusion with oxygenated, HEPES-buffered Tyrode solution, hypoxia is induced as a means of elevating [Pi]. The decline in twitch pressure can then be related to the measured increase in [Pi]. After recovery, hearts are perfused with ryanodine to enable tetanization and the measurement of maximal Ca2+-activated pressure. Hypoxia is induced once again, and maximal pressure is correlated with [Pi]. We then compare the relations between [Pi] and maximal pressure on the one hand, and [Pi] and twitch pressure on the other. If the two relations differ only by a constant scaling factor, then the decline in twitch pressure can be attributed solely to a decline in maximal pressure, with no change in myofilament sensitivity. We obtained such a result during hypoxia, which indicated that Pi accumulation decreases maximal force but does not change myofilament sensitivity. We compared these results with acidosis (induced by bubbling with 5% CO2). In contrast with Pi, the accumulation of H+ decreases twitch force primarily by shifting myofilament Ca2+ sensitivity. This approach in intact tissue has strengths and limitations complementary to those of skinned muscle experiments.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

scholarly journals A novel approach to the computation of one-loop three- and four-point functions: I. The real mass case

2019 ◽  
Vol 2019 (11) ◽  
Author(s):  
J Ph Guillet ◽  
E Pilon ◽  
Y Shimizu ◽  
M S Zidi
Keyword(s):  
Building Blocks ◽  
The Real ◽  
Alternative Method ◽  
Novel Approach ◽  
Reduction Methods ◽  
Real Mass ◽  
Novel Method ◽  
Algebraic Reduction ◽  
The One ◽  
Mass Case

Abstract This article is the first of a series of three presenting an alternative method of computing the one-loop scalar integrals. This novel method enjoys a couple of interesting features as compared with the method closely following ’t Hooft and Veltman adopted previously. It directly proceeds in terms of the quantities driving algebraic reduction methods. It applies to the three-point functions and, in a similar way, to the four-point functions. It also extends to complex masses without much complication. Lastly, it extends to kinematics more general than that of the physical, e.g., collider processes relevant at one loop. This last feature may be useful when considering the application of this method beyond one loop using generalized one-loop integrals as building blocks.

scholarly journals Tenebrio molitor in the circular economy: a novel approach for plastic valorisation and PHA biological recovery

2021 ◽  
Author(s):  
Paola Sangiorgio ◽  
Alessandra Verardi ◽  
Salvatore Dimatteo ◽  
Anna Spagnoletta ◽  
Stefania Moliterni ◽  
...  
Keyword(s):  
Circular Economy ◽  
Raw Materials ◽  
Economic Value ◽  
Tenebrio Molitor ◽  
World Population ◽  
Plastic Pollution ◽  
Biological Recovery ◽  
Great Opportunity ◽  
Novel Approach ◽  
The One

AbstractThe increase in the world population leads to rising demand and consumption of plastic raw materials; only a small percentage of plastics is recovered and recycled, increasing the quantity of waste released into the environment and losing its economic value. The plastics represent a great opportunity in the circular perspective of their reuse and recycling. Research is moving, on the one hand, to implement sustainable systems for plastic waste management and on the other to find new non-fossil-based plastics such as polyhydroxyalkanoates (PHAs). In this review, we focus our attention on Tenebrio molitor (TM) as a valuable solution for plastic biodegradation and biological recovery of new biopolymers (e.g. PHA) from plastic-producing microorganisms, exploiting its highly diversified gut microbiota. TM’s use for plastic pollution management is controversial. However, TM microbiota is recognised as a source of plastic-degrading microorganisms. TM-based plastic degradation is improved by co-feeding with food loss and waste as a dietary energy source, thus valorising these low-value substrates in a circular economy perspective. TM as a bioreactor is a valid alternative to traditional PHA recovery systems with the advantage of obtaining, in addition to highly pure PHA, protein biomass and rearing waste from which to produce fertilisers, chitin/chitosan, biochar and biodiesel. Finally, we describe the critical aspects of these TM-based approaches, mainly related to TM mass production, eventual food safety problems, possible release of microplastics and lack of dedicated legislation.

Hydrogen Ion Beam Processing of Single Crystal Diamond Chips

1994 ◽  
Vol 354 ◽  
Author(s):  
Shuji Kiyohara ◽  
Iwao Miyamoto
Keyword(s):  
Surface Roughness ◽  
Single Crystal ◽  
Incidence Angle ◽  
Ion Beam ◽  
Etching Rate ◽  
Hydrogen Ion ◽  
Hydrogen Ions ◽  
Ion Beam Etching ◽  
Single Crystal Diamond ◽  
Before And After

AbstractIn order to apply ion beam etching with hydrogen ions to the ultra-precision processing of diamond tools, hydrogen ion beam etching characteristics of single crystal diamond chips with (100) face were investigated. The etching rate of diamond for 500 eV and 1000 eV hydrogen ions increases with the increase of the ion incidence angle, and eventually reaches a maximum at the ion incidence angle of approximately 50°, then may decrease with the increase of the ion incidence angle. The dependence of the etching rate on the ion incidence angle of hydrogen ions is fairly similar to that obtained with argon ions. Furthermore, the surface roughness of diamond chips before and after hydrogen ion beam etching was evaluated using an atomic force microscope. Consequently, the surface roughness after hydrogen ion beam etching decreases with the increase of the ion incidence angle within range of the ion incidence angle of 60°.

scholarly journals A Novel Approach to the Analysis of the Soil Consolidation Problem by Using Non-Classical Rheological Schemes

2021 ◽  
Vol 11 (5) ◽  
pp. 1980
Author(s):  
Kazimierz Józefiak ◽  
Artur Zbiciak ◽  
Karol Brzeziński ◽  
Maciej Maślakowski
Keyword(s):  
Constitutive Models ◽  
Organic Soil ◽  
Organic Soils ◽  
Soil Consolidation ◽  
Flexible Tool ◽  
One Dimensional ◽  
Novel Approach ◽  
Soil Skeleton ◽  
The One ◽  
The Relationship

The paper presents classical and non-classical rheological schemes used to formulate constitutive models of the one-dimensional consolidation problem. The authors paid special attention to the secondary consolidation effects in organic soils as well as the soil over-consolidation phenomenon. The systems of partial differential equations were formulated for every model and solved numerically to obtain settlement curves. Selected numerical results were compared with standard oedometer laboratory test data carried out by the authors on organic soil samples. Additionally, plasticity phenomenon and non-classical rheological elements were included in order to take into account soil over-consolidation behaviour in the one-dimensional settlement model. A new way of formulating constitutive equations for the soil skeleton and predicting the relationship between the effective stress and strain or void ratio was presented. Rheological structures provide a flexible tool for creating complex constitutive relationships of soil.

A Novel Algorithm for Sentiment Analysis of Online Movie Reviews

2018 ◽  
pp. 106-140
Author(s):  
Bisma Shah ◽  
Farheen Siddiqui
Keyword(s):  
Sentiment Analysis ◽  
Nearest Neighbor ◽  
Supervised Machine Learning ◽  
Learning Approaches ◽  
World Knowledge ◽  
K Nearest Neighbor ◽  
Customer Feedback ◽  
Novel Approach ◽  
The One ◽  
Novel Algorithm

Others' opinions can be decisive while choosing among various options, especially when those choices involve worthy resources like spending time and money buying products or services. Customers relying on their peers' past reviews on e-commerce websites or social media have drawn a considerable interest to sentiment analysis due to realization of its commercial and business benefits. Sentiment analysis can be exercised on movie reviews, blogs, customer feedback, etc. This chapter presents a novel approach to perform sentiment analysis of movie reviews given by users on different websites. Also, challenges like presence of thwarted words, world knowledge, and subjectivity detection in sentiments are addressed in this chapter. The results are validated by using two supervised machine learning approaches, k-nearest neighbor and naive Bayes, both on method of sentiment analysis without addressing aforementioned challenges and on proposed method of sentiment analysis with all challenges addressed. Empirical results show that proposed method outperformed the one that left challenges unaddressed.

Reactions with Hydrogen Ions

1997 ◽  
Author(s):  
F. S. Zhang ◽  
T. R. Yu
Keyword(s):  
Ionization Energy ◽  
Alkali Metals ◽  
Chemical Properties ◽  
Hydrogen Ion ◽  
Hydrogen Ions ◽  
Soil Particles ◽  
Variable Charge ◽  
Hydrated Proton ◽  
Characteristic Features ◽  
Variable Charge Soils

Hydrogen ion is one kind of cation which possesses many properties common to all cations. Hydrogen ion also has its own characteristic features which are of particular significance for variable charge soils. The interactions between hydrogen ions and the surface of soil particles is the basic cause of the variability of both positive and negative surface charges of variable charge soils. The quantity of hydrogen ions in soils determines the acidity of the soil while the acidity of variable charge soils is among the strongest in all the soils. This strong acidity of variable charge soils affects many other chemical properties of the soil. In this chapter, the basic properties of hydrogen ions will be briefly discussed. Then, the products and the kinetics of the interaction between hydrogen ions and variable charge soils will be treated. The dissociation of hydrogen ions from the surface of soil particles has already been mentioned in Chapter 2. After the dissociation of an electron, a hydrogen atom becomes a proton (H+ ion). The ionization energy of hydrogen atoms is 1310 kj mol-1, whereas those of alkali metals, Li, Na, K, and Cs, are 519, 494, 419 and 377 kj mol-1, respectively. This difference in the ionization energy between hydrogen and alkali metals indicates that protons have a particularly strong affinity for electrons. Therefore, protons are apt to form a covalent bond with other atoms by sharing a pair of electrons, or to form a hydrogen bond. Because of the absence of an electronic shell, a proton has a diameter of the order of 10-13 cm, while other ions with electronic shells generally have a diameter of the order of 10-8 cm. Because a proton is so small, it is quite accessible to its neighboring ions and molecules. Therefore, there is very little steric hindrance when protons participate in chemical reactions. The above-mentioned features of proton are the basis for its particular properties. Free proton in solution is extremely unstable because it is very active. In an aqueous solution it will react with water molecules to form a hydrated proton, H3O+.

A Novel Approach for Business Process Model Matching Using Genetic Algorithms

2020 ◽  
Vol 12 (1) ◽  
pp. 1-19
Author(s):  
Mostefai Abdelkader ◽  
Ignacio García Rodríguez de Guzmán
Keyword(s):  
Genetic Algorithms ◽  
Business Process ◽  
Process Model ◽  
Optimization Problem ◽  
Process Models ◽  
Similarity Metrics ◽  
Model Matching ◽  
Matching Problem ◽  
Novel Approach ◽  
The One

This paper formulates the process model matching problem as an optimization problem and presents a heuristic approach based on genetic algorithms for computing a good enough alignment. An alignment is a set of not overlapping correspondences (i.e., pairs) between two process models(i.e., BP) and each correspondence is a pair of two sets of activities that represent the same behavior. The first set belongs to a source BP and the second set to a target BP. The proposed approach computes the solution by searching, over all possible alignments, the one that maximizes the intra-pairs cohesion while minimizing inter-pairs coupling. Cohesion of pairs and coupling between them is assessed using a proposed heuristic that combines syntactic and semantic similarity metrics. The proposed approach was evaluated on three well-known datasets. The results of the experiment showed that the approach has the potential to match business process models effectively.

Source Camera Identification Based on Sensor Readout Noise

2010 ◽  
Vol 2 (3) ◽  
pp. 28-42 ◽  
Author(s):  
H. R. Chennamma ◽  
Lalitha Rangarajan
Keyword(s):  
Computer Software ◽  
Sensor Data ◽  
Processing Parameter ◽  
Source Camera Identification ◽  
Camera Identification ◽  
Novel Approach ◽  
Deviation Plot ◽  
Readout Noise ◽  
The One ◽  
Imaging Sensor

A digitally developed image is a viewable image (TIFF/JPG) produced by a camera’s sensor data (raw image) using computer software tools. Such images might use different colour space, demosaicing algorithms or by different post processing parameter settings which are not the one coded in the source camera. In this regard, the most reliable method of source camera identification is linking the given image with the sensor of camera. In this paper, the authors propose a novel approach for camera identification based on sensor’s readout noise. Readout noise is an important intrinsic characteristic of a digital imaging sensor (CCD or CMOS) and it cannot be removed. This paper quantitatively measures readout noise of the sensor from an image using the mean-standard deviation plot, while in order to evaluate the performance of the proposed approach, the authors tested against the images captured at two different exposure levels. Results show datasets containing 1200 images acquired from six different cameras of three different brands. The success of proposed method is corroborated through experiments.

scholarly journals Mechanics and thermodynamics of a new minimal model of the atmosphere

2020 ◽  
Vol 135 (10) ◽  
Author(s):  
Gabriele Vissio ◽  
Valerio Lucarini
Keyword(s):  
Numerical Models ◽  
Preliminary Evidence ◽  
Chaotic Motions ◽  
One Dimensional ◽  
Fundamental Properties ◽  
Multiscale Dynamics ◽  
Energy Cycle ◽  
The One ◽  
Lorenz 96 ◽  
Model Features

AbstractThe understanding of the fundamental properties of the climate system has long benefitted from the use of simple numerical models able to parsimoniously represent the essential ingredients of its processes. Here, we introduce a new model for the atmosphere that is constructed by supplementing the now-classic Lorenz ’96 one-dimensional lattice model with temperature-like variables. The model features an energy cycle that allows for energy to be converted between the kinetic form and the potential form and for introducing a notion of efficiency. The model’s evolution is controlled by two contributions—a quasi-symplectic and a gradient one, which resemble (yet not conforming to) a metriplectic structure. After investigating the linear stability of the symmetric fixed point, we perform a systematic parametric investigation that allows us to define regions in the parameters space where at steady-state stationary, quasi-periodic, and chaotic motions are realised, and study how the terms responsible for defining the energy budget of the system depend on the external forcing injecting energy in the kinetic and in the potential energy reservoirs. Finally, we find preliminary evidence that the model features extensive chaos. We also introduce a more complex version of the model that is able to accommodate for multiscale dynamics and that features an energy cycle that more closely mimics the one of the Earth’s atmosphere.

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