scholarly journals Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases

2013 ◽  
Vol 143 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Marco Conti ◽  
Delphine Mika ◽  
Wito Richter
Keyword(s):  
Cyclic Amp ◽  
Cyclic Nucleotide ◽  
Signaling Specificity ◽  
Cyclic Nucleotide Phosphodiesterases ◽  
Nucleotide Phosphodiesterases

scholarly journals Simulations of the roles of multiple cyclic nucleotide phosphodiesterases

1982 ◽  
Vol 202 (1) ◽  
pp. 125-132 ◽  
Author(s):  
C H Reynolds
Keyword(s):  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Cyclic Nucleotide ◽  
Maximum Velocity ◽  
Maximal Activity ◽  
Hormone Concentration ◽  
Response Curves ◽  
Cyclic Nucleotide Phosphodiesterases ◽  
Michaelis Constants ◽  
Nucleotide Phosphodiesterases

1. Simulations were performed using a model for cellular cyclic AMP metabolism involving a hormone-activated adenylate cyclase and two cyclic nucleotide phosphodiesterases with different Michaelis constants. 2. The response curves of cyclic AMP concentration as a function of hormone concentration were affected by regulating the phosphodiesterases. The maximum velocity of the high-affinity phosphodiesterase (V1) was important in determining the position of the response curve; when v1 was less than the maximal activity of adenylate cyclase (Vc), sigmoid response curves were readily produced. The maximum attainable concentration of cyclic AMP was determined primarily by V1 when Vc less than V1, and primarily by the activity of the low-affinity enzyme when Vc greater than V1 (V2 much greater than Vc in all cases). 3. The glucagon-stimulated adenylate cyclase and insulin-stimulated phosphodiesterase of the rat liver plasma membrane were simulated using experimentally determined values for the enzyme-kinetic parameters, and a considerable potential for regulation of the system by insulin was demonstrated. 4. Other possible functions for the regulation of phosphodiesterases are considered, in particular the value of increasing the speed of response to decreases in hormone concentration.

scholarly journals Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Chen Yan
Keyword(s):  
Cyclic Amp ◽  
Cyclic Gmp ◽  
Cyclic Nucleotide ◽  
Myelin Formation ◽  
Cyclic Nucleotide Phosphodiesterases ◽  
Ic50 Value ◽  
Hydrolysis Of ◽  
Nucleotide Phosphodiesterases

3',5'-Cyclic nucleotide phosphodiesterases (PDEs, 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3',5'-cyclic nucleotide (usually cyclic AMP or cyclic GMP). isobutylmethylxanthine is a nonselective inhibitor with an IC50 value in the millimolar range for all isoforms except PDE 8A, 8B and 9A. A 2',3'-cyclic nucleotide 3'-phosphodiesterase (E.C. 3.1.4.37 CNPase) activity is associated with myelin formation in the development of the CNS.

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