scholarly journals Genetically determined resistance to 3-methylcholanthrene-induced lymphoma is expressed at the level of bone marrow-derived cells.

1987 ◽  
Vol 166 (2) ◽  
pp. 565-570 ◽  
Author(s):  
S T Ishizaka ◽  
F Lilly
Keyword(s):  
Bone Marrow ◽  
Mouse Strains ◽  
Thymic Lymphoma ◽  
Bone Marrow Derived Cells ◽  
Genetically Determined

Reciprocal bone marrow transfers were performed between mouse strains sensitive or resistant to 3-methylcholanthrene-induced thymic lymphoma. Sensitivity and resistance are properties inherent in bone marrow, and cannot be altered by maturation of marrow in an environment of the opposite phenotype.

Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock

2005 ◽  
Vol 288 (2) ◽  
pp. H577-H583 ◽  
Author(s):  
Brian W. Binck ◽  
May F. Tsen ◽  
Miguel Islas ◽  
D. Jean White ◽  
Roger A. Schultz ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Ex Vivo ◽  
Myocardial Dysfunction ◽  
Endotoxic Shock ◽  
Left Ventricular ◽  
Mouse Strains ◽  
Contractile Dysfunction ◽  
Contractile Responses ◽  
Bone Marrow Derived Cells ◽  
Deficient Mice

How infection precipitates depressed contractility is incompletely understood but may involve the immune, nervous, and endocrine systems as well as the heart itself. In this study, we examined the role of Toll-like receptor 4 (TLR4) in LPS-induced myocardial contractile depression. Eighteen hours following endotoxin challenge, we compared contractile responses in hearts from wild-type (WT) and TLR4-deficient mice using modified Langendorff preparations. Unlike hearts from WT mice, TLR4-deficient hearts did not reveal significant contractile dysfunction following LPS administration, as measured by decreased responses in maximal left ventricular pressure, +dP/d tmax, and −dP/d tmaxin ex vivo Langendorff preparations. These findings indicate a requirement for TLR4 in LPS-induced contractile depression. To determine the contribution of bone marrow-derived TLR4 function to LPS-induced myocardial dysfunction, we generated TLR4 chimeras using adoptive transfer between histocompatible mouse strains: either TLR4-deficient mice with TLR4+/+ bone marrow-derived cells or TLR4+/+ animals lacking TLR4 in their hematopoietic cells. We then compared the contractile responses of engrafted animals after LPS challenges. Engraftment of TLR4-deficient mice with WT marrow restored sensitivity to the myocardial depressant effects of LPS in TLR4-deficient hearts ( P < 0.05). Inactivation of bone marrow-derived TLR4 function, via transplantation of WT mice with TLR4−/− marrow, however, did not protect against the depressant effect of endotoxin. These findings indicate that bone marrow-derived TLR4 activity is sufficient to confer sensitivity to mice lacking TLR4 in all other tissues. However, because inactivation of marrow-derived TLR4 function alone does not protect against endotoxin-triggered contractile dysfunction, TLR4 function in other tissues may also contribute to this response.

Tumor Dormancy and the Angiogenic Switch: Possible Implications of Bone Marrow- Derived Cells

2014 ◽  
Vol 20 (30) ◽  
pp. 4920-4933 ◽  
Author(s):  
Yuval Shaked ◽  
Sandra McAllister ◽  
Ofer Fainaru ◽  
Nava Almog
Keyword(s):  
Bone Marrow ◽  
Tumor Dormancy ◽  
Angiogenic Switch ◽  
Bone Marrow Derived Cells

Recent approaches for isolating and culturing mouse bone marrow-derived mesenchymal stromal stem cells

2020 ◽  
Vol 15 ◽  
Author(s):  
Basem M. Abdallah ◽  
Hany M. Khattab
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Molecular Mechanisms ◽  
Replicative Senescence ◽  
Cellular Heterogeneity ◽  
High Yield ◽  
Mouse Strains ◽  
Mouse Bone Marrow ◽  
Differentiation Potential ◽  
Stromal Stem Cells

: The isolation and culture of murine bone marrow-derived mesenchymal stromal stem cells (mBMSCs) have attracted great interest in terms of the pre-clinical applications of stem cells in tissue engineering and regenerative medicine. In addition, culturing mBMSCs is important for studying the molecular mechanisms of bone remodelling using relevant transgenic mice. Several factors have created challenges in the isolation and high-yield expansion of homogenous mBMSCs; these factors include low frequencies of bone marrow-derived mesenchymal stromal stem cells (BMSCs) in bone marrow, variation among inbred mouse strains, contamination with haematopoietic progenitor cells (HPCs), the replicative senescence phenotype and cellular heterogeneity. In this review, we provide an overview of nearly all protocols used for isolating and culturing mBMSCs with the aim of clarifying the most important guidelines for culturing highly purified mBMSC populations retaining in vitro and in vivo differentiation potential.

scholarly journals TMIC-16. THE IMMUNO-PROTECTIVE FUNCTION OF GLIOMA-ASSOCIATED BONE MARROW DERIVED CELLS DEPENDS ON THE STAGE OF TUMOR GROWTH AND IS INFLUENCED BY TREATMENT WITH MINOCYCLINE

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi246-vi246
Author(s):  
Sheila Mansouri ◽  
Kelly Burrell ◽  
Mamatjan Yasin ◽  
Sameer Agnihotri ◽  
Romina Nejad ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tumor Growth ◽  
Protective Function ◽  
Bone Marrow Derived Cells

scholarly journals Exploring the anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells from mice

FEBS Letters ◽  
2014 ◽  
Vol 588 (17) ◽  
pp. 2921-2927 ◽  
Author(s):  
Alicja Trebinska ◽  
Kari Högstrand ◽  
Alf Grandien ◽  
Ewa A. Grzybowska ◽  
Bengt Fadeel
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Derived Cells

scholarly journals The Balance Between CD45RChigh and CD45RClow CD4 T Cells in Rats Is Intrinsic to Bone Marrow-Derived Cells and Is Genetically Controlled

2001 ◽  
Vol 166 (5) ◽  
pp. 2944-2952 ◽  
Author(s):  
Jean-Francois Subra ◽  
Bastien Cautain ◽  
Emmanuel Xystrakis ◽  
Magali Mas ◽  
Dominique Lagrange ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Cd4 T Cells ◽  
Bone Marrow Derived Cells
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