scholarly journals AN EXPERIMENTAL STUDY OF THE LATE GLOMERULAR LESIONS CAUSED BY CROTALUS VENOM

1913 ◽  
Vol 18 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Richard M. Pearce
Keyword(s):  
Experimental Study ◽  
The Other ◽  
Chronic Glomerulonephritis ◽  
Experimental Demonstration ◽  
Glomerular Lesion ◽  
Glomerular Nephritis ◽  
Glomerular Lesions ◽  
Hemorrhagic Lesion ◽  
Mode Of Development ◽  
Glomerular Tuft

The acute exudative glomerular lesion of the rabbit's kidney caused by crotalus venom does not lead to a subacute or chronic glomerulonephritis. The hemorrhagic lesion of the glomerular tuft may show a process of repair characterized by the ingrowth, into the hemorrhagic masses, of endothelial cells from the uninjured part of the tuft. This process is, however, more analogous to the organization of a red thrombus than it is to any form of glomerular lesion known in man, and can hardly serve as an experimental demonstration of the mode of development of a subacute or chronic glomerular nephritis. On the other hand, crotalus venom causes a persistent albuminuria and extensive tubular degeneration and cast formation, with death, preceded by great emaciation, after five to six weeks.

scholarly journals AN EXPERIMENTAL GLOMERULAR LESION CAUSED BY VENOM (CROTALUS ADAMANTEUS)

1909 ◽  
Vol 11 (4) ◽  
pp. 532-540 ◽  
Author(s):  
Richard M. Pearce
Keyword(s):  
The Body ◽  
The Other ◽  
Tubular Injury ◽  
Histological Changes ◽  
Glomerular Lesion ◽  
Selective Action ◽  
Other Hand ◽  
Hemorrhagic Lesion ◽  
Glomerular Tuft

The venom of Crotalus adamanteus when administered intravenously to rabbits in properly graded doses causes lesions of the glomerulus of tile kidney which may be either hemorrhagic or exudative in character. Both types of lesion are usually associated but either one or the other may predominate. The hemorrhagic lesion, which may be confined to the glomerular tuft, or, by rupture of the latter, may involve the capsular space, is a peculiar localization of the hemorrhage so common in other parts of the body in venom intoxication. On the other hand, the exquisite exudative lesion involving usually the capsular space but sometimes limited, as in the hemorrhagic type, to the tuft itself and with little or no tubular injury, constitutes a type of experimental vascular nephritis, hitherto undescribed, which differs widely in its anatomical appearance from that due to arsenic, cantharidin and other vascular poisons. As the limitation of the lesion to the glomerulus indicates a selective action of the venom, and as the histological changes in the tuft are suggestive of gradual endothelial destruction and solution, the lesion can be explained by the action of the endotheliolytic body of crotalus venom described by Flexner and Noguchi.

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

Further Problems in the Interpretation and Homology of the Insect Ovipositor

1964 ◽  
Vol 96 (1-2) ◽  
pp. 405-417 ◽  
Author(s):  
G. G. E. Scudder
Keyword(s):  
Experimental Study ◽  
Normal Development ◽  
Organ Formation ◽  
Larval Stages ◽  
Insect Phylogeny ◽  
Correct Form ◽  
Developmental Capacity ◽  
Mode Of Development ◽  
Dual Origin

AbstractAn attempt is made to re-evaluate the data on the origin of the ovipositor in insects and to explain its mode of development in living forms. Comparative developmental data from other groups of animals is cited to substantiate the claim that part of the insect ectodermal genitalia is appendicular rather than sternal in origin. It is suggested that the primary abdominal segmental appendages have provided a source of competent tissue which through subtle changes in selection, has evolved along many pathways, to form the gonocoxae, the pleuropodia, the pseudoplacenta and perhaps the prolegs in many different taxa.It is shown, by aid of sections through the insect embryo and larval stages, that the primary embryonic segmental appendages on the abdomen, do not differentiate; there is no loss of tissue and it cannot be proven that such appendages have been lost in insect phylogeny. The fact that they are represented still in the modern embryo, indicates that they have been retained. To explain the observable developmental details, it is suggested that abdominal limb histogenesis is arrested or suppressed in normal development, but this limb tissue retains its competence to differentiate. Thus development may be initiated again at a later time in postembryonic life. In this manner, the original limb tissue is available for organ formation in the maturing insect.The study has suggested that the appendages on the eighth and ninth segments of the abdomen initiate but do not complete their development in the polypod embryo. Possibly the potential limb tissue is arrested in development because it has not undergone some vital change as regards its capacity to respond (competence) to an inductor, perhaps the inductor is not available or perhaps it is not available in the correct form.There is evidence to suggest that the developmental capacity of the limb anlagen are reduced with time, so that full limb formation is not possible in postembryonic life: this can explain the development of abdominal coxae in the Thysanura and hence gonocoxae in higher insects. It is noted that should Gustafson's suggestion that the eversible sacs and gonapophyses are homologous with primary segmental genitalic ampullae prove acceptable, then the female ectodermal genitalia in insects would appear to have a dual origin.It is emphasized that the speculation expressed are being subjected to experimental study in an attempt to verify the suggested ontogeny and phylogeny.

Effectiveness of Virtual Resilience Training on Assertiveness in Student Girls Aged 9–10 Years: A 1-Month Follow-Up

2021 ◽  
pp. 105984052110135
Author(s):  
Shima Gadari ◽  
Jamile Farokhzadian ◽  
Parvin Mangolian Shahrbabaki
Keyword(s):  
Experimental Study ◽  
Internal Stress ◽  
Intervention Group ◽  
The Other ◽  
Hormonal Changes ◽  
Emotional Instability ◽  
Other Hand ◽  
Significant Difference ◽  
Resilience Training

Girls between the ages of 9 and 10 begin to experience physical, physiological, and hormonal changes that may lead to internal stress. At this age, children are struggling for autonomy; on the other hand, they may experience emotional instability, and for these reasons, they may be vulnerable in many ways. This experimental study aimed to investigate the effect of resilience training on assertiveness in student girls aged 9–10. Data were collected before, immediately after, and 1 month after the intervention in the control ( n = 40) and intervention ( n = 37) groups. There was a significant difference between the assertiveness of the intervention immediately (26.80 ± 3.73) and 1 month after the intervention (27.05 ± 3.73), and assertiveness significantly increased in the intervention group ( p = .0001). Resilience training leads to improvements in assertiveness in student girls aged 9–10.

Study of wave attenuation in concrete

1993 ◽  
Vol 8 (9) ◽  
pp. 2344-2353 ◽  
Author(s):  
J-M. Berthelot ◽  
Souda M. Ben ◽  
J.L. Robert
Keyword(s):  
Experimental Study ◽  
Plane Wave ◽  
Wave Attenuation ◽  
Plane Waves ◽  
Propagation Distance ◽  
Experimental Results ◽  
The Other ◽  
Wave Frequency ◽  
Concrete Composition ◽  
Analytical Expression

The experimental study of wave attenuation in concrete has been achieved in the case of the propagation of plane waves in concrete rods. Different mortars and concretes have been investigated. A transmitter transducer coupled to one of the ends of the concrete rod generates the propagation of a plane wave in the rod. The receiver transducer, similar to the previous one, is coupled to the other end of the rod. The experimental results lead to an analytical expression for wave attenuation as function of the concrete composition, the propagation distance, and the wave frequency.

Experimental Study on Racetrack-Shaped Holes Impingement Cooling With Bump Type Roughening Element

2012 ◽  
Author(s):  
Chiyuki Nakamata ◽  
Yoji Okita ◽  
Takashi Yamane ◽  
Yoshitaka Fukuyama ◽  
Toyoaki Yoshida
Keyword(s):  
Experimental Study ◽  
Flow Condition ◽  
Reynolds Numbers ◽  
Main Flow ◽  
The Other ◽  
Relative Location ◽  
Target Plate ◽  
Cooling Effectiveness ◽  
Impingement Cooling ◽  
Cooling Air

Cooling effectiveness of an impingement cooling with array of racetrack-shaped impingement holes is investigated. Two types of specimens are investigated. One is a plain target plate and the other is a plate roughened with bump type elements. Sensitivity of relative location of bump to impingement hole on the cooling effectiveness is also investigated. Experiments are conducted under three different mainflow Reynolds numbers ranging from 2.6×105 to 4.7×105, with four different cooling air Reynolds numbers for each main flow condition. The cooling air Reynolds numbers are in the range from 1.2×103 to 1.3×104.

Tribological Study of Polymer Composite Forming Using Model Experiments and Real Composites

2014 ◽  
Vol 611-612 ◽  
pp. 300-305 ◽  
Author(s):  
Olga Smerdova ◽  
Michael P.F. Sutcliffe
Keyword(s):  
Experimental Study ◽  
Polymer Composites ◽  
Viscous Liquid ◽  
Polymer Composite ◽  
Contact Area ◽  
Essential Feature ◽  
The Other ◽  
Carbon Fabric ◽  
Simultaneous Application ◽  
Composite Forming

This experimental study is focused on identification of tribological mechanisms acting during forming of polymer composites. The range of relevant processes includes fibre placement, tape lay-up, moulding, draping, and RTM. Two types of tribological experiments, relying both on simultaneous application of compression and shear loadings, are carried out. Firstly, model macromechanical tests are undertaken on plastic rods of millimetric diameter immersed in a viscous liquid, representing composite fibres and matrix, respectively. By careful simulation of forming conditions, this experiment helps to identify the friction phenomena occurring in real composites. On the other hand, the micromechanics of forming processes is studied through a microscopic experiment on real carbon fabric. This material is clamped between two glass plates and pulled in opposing directions in the plane of the fabric. It is hypothesized that the evolution of contact area due to shearing that can be measured in this experiment is an essential feature of the tribology of forming processes, a topic which hitherto has not been investigated.

The Mindfulness-Based Stress Reduction Program (MBSR) Reduces Stress-Related Psychological Distress in Healthcare Professionals

2010 ◽  
Vol 13 (2) ◽  
pp. 897-905 ◽  
Author(s):  
Andrés Martín-Asuero ◽  
Gloria García-Banda
Keyword(s):  
Experimental Study ◽  
Psychological Distress ◽  
Stress Reduction ◽  
Health Professionals ◽  
Healthcare Professionals ◽  
Training Programs ◽  
The Other ◽  
Reduction Program ◽  
Mindfulness Based Stress Reduction

This semi-experimental study examines how Mindfulness facilitates a distress reduction in a group of health professionals. The sample comprises 29 professionals seeking stress reduction who undertook an 8 weeks psico-educative intervention, involving 28 hours of class, based on a program called Mindfulness-based Stress Reduction or MBSR. Results show a 35% reduction of distress, from percentile 75 to 45, combined with a 30% reduction in rumination and a 20% decrease in negative affect. These benefits lasted during the 3 months of the follow up period. The correlation analysis indicates that the decrease in distress is significantly related to the other two variables. These results confirm the effectiveness of MBSR to decrease distress and its applicability in training programs for health professionals.

scholarly journals Glomerulonephritis in schistosomiasis with mesangial IgM deposits

1981 ◽  
Vol 76 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Ageu Godoy Magalhães Filho ◽  
Antônio Victoriano Barbosa ◽  
Teresa Cristina Ferreira
Keyword(s):  
Cell Proliferation ◽  
Light Microscopy ◽  
Immunofluorescence Microscopy ◽  
The Other ◽  
Proliferative Glomerulonephritis ◽  
Mesangial Proliferative Glomerulonephritis ◽  
Normal Pattern ◽  
Glomerular Lesions ◽  
Capillary Walls ◽  
Igm Deposits

Twenty one cases of hepatoesplenic schistosomiasis patients without clinical and laboratory evidence of renal disease, were studied by surgical biopsies using light microscopy and immunofluorescence. The cases were classified histologically as: normal pattern (6 cases); minimal changes (6 cases); and mesangial proliferative glomerulonephritis (9 cases). By the immunofluorescence microscopy using anti IgM, IgG, IgA and C3, the predominant finding in all biopsies, except the normal cases, was granular deposits of IgM in the mesangium along with C3. On the other hand, IgG was present in all cases including normal biopsies along the capillary walls. However IgG was also present in the mesangium only in cases with glomerular lesions. This finding may well be similar to that recently described as IgM mesangial nephropathy. According to our cases a mesangial proliferative glomerulonephritis, characterized by segmental cell proliferation and deposition of IgM in the mesangium, is probably the entity found in the early stages of mansonic schistosomiasis.

scholarly journals Modified method for bronchial suture by Ramirez Gama compared to separate stitches suture: experimental study

2014 ◽  
Vol 41 (3) ◽  
pp. 188-192
Author(s):  
Vitor Mayer de Moura ◽  
Erinaldo Rocha Paes Lamdim ◽  
Felipe Souza Ferraz ◽  
Rodrigo Carvalho Turatti ◽  
Carolina de Barros Jaqueta ◽  
...  
Keyword(s):  
Experimental Study ◽  
The Other ◽  
Compressed Air ◽  
Air Leak ◽  
Bronchial Stump ◽  
Modified Method ◽  
Tracheal Pressure ◽  
Air Ventilation ◽  
Manual Suture ◽  
Isolated Trachea

OBJECTIVE: To experimentally compare two classic techniques described for manual suture of the bronchial stump. METHODS: We used organs of pigs, with isolated trachea and lungs, preserved by refrigeration. We dissected 30 bronchi, which were divided into three groups of ten bronchi each, of 3mm, 5mm, and 7mm, respectively. In each, we performed the suture with simple, separated, extramucosal stitches in five other bronchi, and the technique proposed by Ramirez and modified by Santos et al in the other five. Once the sutures were finished, the anastomoses were tested using compressed air ventilation, applying an endotracheal pressure of 20mmHg. RESULTS: the Ramirez Gama suture was more effective in the bronchi of 3, 5 and 7 mm, and there was no air leak even after subjecting them to a tracheal pressure of 20mmHg. The simple interrupted sutures were less effective, with extravasation in six of the 15 tested bronchi, especially in the angles of the sutures. These figures were not significant (p = 0.08). CONCLUSION: manual sutures of the bronchial stumps were more effective when the modified Ramirez Gama suture was used in the caliber bronchi arms when tested with increased endotracheal pressure.

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