scholarly journals Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

2008 ◽  
Vol 205 (13) ◽  
pp. 2953-2957 ◽  
Author(s):  
Pierre Bougnères ◽  
Alain-Jacques Valleron
Keyword(s):  
Type 1 Diabetes ◽  
Early Onset ◽  
Type I Diabetes ◽  
Metabolic Changes ◽  
Data Driven ◽  
Metabolic Phenotype ◽  
Type I ◽  
Β Cell ◽  
New Era

A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.

scholarly journals Health related quality of life among children with Type I diabetes, Assiut city, Egypt

2017 ◽  
Vol 7 (10) ◽  
pp. 73 ◽  
Author(s):  
Marzoka A. Gadallah ◽  
Taghreed Abdul-Aziz M. Ismail ◽  
Naglaa Saad Abdel Aty
Keyword(s):  
Quality Of Life ◽  
Type 1 Diabetes ◽  
Health Insurance ◽  
Type I Diabetes ◽  
Type I ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Objective: Health related quality of life (HRQOL) is a multidimensional construct that includes physical and psychosocial functioning, has emerged as an important outcome in pediatric population with chronic health conditions. The study objectives are to measure the quality of life among children with type I diabetes compared to healthy peers and to determine factors affecting the QOL among children with type I diabetes.Methods: Analytic cross sectional study was conducted in Sidi Galal health insurance outpatient clinic for children with type 1 diabetes mellitus and a comparison group of healthy peers was taken from other outpatient clinics. A total of four hundred and twelve children, aged from 8-18 years with type 1 diabetes and four hundred and twelve healthy peers matched in age and sex were interviewed. Three tools were used for this study: Demographic questionnaire, Socio-economic scale, and Peds QL4.0 Generic Core Scale was used to measure HRQOL.Results: The mean age of studied children was 12.9 ± 3.2. More than 60% of children with diabetes had uncontrolled glycemic level and 60% of them were in low socio-economic level. Children with diabetes had significantly lower HRQOL than healthy children in all domains. Age, glycemic control status and birth order of the diabetic children showed no significance difference regarding the QOL. Disease duration affected only the emotional function of the QOL and females showed significantly higher score regarding school functioning. Social, school and the total QOL scores were significantly higher among children with highly educated mothers while father's education affected the emotional, school and total QOL scores. Children in the middle and high social class showed significantly higher scores regarding social, school and total QOL. Presence of diabetic parent positively affected the social functioning while had negative effect on the school function of children with type I diabetes.Conclusions and recommendations: Diabetes is negatively affecting all the QOL functioning of the children. We recommend that Integrated programs between child's home, school and health insurance clinics for educating and supporting children with diabetes to improve their HRQOL.

Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice

2016 ◽  
Vol 26 (1) ◽  
Author(s):  
Amira Alkharusi ◽  
Mercedes Mirecki-Garrido ◽  
Zuheng Ma ◽  
Fahad Zadjali ◽  
Amilcar Flores-Morales ◽  
...  
Keyword(s):  
Type I Diabetes ◽  
Janus Kinase ◽  
Cytokine Signaling ◽  
Type I ◽  
Suppressor Of Cytokine Signaling ◽  
Β Cell ◽  
Diabetes In Mice ◽  
Socs Proteins ◽  
Stat Pathway

AbstractDiabetes type 1 is characterized by the failure of beta cells to produce insulin. Suppressor of cytokine signaling (SOCS) proteins are important regulators of the Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway. Previous studies have shown that GH can prevent the development of type I diabetes in mice and that SOCS2 deficiency mimics a state of increased GH sensitivity.The elevated sensitivity of SOCS2We show that 6-month-old SOCS2Knockdown of SOCS2 makes mice less sensitive to MLDSTZ. These results are consistent with the proposal that elimination of SOCS2 in pancreatic islets creates a state of β-cell hypersensitivity to GH/PRL that mimics events in pregnancy, and which is protective against MLDSTZ-induced type I diabetes in mice. SOCS2-dependent control of β-cell survival may be of relevance to islet regeneration and survival in transplantation.

Functional defects in adenylyl cyclase signaling mechanisms of insulin and relaxin in skeletal muscles of rat with streptozotocin type 1 diabetes

2006 ◽  
Vol 1 (4) ◽  
pp. 530-544 ◽  
Author(s):  
Alexander Shpakov ◽  
Ludmila Kuznetsova ◽  
Svetlana Plesneva ◽  
Alexander Kolychev ◽  
Vera Bondareva ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Adenylyl Cyclase ◽  
Skeletal Muscles ◽  
Glycogen Synthase ◽  
Type I Diabetes ◽  
Functional Coupling ◽  
Type I ◽  
Stimulatory Action ◽  
Functional Disturbance

AbstractFunctional disturbance in the novel adenylyl cyclase signaling mechanism (ACSM) of insulin and relaxin action in rat streptozotocin (STZ) type I diabetes was studied on the basis of the authors’ conception of molecular defects in hormonal signaling systems as the main causes of endocrine diseases. Studying the functional state of molecular components of the ACSM and the mechanism as a whole, the following changes were found in the skeletal muscles of diabetic rats compared with control animals: 1) increase of insulin receptor binding due to an increase in the number of insulin binding sites with high and low affinity; 2) increase of the basal adenylyl cyclase (AC) activity and the reduction of AC-activating effect of non-hormonal agents (guanine nucleotides, sodium fluoride, forskolin); 3) reduction of ACSM response to stimulatory action of insulin and relaxin; 4) decrease of the insulin-activating effect on the key enzymes of carbohydrate metabolism, glycogen synthase and glucose-6-phosphate dehydrogenase. Hence, the functional activity of GTP-binding protein of stimulatory type, AC and their functional coupling are decreased during experimental type 1 diabetes that leads to the impairment of the transduction of insulin and relaxin signals via ACSM.

scholarly journals Increased Circulating T Follicular Helper Cells in Iranian Children with Type I Diabetes

2019 ◽  
Author(s):  
Mansour Arab ◽  
Maryam Razzaghy-azar ◽  
Zahra Salehi ◽  
Maryam Keshavarz ◽  
Ensieh Nasli-Esfahani ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autoimmune Disease ◽  
Type I Diabetes ◽  
Type I ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper ◽  
Iranian Children

Type 1 diabetes (T1D) is an autoimmune disease resulting from the damage of pancreatic

Kinetics of sodium-lithium countertransport activity in patients with uncomplicated type I diabetes

1992 ◽  
Vol 82 (3) ◽  
pp. 291-299 ◽  
Author(s):  
Peter A. Rutherford ◽  
Trevor H. Thomas ◽  
Susan J. Carr ◽  
Roy Taylor ◽  
Robert Wllklnson
Keyword(s):  
Type 1 Diabetes ◽  
Essential Hypertension ◽  
Type I Diabetes ◽  
Plasma Lipid ◽  
Maximum Velocity ◽  
Diabetic Patients ◽  
Type I ◽  
High Sodium ◽  
Type 1 Diabetic Patients

1. Increased erythrocyte sodium-lithium countertransport activity has been reported to be associated with nephropathy in type 1 diabetes and linked to a family history of essential hypertension. 2. This study aimed to determine the mechanism of increased sodium-lithium countertransport activity. Sodium-lithium countertransport kinetics were measured in uncomplicated and hyperlipidaemic type 1 diabetic patients. 3. In the nine out of 31 uncomplicated type 1 diabetic patients who had high sodium-lithium countertransport activity, the sodium affinity (Km) was normal but the maximum velocity (Vmax.) was increased. 4. Hyperlipidaemia, when present in diabetic patients, was associated with increased sodium-lithium countertransport activity, but could not explain the high activity in uncomplicated type 1 diabetic patients in whom plasma lipid concentrations were normal. 5. Sodium-lithium countertransport activity is increased in type 1 diabetes by a mechanism different to that in essential hypertension, where the mechanism is a low Km (increased sodium affinity). Hence familial hypertension cannot explain the raised sodium-lithium countertransport activity in type 1 diabetes.

scholarly journals Type I Diabetes Mellitus: Genetic Factors and Presumptive Enteroviral Etiology or Protection

2014 ◽  
Vol 2014 ◽  
pp. 1-21 ◽  
Author(s):  
Jana Precechtelova ◽  
Maria Borsanyiova ◽  
Sona Sarmirova ◽  
Shubhada Bopegamage
Keyword(s):  
Type 1 Diabetes ◽  
Inflammatory Diseases ◽  
Type I Diabetes ◽  
Oral Route ◽  
Basic Knowledge ◽  
Type I ◽  
Human Pathogens ◽  
Genetic Components ◽  
Chronic Myocarditis

We review type 1 diabetes and host genetic components, as well as epigenetics and viruses associated with type 1 diabetes, with added emphasis on the enteroviruses, which are often associated with triggering the disease. GenusEnterovirusis classified into twelve species of which seven (Enterovirus A, Enterovirus B, Enterovirus C,andEnterovirus DandRhinovirus A, Rhinovirus B,andRhinovirus C) are human pathogens. These viruses are transmitted mainly by the fecal-oral route; they may also spread via the nasopharyngeal route. Enterovirus infections are highly prevalent, but these infections are usually subclinical or cause a mild flu-like illness. However, infections caused by enteroviruses can sometimes be serious, with manifestations of meningoencephalitis, paralysis, myocarditis, and in neonates a fulminant sepsis-like syndrome. These viruses are often implicated in chronic (inflammatory) diseases as chronic myocarditis, chronic pancreatitis, and type 1 diabetes. In this review we discuss the currently suggested mechanisms involved in the viral induction of type 1 diabetes. We recapitulate current basic knowledge and definitions.

scholarly journals Correction of dyslipidemia with combined use of beta-sitosterol and polyprenyl phosphates in dogs with type 1 diabetes mellitus

2019 ◽  
Vol 2019 (5) ◽  
pp. 12-15
Author(s):  
Вячеслав Анников ◽  
Vyacheslav Annikov ◽  
Александр Наровлянский ◽  
Aleksandr Narovlyanskiy ◽  
Александр Санин ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Type I Diabetes ◽  
Control Group ◽  
Type I ◽  
Upper Limit ◽  
Combined Use ◽  
Polyprenyl Phosphates

This study considers the efficiency of use of a combined drug based on beta-sitosterol and polyprenyl phosphates in dogs with type I diabetes mellitus complicated by hyperlipidemia. It was shown that after 1 month of the therapy, there was a significant decrease of the level of cholesterol, triglycerides and glucose vs. control animals. After 2 months of the therapy, in the control group the level of cholesterol and triglycerides was at the upper limit of the norm, which can lead to an exacerbation of the disease in future.

scholarly journals Thyroid auto immune antibodies in children with Type-I Diabetes mellitus in relation to diabetes control

2019 ◽  
Vol 35 (4) ◽  
Author(s):  
Muneera Fadhil Ridha ◽  
Munib Ahmed Al Zubaidi
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type I Diabetes ◽  
Thyroid Autoimmunity ◽  
Diabetic Control ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Thyroid Antibodies

Background & Objective: As an autoimmune disease, Type-1 diabetes mellitus (DM) may be associated with other autoimmune disorders, the presence of thyroid antibodies could be negatively impact the diabetic control. Our objective was to investigate thyroid autoimmunity in a cohort of children and adolescents with Type-1 diabetes and the Influence of the presence of thyroid autoimmune abnormalities on the control of diabetes in group of Iraqi pediatric patients with Type-I D.M. Methods: This study was conducted at the Medical City Complex, Children Welfare Hospital, Baghdad, Iraq. This study was carried out from the first of January 2016 till the end of September 2017. Data were analyzed from 150 patients with Type-1 diabetes, aged 1–18 years who were treated and are coming for regular follow up in the diabetic clinic. Thyroid functions tests, Antibodies to thyroglobulin (anti-TG) and thyroperoxidase (anti-TPO) were measured, documented and correlated with diabetic control according to glycated haemoglobin (HbA1c) level. Results: In the total of 150 patients, positive Antibodies to thyroglobulin (anti TG) were more in ≤3 years duration group of Diabetes mellitus( DM) and negative anti TG was less in the >3 years duration of DM group with statistically significant results (p=0.043), Regarding the distribution of thyroid antibodies (AB) according to HbA1c group, there was progressive positive anti thyroperoxidase (anti TPO) titer with glycemic status, good glycemic control had the lowest positive anti TPO titer and poor glycemic control group had the highest positive anti TPO titer and the result was statistically significant (p=0.048). Conclusions: Thyroid autoimmunity may be associated with poor diabetic control and elevated TSH levels, indicating subclinical hypothyroidism that my affect the diabetic control. doi: https://doi.org/10.12669/pjms.35.4.192 How to cite this:Ridha MF, Al-Zubaidi MA. Thyroid auto immune antibodies in children with type I Diabetes mellitus in relation to diabetes control. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.192 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals HLA-Dependent TNF Secretory Response May Provide an Immunogenetic Link between Pre-Eclampsia and Type 1 Diabetes Mellitus

1996 ◽  
Vol 13 (1) ◽  
pp. 43-47 ◽  
Author(s):  
David C. Kilpatrick
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Tumour Necrosis ◽  
Type I Diabetes ◽  
Type I ◽  
Weak Association ◽  
Hla Dr ◽  
Population Controls ◽  
Necrosis Factor

Tumour necrosis factor (TNF) may be relevant to the pathogenesis of both pre-eclampsia and type I diabetes, and there is evidence than human TNFα responses to stimuli are HLA-DR dependent. To test the hypothesis that pre-eclampsia and diabetes may share a common immunogenetic susceptibility, 92 pre-eclampsia patients were compared with 264 general population controls. The relative frequencies of individual HLA-DR antigens in pre-eclamptics were found to correlate with reported relative TNFα responses for those antigens. Moreover, putative high responder HLA-DR I, DR3 and DR4 alleles were significantly (p<0.00 I) more frequent in pre-eclampsia patients (79%) than in controls (59%). This hypothesis could explain the weak association between pre-eclampsia and diabetes and may help resolve the apparently conflicting literature on HLA in pre-eclampsia.

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