scholarly journals Physical Variables in the Olfactory Stimulation Process

1963 ◽  
Vol 46 (3) ◽  
pp. 453-489 ◽  
Author(s):  
Don Tucker
Keyword(s):  
Flow Rate ◽  
Volume Flow Rate ◽  
Olfactory Receptors ◽  
Aqueous Solubility ◽  
Amyl Acetate ◽  
Olfactory Responses ◽  
Flow Dependence ◽  
Receptor Sites ◽  
Physical Variables ◽  
Intrinsic Variable

Electrical recording from small twigs of nerve in a tortoise showed that olfactory, vomeronasal, and trigeminal receptors in the nose are responsive to various odorants. No one kind of receptor was most sensitive to all odorants. For controlled stimulation, odorant was caused to appear in a stream of gas already flowing through the nose. Of the parameters definable at the naris, temperature, relative humidity, and nature of inert gas had little effect on olfactory responses to amyl acetate, whereas odorant species, odorant concentration, and volume flow rate effectively determined the responses of all nasal chemoreceptors. An intrinsic variable of accessibility to the receptors, particularly olfactory, was demonstrated. Flow dependence of chemoreceptor responses is thought to reflect the necessity for delivery of odorant molecules to receptor sites. Since the olfactory receptors are relatively exposed, plateauing of the response with flow rate for slightly soluble odorants suggests an approach to concentration equilibrium in the overlying mucus with that in the air entering the naris. Accordingly, data for responses to amyl acetate were fitted with Beidler's (1954) taste equation for two kinds of sites being active. The requirement for finite aqueous solubility, if true, suggests substitution of aqueous solutions for gaseous solutions. A suitable medium was found and results conformed to expectations. Olfactory receptors were insensitive to variation of ionic strength, pH, and osmotic pressure.

Novel epoxy/anhydride alternatives for biological electron microscopy: Physical and performance characteristis of embed 812 and LX 112 in combination with NSA/NMA/DMAE

1989 ◽  
Vol 47 ◽  
pp. 1000-1001
Author(s):  
Joe A. Mascorro ◽  
Gerald S. Kirby
Keyword(s):  
Electron Microscopy ◽  
Flow Rate ◽  
Succinic Anhydride ◽  
Volume Flow Rate ◽  
Mass Density ◽  
Uranyl Acetate ◽  
Volume Flow ◽  
Base Resin ◽  
And Performance ◽  
Acid Anhydrides

Embedding media based upon an epoxy resin of choice and the acid anhydrides dodecenyl succinic anhydride (DDSA), nadic methyl anhydride (NMA), and catalyzed by the tertiary amine 2,4,6-Tri(dimethylaminomethyl) phenol (DMP-30) are widely used in biological electron microscopy. These media possess a viscosity character that can impair tissue infiltration, particularly if original Epon 812 is utilized as the base resin. Other resins that are considerably less viscous than Epon 812 now are available as replacements. Likewise, nonenyl succinic anhydride (NSA) and dimethylaminoethanol (DMAE) are more fluid than their counterparts DDSA and DMP- 30 commonly used in earlier formulations. This work utilizes novel epoxy and anhydride combinations in order to produce embedding media with desirable flow rate and viscosity parameters that, in turn, would allow the medium to optimally infiltrate tissues. Specifically, embeding media based on EmBed 812 or LX 112 with NSA (in place of DDSA) and DMAE (replacing DMP-30), with NMA remaining constant, are formulated and offered as alternatives for routine biological work.Individual epoxy resins (Table I) or complete embedding media (Tables II-III) were tested for flow rate and viscosity. The novel media were further examined for their ability to infilftrate tissues, polymerize, sectioning and staining character, as well as strength and stability to the electron beam and column vacuum. For physical comparisons, a volume (9 ml) of either resin or media was aspirated into a capillary viscocimeter oriented vertically. The material was then allowed to flow out freely under the influence of gravity and the flow time necessary for the volume to exit was recored (Col B,C; Tables). In addition, the volume flow rate (ml flowing/second; Col D, Tables) was measured. Viscosity (n) could then be determined by using the Hagen-Poiseville relation for laminar flow, n = c.p/Q, where c = a geometric constant from an instrument calibration with water, p = mass density, and Q = volume flow rate. Mass weight and density of the materials were determined as well (Col F,G; Tables). Infiltration schedules utilized were short (1/2 hr 1:1, 3 hrs full resin), intermediate (1/2 hr 1:1, 6 hrs full resin) , or long (1/2 hr 1:1, 6 hrs full resin) in total time. Polymerization schedules ranging from 15 hrs (overnight) through 24, 36, or 48 hrs were tested. Sections demonstrating gold interference colors were collected on unsupported 200- 300 mesh grids and stained sequentially with uranyl acetate and lead citrate.

scholarly journals Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli

2010 ◽  
Vol 298 (1) ◽  
pp. F177-F186 ◽  
Author(s):  
Anne D. M. Riquier-Brison ◽  
Patrick K. K. Leong ◽  
Kaarina Pihakaski-Maunsbach ◽  
Alicia A. McDonough
Keyword(s):  
Angiotensin Ii ◽  
Proximal Tubule ◽  
Flow Rate ◽  
Enzyme Inhibitor ◽  
Volume Flow Rate ◽  
Ang Ii ◽  
Sprague Dawley ◽  
Water Reabsorption ◽  
Associated Proteins ◽  
Gradient Fractionation

Angiotensin II (ANG II) stimulates proximal tubule (PT) sodium and water reabsorption. We showed that treating rats acutely with the angiotensin-converting enzyme inhibitor captopril decreases PT salt and water reabsorption and provokes rapid redistribution of the Na+/H+ exchanger isoform 3 (NHE3), Na+/Pi cotransporter 2 (NaPi2), and associated proteins out of the microvilli. The aim of the present study was to determine whether acute ANG II infusion increases the abundance of PT NHE3, NaPi2, and associated proteins in the microvilli available for reabsorbing NaCl. Male Sprague-Dawley rats were infused with a dose of captopril (12 μg/min for 20 min) that increased PT flow rate ∼20% with no change in blood pressure (BP) or glomerular filtration rate (GFR). When ANG II (20 ng·kg−1·min−1 for 20 min) was added to the captopril infusate, PT volume flow rate returned to baseline without changing BP or GFR. After captopril, NHE3 was localized to the base of the microvilli and NaPi2 to subapical cytoplasmic vesicles; after 20 min ANG II, both NHE3 and NaPi2 redistributed into the microvilli, assayed by confocal microscopy and density gradient fractionation. Additional PT proteins that redistributed into low-density microvilli-enriched membranes in response to ANG II included myosin VI, DPPIV, NHERF-1, ezrin, megalin, vacuolar H+-ATPase, aminopeptidase N, and clathrin. In summary, in response to 20 min ANG II in the absence of a change in BP or GFR, multiple proteins traffic into the PT brush-border microvilli where they likely contribute to the rapid increase in PT salt and water reabsorption.

Multi-objective optimization of squirrel cage fan for range hood based on Kriging model

2021 ◽  
pp. 095440622199586
Author(s):  
Qianhao Xiao ◽  
Jun Wang ◽  
Boyan Jiang ◽  
Weigang Yang ◽  
Xiaopei Yang
Keyword(s):  
Flow Rate ◽  
Optimization Design ◽  
Volume Flow Rate ◽  
Kriging Model ◽  
Volume Flow ◽  
Design Parameters ◽  
Multi Objective Optimization ◽  
Nsga Ii ◽  
Multi Objective ◽  
Squirrel Cage

In view of the multi-objective optimization design of the squirrel cage fan for the range hood, a blade parameterization method based on the quadratic non-uniform B-spline (NUBS) determined by four control points was proposed to control the outlet angle, chord length and maximum camber of the blade. Morris-Mitchell criteria were used to obtain the optimal Latin hypercube sample based on the evolutionary operation, and different subsets of sample numbers were created to study the influence of sample numbers on the multi-objective optimization results. The Kriging model, which can accurately reflect the response relationship between design variables and optimization objectives, was established. The second-generation Non-dominated Sorting Genetic algorithm (NSGA-II) was used to optimize the volume flow rate at the best efficiency point (BEP) and the maximum volume flow rate point (MVP). The results show that the design parameters corresponding to the optimization results under different sample numbers are not the same, and the fluctuation range of the optimal design parameters is related to the influence of the design parameters on the optimization objectives. Compared with the prototype, the optimized impeller increases the radial velocity of the impeller outlet, reduces the flow loss in the volute, and increases the diffusion capacity, which improves the volume flow rate, and efficiency of the range hood system under multiple working conditions.

scholarly journals Influence of Magnetic Field on the Peristaltic Flow of a Viscous Fluid through a Finite-Length Cylindrical Tube

2010 ◽  
Vol 7 (3) ◽  
pp. 169-176 ◽  
Author(s):  
S. K. Pandey ◽  
Dharmendra Tripathi
Keyword(s):  
Magnetic Field ◽  
Viscous Fluid ◽  
Transverse Magnetic Field ◽  
Finite Length ◽  
Flow Rate ◽  
Hartmann Number ◽  
Volume Flow Rate ◽  
Critical Value ◽  
Transverse Magnetic ◽  
Volume Flow

The paper presents an analytical investigation of the peristaltic transport of a viscous fluid under the influence of a magnetic field through a tube of finite length in a dimensionless form. The expressions of pressure gradient, volume flow rate, average volume flow rate and local wall shear stress have been obtained. The effects of the transverse magnetic field and electrical conductivity (i.e. the Hartmann number) on the mechanical efficiency of a peristaltic pump have also been studied. The reflux phenomenon is also investigated. It is concluded, on the basis of the pressure distribution along the tubular length and pumping efficiency, that if the transverse magnetic field and the electric conductivity increase, the pumping machinery exerts more pressure for pushing the fluid forward. There is a linear relation between the averaged flow rate and the pressure applied across one wavelength that can restrain the flow due to peristalsis. It is found that there is a particular value of the averaged flow rate corresponding to a particular pressure that does not depend on the Hartmann number. Naming these values ‘critical values’, it is concluded that the pressure required for checking the flow increases with the Hartmann number above the critical value and decreases with it below the critical value. It is also inferred that magneto-hydrodynamic parameters make the fluid more prone to flow reversal. The conclusion applied to oesophageal swallowing reveals that normal water is easier to swallow than saline water. The latter is more prone to flow reversal. A significant difference between the propagation of the integral and non-integral number of waves along the tube is that pressure peaks are identical in the former and different in the latter cases.

3D Flow Simulation of a Twin-Screw Pump for the Analysis of Gap Flow Characteristics

2021 ◽  
Author(s):  
Ali Hassannejadmoghaddam ◽  
Boris Kutschelis ◽  
Frank Holz ◽  
Tomas Börjesson ◽  
Romuald Skoda
Keyword(s):  
Flow Rate ◽  
Volume Flow Rate ◽  
Overset Grid ◽  
3D Flow ◽  
Screw Pump ◽  
Pump Performance ◽  
Gap Flow ◽  
Wide Range ◽  
Twin Screw ◽  
Pump Head

Abstract Unsteady 3D flow simulations on a twin-screw pump are performed for an assessment of the radial, circumferential and flank gap flow effect on the pump performance. By means of the overset grid technique rigid computational grids around the counter-rotating spindles yield a high cell quality and a high spatial resolution of the gap backflow down to the viscous sublayer in terms of y^+ < 1 . An optimization of the hole-cutting process is performed on a generic gap flow and transferred to the complex moving gaps in the pump. Grid independence is ensured, and conservation properties of the overset grid interpolation technique are assessed. Simulation results are validated against measured pump characteristics. Pump performance in terms of pressure build-up along the flow path through the spindles and volume flow rate is presented for a wide range of spindle speed and pump head. Flow rate fluctuations are found to depend on head but hardly on speed. By a profound assessment of the respective radial, circumferential and flank gap contribution to the total backflow, the importance of the most complex flank gap is pointed out. Backflow rate characteristics in dependence on the pump head and the pump speed are presented.

Partial Admission, Axial Impulse Type Turbine Design and Partial Admission Radial Turbine Test for SCO2 Cycle

2017 ◽  
Author(s):  
Hyungki Shin ◽  
Junhyun Cho ◽  
Young-Jin Baik ◽  
Jongjae Cho ◽  
Chulwoo Roh ◽  
...  
Keyword(s):  
Axial Force ◽  
Flow Rate ◽  
Volume Flow Rate ◽  
Small Diameter ◽  
Volume Flow ◽  
Working Fluid ◽  
Rotating Speed ◽  
Turbo Generator ◽  
Partial Admission ◽  
Reduce Development Time

Power generation cycle — typically Brayton cycle — to use CO2 at supercritical state as working fluid have been researched many years because this cycle increase thermal efficiency of cycle and decrease turbomachinery size. But small turbomachinery make it difficult to develop proto type Supercritical Carbon dioxide (S-CO2) cycle equipment of lab scale size. KIER (Korea Institute of Energy Research) have been researched S-CO2 cycle since 2013. This paper is about 60kWe scale and sub-kWe class turbo generator development for applying to this S-CO2 cycle at the lab scale. A design concept of this turbo-generator is to use commercially available components so as to reduce development time and increase reliability. Major problem of SCO2 turbine is small volume flow rate and huge axial force. High density S-CO2 was referred as advantage of S-CO2 cycle because it make small turbomachinery possible. But this advantage was not valid in lab-scale cycles under 100kW because small amount volume flow rate means high rotating speed and too small diameter of turbine to manufacture it. Also, high inlet and outlet pressure make huge axial force. To solve these problem, KIER have attempt various turbines. In this paper, these attempts and results are presented and discussed.

The Effect of Air Injection Method on the Airlift Pump Performance

2012 ◽  
Vol 134 (11) ◽  
Author(s):  
Dong Hu ◽  
Chuan-Lin Tang ◽  
Shu-Peng Cai ◽  
Feng-Hua Zhang
Keyword(s):  
Flow Rate ◽  
Volume Flow Rate ◽  
Low Cost ◽  
Air Injection ◽  
Water Volume ◽  
Pump Design ◽  
Pump Performance ◽  
Dimensionless Equation ◽  
Measurement Results ◽  
Injection Methods

With simple structure, excellent reliability, low cost, no restriction at depth of water, and easy control and operation, airlift pumps have special advantage in borehole hydraulic jet mining, river dredging and deep sea mining. To clarify the mechanism and process of action of air injection methods on air lift performance, and to enhance lifting capacity, the pump performance of a small airlift system in transporting river sands is investigated experimentally in the present study. The results are as the follows. The influences of air exit ports on water volume flow rate, mass flow rate of solids and lifting efficiency are studied and found to be very low when the number of air exit ports exceeds 3. The pump design show best pumping capability for water and solids at higher air flow rates, but the lifting efficiency is then very low. In addition, a dimensionless equation which describes the flows in the pipe is presented based on the Bernoulli equation, and compared with measurement results in the dimensionless form, which are nearly in good agreement with each other for all the arrangements of air exit ports and are basically contained within ±18% of the theoretical curve. The results are important for understanding the mechanism of airlift pumps and enriching multiphase flow theory.

Numerical Simulation on Air Volume Flow Rate Distribution of Stator Ducts for Salient Pole Synchronous Motor

2014 ◽  
Vol 644-650 ◽  
pp. 373-376
Author(s):  
Li Liu ◽  
Yi Ping Lu ◽  
Jia De Han ◽  
Xue Mei Sun
Keyword(s):  
Flow Rate ◽  
Volume Flow Rate ◽  
Domain Boundary ◽  
Air Flow ◽  
Flow Characteristics ◽  
Synchronous Motor ◽  
Volume Flow ◽  
Rate Distribution ◽  
Salient Pole ◽  
Air Volume

Air volume flow rate distribution of stator ducts along axial and circumferential for salient pole synchronous motor is strongly influenced by the air flow field in the air gap and rotor poles, which is completely different from the flow characteristics of non-salient pole motor and it directly relates to the peak temperature of stator bars and core and axial temperature difference which can affect the safety of the operation. A three-dimensional physical model of 1/8 motor was established and corresponding solution domain boundary conditions were given in this article. The air volume flow rate distribution of stator ducts along axial and circumferential was analyzed based on CFD. The study show that at the same position of the axial stator, the cooling air flow into stator ducts along the circumferential direction is uneven, the air volume flow rate distribution is largely influenced by rotor pole pieces, geometry and position of pole support block and rotor rotation direction.

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