scholarly journals THE MOVEMENT OF WATER IN TUMOR TISSUE REMOVED FROM THE BODY

1949 ◽  
Vol 89 (2) ◽  
pp. 209-222 ◽  
Author(s):  
Eugene L. Opie
Keyword(s):  
Sodium Chloride ◽  
Tumor Cells ◽  
Liver Tissue ◽  
Water Exchange ◽  
Subcutaneous Tissue ◽  
Fibrous Tissue ◽  
Normal Liver ◽  
Liver Cells ◽  
The Body ◽  
Normal Liver Tissue

When immersed in water cells of hepatomas produced by p-dimethyl-aminoazobenzene (butter yellow) take in less water than liver cells from which they are derived and more rapidly undergo disintegration; cholangiomas produced by butter yellow undergo similar changes. As a result of the injury of the tumor cells by water the osmotic exchange, characteristic of the normal liver cells under the same conditions, is impaired within the initial half hour of immersion. Solutions of sodium chloride isotonic for hepatoma tissue have a concentration approximating 0.16 molar and for cholangioma, 0.2 molar, whereas solutions isotonic for normal liver tissue approximate 0.34 molar. Water exchange of hepatoma and of cholangioma tissue in solutions of sodium chloride of various concentrations deviates from a proportional relation to the concentration more than does normal liver tissue under the same conditions. Water exchange of sarcoma of the subcutaneous tissue produced by benzpyrene when immersed in water resembles that of interstitial fibrous tissue of normal animals, but by the procedures that have been used water exchange of the tumor cells alone has not been measurable. Microscopic examination indicates that the sarcoma cells are as susceptible to injury as those of the other tumors that have been examined. Intake of water by adenofibromas of the subcutaneous tissue is apparently dominated by changes in the dense stroma of the tumor and has the anomalous character of intake bycompact fibrous tissue of the corium of the skin and of the wall of the aorta.

scholarly journals THE MOVEMENT OF WATER IN TISSUES REMOVED FROM THE BODY AND ITS RELATION TO MOVEMENT OF WATER DURING LIFE

1949 ◽  
Vol 89 (2) ◽  
pp. 185-208 ◽  
Author(s):  
Eugene L. Opie
Keyword(s):  
Sodium Chloride ◽  
Blood Serum ◽  
Water Exchange ◽  
Initial Period ◽  
Fibrous Tissue ◽  
The Body ◽  
Molar Concentration ◽  
Interstitial Tissue ◽  
Square Root ◽  
Elapsed Time

During the initial period following immersion of parenchymatous cells of liver, kidney, or pancreas in various fluids immediately after their removal from the body water exchange is like that which occurs when water passes by osmosis through a semipermeable membrane; intake of water is proportional to the square root of the elapsed time and when liver tissue is immersed in solutions of sodium chloride movement of water is approximately proportional to the concentration of the solution. Solutions of sodium chloride isotonic for parenchymatous cells of liver have twice the molar concentration of sodium chloride in the blood serum; for those of the kidney slightly less than twice and for those of the pancreas three times this concentration. When interstitial tissue of thymus, omentum, or pancreas is immersed in water, it undergoes edema-like swelling caused by hydration of the colloids of the fibrous tissue; quantitative water exchange in an initial period accords with water movement by osmosis and is proportional to the square root of the elapsed time. Solutions of sodium chloride isotonic for fibrous tissue of the omentum have slightly greater molar concentration than the sodium chloride in the blood serum and for that of the thymus approximately the same as that of blood serum. Sodium chloride produces changes in fibrous tissue which increase with increasing concentration its power to hold water; the dense fibrous tissue of the corium of the skin and of the wall of the aorta takes up water in both weak an strong solutions of sodium chloride. The initial movement of water induced in tissues in the period immediately following removal from the body is dependent upon forces which are active during life but soon impaired by injury to the tissues. The molar concentration of the contents of secreting cells is greater than that of the blood serum and of the fluid surrounding them. These conditions are favorable to the passage of water from the tissue spaces to the cells.

scholarly journals Effect of Intrahepatic Arterial Delivery of Sorafenib on Normal Liver Tissue of Rabbit: An Experimental Study

2020 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Eerdunbagena Ning ◽  
Zhijun Wang
Keyword(s):  
Heart Rate ◽  
Rectal Temperature ◽  
Liver Tissue ◽  
High Performance ◽  
Arterial Embolization ◽  
Hepatic Arterial Infusion ◽  
Normal Liver ◽  
Normal Liver Tissue ◽  
Breathing Rate ◽  
Local Necrosis

Objective: To assess the safety, feasibility and eluting efficiency of intrahepatic arterial delivery of sorafenib on normal liver tissue of rabbit. Methods: 24 New Zealand rabbits were randomly divided into three groups: group Ⅰ (Lipiodol-sorafenid), group Ⅱ (Lipiodol) and group Ⅲ (Sorafenib). Group Ⅰ and Ⅱ were treated by transcatheter selective hepatic arterial embolization with emulsions of lipiodol and sorafenib or with only lipiodol, while group Ⅲ was given hepatic arterial infusion with sorafenib. Sorafenib concentration in plasma was determined by HPLC (high performance liquid chromatography) in 0 min, 20 min, 1h, 2h, 4h, 8h, 16h, 32h and 48h respectively. The breathing rate, heart rate, rectal temperature and body weight were measured, as well the blood routine test and the function of liver, kidney, and heart. Two animals of each group were respectively killed in the 3rd day, 1st, 3rd and 6th week after treatment. Histopathologic study was done to liver, heart, kinney, lung, brain, gall bladder and intestine. Result: ① The peak sorafenib concentration (Cmax)and AUC(Area under curve) in plasma in groupⅠwas 2.46±0.101μg/ml and 945.72 ± 52.3 μg/mL.min respectively, while in group Ⅲ which was 3.78±0.180 ug/ml and 546.98±21.1μg/mL.min. Compared with groupⅢ, the Cmax and AUC of groupⅠhad a significant statistics difference (p<0.05). ② The breathing rate, heart rate, rectal temperature and AST/ALT,WBC,NEU% of group Ⅰand groupⅢhas a significant statistics difference(p<0.05) in the 3rd day. ③CK ,CK-MB, DB, Cr，BUN,RBC,PLT in plasma did not change in all group.④Local necrosis was seen in group Ⅰand group Ⅱin the 3rd day and 1st week, but they did not seem to be different. Group Ⅲ showed no necrosis. Granulation tissue with bile duty, portal vein and microfossils hyperplasia were seen in local necrosis area in the 3rd week. No pathological changes were found in brain, heart, kidney, intestine and gallbladder. Conclusion: TAE with emulsions of lipiodol and sorafenib is feasible, safe and has some slow-release effect.

Normal liver tissue change after proton beam therapy

2018 ◽  
Vol 36 (9) ◽  
pp. 559-565 ◽  
Author(s):  
Nobuyoshi Fukumitsu ◽  
Shinsei Takahashi ◽  
Toshiyuki Okumura ◽  
Toshiki Ishida ◽  
Keiko Nemoto Murofushi ◽  
...  
Keyword(s):  
Proton Beam ◽  
Liver Tissue ◽  
Normal Liver ◽  
Proton Beam Therapy ◽  
Normal Liver Tissue ◽  
Tissue Change

Caffeine does not enhance radiosensitivity of normal liver tissue in vivo

2010 ◽  
Vol 38 (7) ◽  
pp. 4359-4367 ◽  
Author(s):  
Tie-Jun Wang ◽  
Zhong-Shan Liu ◽  
Zhao-Chong Zeng ◽  
Shi-Suo Du ◽  
Ming Qiang ◽  
...  
Keyword(s):  
Liver Tissue ◽  
Normal Liver ◽  
Normal Liver Tissue

Accuracy of real-time shear wave elastography in the assessment of normal liver tissue in the guinea pig (cavia porcellus)

2017 ◽  
Vol 20 (1) ◽  
pp. 51-56
Author(s):  
K. Glińska-Suchocka ◽  
K. Kubiak ◽  
J. Spużak ◽  
M. Jankowski ◽  
P. Borusewicz
Keyword(s):  
Guinea Pig ◽  
Real Time ◽  
Shear Wave ◽  
Liver Tissue ◽  
Ultrasound Image ◽  
Shear Wave Elastography ◽  
Normal Liver ◽  
Normal Liver Tissue ◽  
Invasive Technique ◽  
Non Invasive

Abstract Shear wave elastography is a novel technique enabling real-time measurement of the elasticity of liver tissue. The color map is superimposed on the classic ultrasound image of the assessed tissue, which enables a precise evaluation of the stiffness of the liver tissue. The aim of the study was to assess the stiffness of normal liver tissue in the guinea pig using shear wave elastography. The study was carried out on 36 guinea pigs using the SuperSonic Imagine Aixplorer scanner, and a 1 to 6 MH convex SC6-1 transducer. An ultrasound guided Try-Cut liver core needle biopsy was carried out in all the studied animals and the collected samples were examined to exclude pathological lesions. The mean liver tissue stiffness ranged from 0.89 to 5.40 kPa. We found that shear wave elastography is an easy, non-invasive technique that can be used to assess the stiffness of liver tissue. The obtained results can be used in future studies to assess the types and changes of liver tissue in the course of various types of liver disease.

Caffeine Biotransformation in Human Hepatocyte Lines Derived from Normal Liver Tissue

1994 ◽  
Vol 201 (2) ◽  
pp. 559-566 ◽  
Author(s):  
E.A. Roberts ◽  
K.N. Furuya ◽  
B.K. Tang ◽  
W. Kalow
Keyword(s):  
Liver Tissue ◽  
Normal Liver ◽  
Human Hepatocyte ◽  
Normal Liver Tissue

scholarly journals Hepatostat: Liver regeneration and normal liver tissue maintenance

Hepatology ◽  
2017 ◽  
Vol 65 (4) ◽  
pp. 1384-1392 ◽  
Author(s):  
George K. Michalopoulos
Keyword(s):  
Liver Regeneration ◽  
Liver Tissue ◽  
Normal Liver ◽  
Normal Liver Tissue

Signal Suppression of Normal Liver Tissue by Phase Corrected Inversion Recovery

1989 ◽  
Vol 13 (4) ◽  
pp. 650-655 ◽  
Author(s):  
Bernt Lehmann ◽  
Ezio Fanucci ◽  
Francesco Gigli ◽  
Detlev Uhlenbrock ◽  
Carlo Bartolozzi
Keyword(s):  
Liver Tissue ◽  
Normal Liver ◽  
Inversion Recovery ◽  
Normal Liver Tissue ◽  
Signal Suppression

scholarly journals IR Bagendit Paddy Leaves Extract Improves Liver Cell Morphology and Reduces The Activity of Transaminase Enzymes After Lead Exposure in Rat

2020 ◽  
Vol 12 (3) ◽  
pp. 227-32
Author(s):  
Budi Santosa ◽  
Henna Ria Sunoko ◽  
Andri Sukeksi ◽  
Siti Thomas Zulaikhah
Keyword(s):  
Body Weight ◽  
Normal Liver ◽  
Hepatoprotective Activity ◽  
Liver Cells ◽  
The Body ◽  
Function Parameter ◽  
Control Group ◽  
Toxic Agent ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Treatment Groups

BACKGROUND: Lead (Pb) was known as one of systemic toxic agent. In the body, lead may be deactivated by the metallothioneins. Paddy leaves contain metallothioneins, sugars and pythosterols, and studies have shown the pharmacological activity of rice leaves on the protective effect of lead-induced rats against kidney function. The aim of this study was to evaluate the role of IR Bagendit paddy leaves extract as hepatoprotective agent.METHODS: Twenty-eight rats were divided into four groups: one control and three treatment groups. Control and treatment groups were exposed to lead of 0.5 g/kg body weight (BW)/day and then the treatment groups were administered with paddy leaves extract of 0.2; 0.4; and 0.8 g/kg BW/day per oral for 8 weeks. On the last day of the 8th week, body weight was measured and the numbers of normal, degenerative and necrotic liver cells were examined with hematoxylin-eosin staining. Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were measured as liver function parameter. Difference of variables between control and treatment groups were examined by Friedman test.RESULTS: There was no association in different BW between groups. The normal liver cells are higher in treatment than control group (p<0.001) and necrotic liver cells are lower in treatment than control group (p≤0.001). There was no association in degenerative liver cells between groups (p=0.153). The activity of transaminase enzymes are lower in treatment than control group (p<0.001).CONCLUSION: IR Bagendit Paddy leaves extract reveals hepatoprotective activity by improving liver cells morphology and reducing the activity of transaminase enzymes after lead exposure.KEYWORDS: paddy leaves extract, liver normal cell, necrotic cell, transaminase enzymes

Sign in / Sign up

Export Citation Format

Share Document