scholarly journals Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti–Salmonella typhimurium immunity

2008 ◽  
Vol 205 (3) ◽  
pp. 657-667 ◽  
Author(s):  
Gianluca Rotta ◽  
Gianluca Matteoli ◽  
Elisa Mazzini ◽  
Paolo Nuciforo ◽  
Mario P. Colombo ◽  
...  
Keyword(s):  
Immune Response ◽  
Salmonella Typhimurium ◽  
Adaptive Immune Response ◽  
Matricellular Protein ◽  
Matricellular Proteins ◽  
Inflammatory Reactions ◽  
Adaptive Immune ◽  
Draining Lymph Nodes ◽  
Increased Susceptibility

The role of matricellular proteins in bacterial containment and in the induction of pathogen-specific adaptive immune responses is unknown. We studied the function of the matricellular protein secreted protein, acidic and rich in cysteine (SPARC/osteonectin) in the dissemination of locally injected Salmonella typhimurium and in the subsequent immune response. We show that SPARC was required for the development of organized acute inflammatory reactions with granuloma-like (GL) features and for the control of bacterial spreading to draining lymph nodes (DLNs). However, SPARC-related GL also inhibited dendritic cell (DC) migration to the DLNs and limited the development of adaptive immune response, thus conferring increased susceptibility to the pathogen. In SPARC-deficient mice, both DC migration and antigen-specific responses were restored against bacteria, leading to protective anti–S. typhimurium immunity. This highlights a new function of matricellular proteins in bacterial infection and suggests that initial containment of bacteria can have drawbacks.

scholarly journals Vitamin D in Early Childhood and the Effect on Immunity toMycobacterium tuberculosis

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Anna Jane Battersby ◽  
Beate Kampmann ◽  
Sarah Burl
Keyword(s):  
Vitamin D ◽  
Immune Response ◽  
Pattern Recognition ◽  
Early Childhood ◽  
Potential Role ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Increased Susceptibility ◽  
Stimulation Of

A potential role for vitamin D as a therapeutic immunomodulator in tuberculosis (TB) has been recognised for over 150 years, but has only recently returned to the centre of the research arena due to the increasing awareness of the global vitamin D deficiency epidemic. As early as birth a child is often deficient in vitamin D, which may not only affect their bone metabolism but also modulate their immune function, contributing to the increased susceptibility to many infections seen early in life. Recent studies have begun to explain the mechanisms by which vitamin D affects immunity. Antimicrobial peptides are induced in conjunction with stimulation of innate pattern recognition receptors enhancing immunity to particular infections. In contrast the role of vitamin D within the adaptive immune response appears to be more regulatory in function, perhaps as a mechanism to reduce unwanted inflammation. In this paper we focus on the effect of vitamin D on immunity to TB. Where much of the attention has been paid by past reviews to the role of vitamin D in adult TB patients, this paper, where possible, focuses on research in paediatric populations.

scholarly journals Pattern Recognition Proteins: First Line of Defense Against Coronaviruses

2021 ◽  
Vol 12 ◽  
Author(s):  
Carlos A. Labarrere ◽  
Ghassan S. Kassab
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Global Economy ◽  
Rna Viruses ◽  
Severe Disease ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Recognition Protein ◽  
Pattern Recognition Protein

The rapid outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 in Wuhan, China, has become a worldwide pandemic affecting almost 204 million people and causing more than 4.3 million deaths as of August 11 2021. This pandemic has placed a substantial burden on the global healthcare system and the global economy. Availability of novel prophylactic and therapeutic approaches are crucially needed to prevent development of severe disease leading to major complications both acutely and chronically. The success in fighting this virus results from three main achievements: (a) Direct killing of the SARS-CoV-2 virus; (b) Development of a specific vaccine, and (c) Enhancement of the host’s immune system. A fundamental necessity to win the battle against the virus involves a better understanding of the host’s innate and adaptive immune response to the virus. Although the role of the adaptive immune response is directly involved in the generation of a vaccine, the role of innate immunity on RNA viruses in general, and coronaviruses in particular, is mostly unknown. In this review, we will consider the structure of RNA viruses, mainly coronaviruses, and their capacity to affect the lungs and the cardiovascular system. We will also consider the effects of the pattern recognition protein (PRP) trident composed by (a) Surfactant proteins A and D, mannose-binding lectin (MBL) and complement component 1q (C1q), (b) C-reactive protein, and (c) Innate and adaptive IgM antibodies, upon clearance of viral particles and apoptotic cells in lungs and atherosclerotic lesions. We emphasize on the role of pattern recognition protein immune therapies as a combination treatment to prevent development of severe respiratory syndrome and to reduce pulmonary and cardiovascular complications in patients with SARS-CoV-2 and summarize the need of a combined therapeutic approach that takes into account all aspects of immunity against SARS-CoV-2 virus and COVID-19 disease to allow mankind to beat this pandemic killer.

Antigenic role of the adaptive immune response to d -ribose glycated LDL in diabetes, atherosclerosis and diabetes atherosclerotic patients

Life Sciences ◽  
2016 ◽  
Vol 151 ◽  
pp. 139-146 ◽  
Author(s):  
Firoz Akhter ◽  
M. Salman Khan ◽  
Abdulrahman A. Alatar ◽  
Mohammad Faisal ◽  
Saheem Ahmad
Keyword(s):  
Immune Response ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Glycated Ldl

scholarly journals Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson's disease

Glia ◽  
2015 ◽  
Vol 64 (3) ◽  
pp. 386-395 ◽  
Author(s):  
Heather L. Martin ◽  
Matteo Santoro ◽  
Sarah Mustafa ◽  
Gernot Riedel ◽  
John V. Forrester ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Immune Response ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Adaptive Immune Response ◽  
Disease Pathogenesis ◽  
Adaptive Immune

scholarly journals The Role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in Regulating the Innate and Adaptive Immune Response

2013 ◽  
Vol 69 (4) ◽  
pp. 383-394 ◽  
Author(s):  
Fernando F. Martinez ◽  
Laura Cervi ◽  
Carolina P. Knubel ◽  
Graciela M. Panzetta-Dutari ◽  
Claudia C. Motran
Keyword(s):  
Immune Response ◽  
Adaptive Immune Response ◽  
Adaptive Immune
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