scholarly journals SUSCEPTIBILITY OF RABBITS TO INFECTION BY THE INHALATION OF TYPE II PNEUMOCOCCI

1930 ◽  
Vol 52 (2) ◽  
pp. 215-224 ◽  
Author(s):  
Ernest G. Stillman
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Type Ii ◽  
Direct Proportion ◽  
Virulent Type ◽  
Fatal Septicemia ◽  
Pneumococcus Type

1. The susceptibility of rabbits to inhalations of pneumococci varies in direct proportion to the virulence of the organism for rabbits. 2. When rabbits are exposed to a pneumococcus spray, irrespective of the virulence of the organism, the bacteria readily penetrate into the lower respiratory tract. 3. When rabbits are exposed to a spray of avirulent degenerated "R" form of pneumococcus, septicemia does not occur and pneumococci are seldom recovered from the liver, kidney or spleen. 4. When rabbits are exposed to a spray of slightly virulent Pneumococcus Type II (SAv) a non-fatal septicemia may occur and pneumococci may be recovered from the liver, kidney and spleen. 5. When rabbits are exposed to a spray of virulent Type II (Sv) pneumococci, septicemia may occur which in certain instances terminates fatally. Pneumococci may also be recovered from the liver, kidney and spleen.

scholarly journals SUSCEPTIBILITY OF RABBITS TO INFECTION BY THE INHALATION OF VIRULENT PNEUMOCOCCI

1926 ◽  
Vol 44 (5) ◽  
pp. 581-587 ◽  
Author(s):  
Ernest G. Stillman ◽  
Arnold Branch
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Type I ◽  
Kidney Liver ◽  
Fatal Septicemia

1. Rabbits are very susceptible to infection by inhalation of Type I pneumococci. 2. When rabbits are exposed to a pneumococcus spray the bacteria readily penetrate into the lower respiratory tract. The pneumococci which reach the periphery of the lungs as a result of this procedure usually disappear within a few hours but a generalized and fatal septicemia frequently later appears. Pneumococci may then be recovered from the periphery of the kidney, liver, and spleen. In the animals which die pleurisy and pericarditis are common but pneumonia does not occur. 3. Rabbits may recover from pneumococcus septicemia.

scholarly journals DEVELOPMENT OF AGGLUTININS AND PROTECTIVE ANTIBODIES IN RABBITS, AFTER INHALATION OF TYPE II PNEUMOCOCCI

1930 ◽  
Vol 52 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Ernest G. Stillman
Keyword(s):  
Specific Response ◽  
Type Ii ◽  
Direct Proportion ◽  
Specific Antibodies ◽  
Virulent Type ◽  
Protective Antibodies

1. Following repeated inhalations of the degenerated non-virulent "R" forms of Type II pneumococcus, no type specific antibodies can be demonstrated in the serum of rabbits. 2. Following repeated inhalations of slightly virulent Type II (SAv) pneumococci, only protective antibodies can be demonstrated in the serum of rabbits. 3. Following repeated inhalations of virulent Type II (Sv) pneumococci, agglutinins and protective antibodies can be demonstrated in the serum of rabbits. 4. Following repeated exposures of rabbits to inhalation of pneumococci, the type specific response, evidenced by type specific protective antibodies and agglutinins, varies in direct proportion to the virulence of the culture used.

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