scholarly journals THE IMMUNOLOGICAL RELATIONSHIP OF THE CAPSULAR POLYSACCHARIDE OF TYPE XIV PNEUMOCOCCUS TO THE BLOOD GROUP A SPECIFIC SUBSTANCE

1939 ◽  
Vol 70 (3) ◽  
pp. 239-247 ◽  
Author(s):  
Paul B. Beeson ◽  
Walther F. Goebel
Keyword(s):  
Blood Group ◽  
Capsular Polysaccharide ◽  
Horse Serum ◽  
Human Erythrocytes ◽  
Blood Group A ◽  
Marked Diminution ◽  
Specific Substance ◽  
Group A ◽  
Immunological Relationship ◽  
Relationship Of

1. The agglutination of human erythrocytes and the precipitation of the blood group A substance by Type XIV antipneumococcus horse serum are properties of the specific anticarbohydrate immune bodies in the serum. 2. Absorption of Type XIV antipneumococcus horse serum with the homologous bacterial polysaccharide removes the agglutinins for human erythrocytes as well as the precipitins for the group A substance. 3. Absorption of Type XIV antipneumococcus horse serum with the group A substance markedly diminishes the ability of the serum to agglutinate erythrocytes of all groups. 4. Absorption of Type XIV antipneumococcus horse serum with human erythrocytes causes a marked diminution in the precipitation with group A substance. 5. The chemical and immunological relationship between the specific substances of blood group A and the Type XIV Pneumococcus is discussed.

scholarly journals IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS

1948 ◽  
Vol 87 (4) ◽  
pp. 295-300 ◽  
Author(s):  
Elvin A. Kabat ◽  
Aaron Bendich ◽  
Ada E. Bezer ◽  
Vesta Knaub
Keyword(s):  
Blood Group ◽  
Horse Serum ◽  
Blood Groups ◽  
Human Erythrocytes ◽  
Blood Group A ◽  
Group A

Purified blood group A, B, and O substances from hog and human sources precipitate with Type XIV antipneumococcal horse serum and provide an explanation for the observation that Type XIV antibody agglutinates human erythrocytes of all four major blood groups. Individual preparations of A substance or O substance from either species vary in their capacity to precipitate Type XIV antibody although the hog A substances did not differ in potency toward anti-A. Similarly, no correlation between A activity and reactivity with Type XIV antibody could be found among the human A substances.

scholarly journals THE ISOLATION OF THE BLOOD GROUP A SPECIFIC SUBSTANCE FROM COMMERCIAL PEPTONE

1938 ◽  
Vol 68 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Walther F. Goebel
Keyword(s):  
Blood Group ◽  
Blood Group A ◽  
Specific Substance ◽  
Group A

The isolation of the blood group A specific substance from commercial peptone has been described. The chemical and serological properties of the material from that source have been defined.

scholarly journals THE ISOLATION OF THE BLOOD GROUP A SPECIFIC SUBSTANCE FROM COMMERCIAL PEPTONE

1938 ◽  
Vol 68 (4) ◽  
pp. 640-640
Author(s):  
Walther F. Goebel
Keyword(s):  
Blood Group ◽  
Blood Group A ◽  
Specific Substance ◽  
Group A

Page 223, Table I, last column, 2nd line under per cent, for 7.07 read 70.7.

scholarly journals IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS

1948 ◽  
Vol 88 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Elvin A. Kabat ◽  
Harold Baer ◽  
Ada E. Bezer ◽  
Vesta Knaub
Keyword(s):  
Blood Group ◽  
Horse Serum ◽  
Cross Reactivity ◽  
Reducing Sugar ◽  
Polymeric Form ◽  
Blood Group A ◽  
Group A ◽  
Blood Group Substances ◽  
Hydrolysis Of ◽  
Paper Chromatographic Separation

1. The effect of heating at varying pH on the cross-reactivity of hog blood group A and 0 substances with Type XIV antibody has been investigated. The hydrolysis of blood group A, B, and O substances from hog and human sources at pH 1.5–1.8 resulted in destruction of blood group activity and a marked increase in cross-reactivity with Type XIV antipneumococcus horse serum. 2. Analysis revealed the liberation of reducing sugar, most of which was dialyzable. It was further shown that the major part of the reducing sugar was fucose with small amounts of free and polymerized galactose and glucosamine. Non-glucosamine nitrogen, probably amino acids, also was found in the dialysate. 3. Paper chromatographic separation of the concentrated dialysate confirmed the presence of fucose and showed that the majority of the galactose and glucosamine occurred in polymeric form. 4. Quantitative analysis of the substances isolated from the paper showed good recovery of the various components, indicating that practically all of the material in the dialysate could be accounted for. 5. The methylpentose of human blood group A substance was identified as fucose. 6. The structure of the blood group substances is interpreted in terms of these results.

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