TAK1ng control: TAK1 restrains NLRP3 activation

Journal of Experimental Medicine ◽

10.1084/jem.20180282 ◽

2018 ◽

Vol 215 (4) ◽

pp. 1007-1008 ◽

Cited By ~ 4

Author(s):

Matthew Stephen Mangan ◽

Eicke Latz

Keyword(s):

Drug Treatment ◽

Potential Function ◽

Anticancer Drug ◽

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Specific Loss ◽

Nlrp3 Inflammasome Activation ◽

Tnf Secretion

In this issue of JEM, Malireddi et al. (https://doi.org/10.1084/jem.20171922) demonstrate that macrophage-specific loss of TAK1 causes spontaneous NLRP3 inflammasome activation, driven by unregulated TNF secretion and signaling. This has implications for therapeutically targeting TAK1, enhancing its potential function as an anticancer drug treatment.

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248-LB: Deficiency of APPL1 in Macrophages Triggers Adipose Tissue Inflammation and Insulin Resistance by Potentiating NLRP3 Inflammasome Activation

Diabetes ◽

10.2337/db19-248-lb ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 248-LB ◽

Cited By ~ 1

Author(s):

KELVIN K.L. WU ◽

AIMIN XU ◽

KENNETH K. CHENG

Keyword(s):

Insulin Resistance ◽

Adipose Tissue ◽

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Adipose Tissue Inflammation ◽

Tissue Inflammation ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717980435.793471692 ◽

2013 ◽

Author(s):

Laurel Lenz ◽

Rebecca Schmidt

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718039111.793480657 ◽

2013 ◽

Author(s):

Douglas Green ◽

Jennifer Martinez

Keyword(s):

Fatty Acids ◽

Nlrp3 Inflammasome ◽

Metabolic Disorder ◽

Inflammasome Activation ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of 3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718184539.793519737 ◽

2016 ◽

Author(s):

Eicke Latz

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726362863.793559823 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Dextran Sulfate ◽

Dextran Sulfate Sodium ◽

Experimental Colitis ◽

Dimethyl Fumarate ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of Hemin and cobalt protoporphyrin inhibit NLRP3 inflammasome activation by enhancing autophagy: A novel mechanism of inflammasome regulation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726766143.793523875 ◽

2016 ◽

Author(s):

Mark A Williams

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation ◽

Cobalt Protoporphyrin

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Faculty Opinions recommendation of Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734279765.793559839 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734514948.793559815 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Trans Golgi Network ◽

Nlrp3 Inflammasome Activation ◽

Golgi Network

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Faculty Opinions recommendation of The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735165969.793559816 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Cysteine Cathepsins ◽

Nlrp3 Inflammasome Activation

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Carrageenan Triggers NLRP3 Inflammasome Activation and IL-1β Production by Macrophages

SSRN Electronic Journal ◽

10.2139/ssrn.3405570 ◽

2019 ◽

Author(s):

Alexandre H. Lopes ◽

Rangel L. Silva ◽

Miriam D. Fonseca ◽

Francisco I. Gomes ◽

Alexandre G. Maganin ◽

...

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

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