scholarly journals Restricted adult clonal profiles induced by neonatal immunization. Influence of suppressor T cells.

1983 ◽  
Vol 158 (1) ◽  
pp. 112-125 ◽  
Author(s):  
M A Thompson ◽  
S Raychaudhuri ◽  
M P Cancro
Keyword(s):  
B Cell ◽  
Mechanistic Model ◽  
Strong Relationship ◽  
Specific Response ◽  
Suppressor T Cells ◽  
Cell Repertoire ◽  
Influenza Hemagglutinin ◽  
B Cell Repertoire ◽  
Apparent Loss ◽  
Original Antigenic Sin

The effects of neonatal antigen exposure on the adult B cell repertoire have been examined by characterizing the influenza hemagglutinin (HA)-specific response of adult BALB/c mice given antigen soon after birth. Ligand exposure during early life exerts a profound and lasting effect upon the B cell repertoire, characterized by the expansion and preservation of particular antigen-reactive clones and the apparent loss of others. The precise subset of clonotypes selectively preserved depends upon the age at which antigen is first encountered; and is predictable given a knowledge of the emerging primary pool's dynamics and composition. The preserved (secondary) B cells differ from their unprimed precursors with respect to (a) expression of the surface marker detected by the monoclonal antibody J11d, and (b) susceptibility to T cell-mediated suppression. These studies thus demonstrate a strong relationship between the heritable dynamics of the emerging primary B cell repertoire and the effect of ligand-driven events upon repertoire phenotype. In addition, they provide a mechanistic model for certain forms of antigen-induced oligoclonal dominance, especially the phenomenon of original antigenic sin.

scholarly journals B cell repertoire diversity in athymic mice.

1980 ◽  
Vol 151 (3) ◽  
pp. 761-766 ◽  
Author(s):  
M P Cancro ◽  
N R Klinman
Keyword(s):  
B Cell ◽  
Pattern Analysis ◽  
Athymic Mice ◽  
Cell Repertoire ◽  
Reactivity Pattern ◽  
Influenza Hemagglutinin ◽  
Immunoglobulin Allotype ◽  
B Cell Repertoire ◽  
Repertoire Diversity

The extent of B cell repertoire diversity among nu/nu BALB/c mice has been assessed and compared with that of normal BALB/c mice. This was accomplished through the characterization of monoclonal, influenza hemagglutinin-specific antibodies by reactivity pattern analysis. The results indicate that the repertoire of athymic mice is equivalent in diversity to that of normal mice. Moreover, because these responses were obtained in recipients that were histocompatible but distinct at immunoglobulin allotype loci, these findings indicate that a very diverse array of B cell clonotypes may be stimulated in the absence of allotype-identical T cells.

Selection of the expressed B cell repertoire by infusion of normal immunoglobulin G in a patient with autoimmune thyroiditis

1993 ◽  
Vol 23 (11) ◽  
pp. 2945-2950 ◽  
Author(s):  
Gilles Dietrich ◽  
Francisco J. Varela ◽  
Vincent Hurez ◽  
Majida Bouanani ◽  
Michel D. Kazatchkine
Keyword(s):  
B Cell ◽  
Immunoglobulin G ◽  
Autoimmune Thyroiditis ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Selection Of

Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly

Blood ◽  
2004 ◽  
Vol 103 (6) ◽  
pp. 2337-2342 ◽  
Author(s):  
Paolo Ghia ◽  
Giuseppina Prato ◽  
Cristina Scielzo ◽  
Stefania Stella ◽  
Massimo Geuna ◽  
...  
Keyword(s):  
B Cell ◽  
Peripheral Blood ◽  
B Lymphocyte ◽  
The Elderly ◽  
Lymphocytic Leukemia ◽  
Pcr Analysis ◽  
Cell Repertoire ◽  
Healthy Elderly ◽  
B Cell Repertoire ◽  
Igh Genes

Abstract The responsiveness and diversity of peripheral B-cell repertoire decreases with age, possibly because of B-cell clonal expansions, as suggested by the incidence of serum monoclonal immunoglobulins and of monoclonal chronic lymphocytic leukemia (CLL)–like B lymphocytes in clinically silent adults. We phenotyped peripheral blood cells from 500 healthy subjects older than 65 years with no history or suspicion of malignancies and no evidence of lymphocytosis. In 19 cases (3.8%) a κ/λ ratio of more than 3:1 or less than 1:3 was found: 9 were CD5+, CD19+, CD23+, CD20low, CD79blow, sIglow (classic CLL-like phenotype); 3 were CD5+, CD19+, CD23+, CD20high, CD79blow, sIglow (atypical CLL-like), and 7 were CD5-, CD19+, CD20high, CD23-, CD79bbright, FMC7+, sIgbright (non–CLL-like). In 2 subjects, 2 phenotypically distinct unrelated clones were concomitantly evident. No cases were CD10+. Polymerase chain reaction (PCR) analysis demonstrated a monoclonal rearrangement of IgH genes in 15 of 19 cases. No bcl-1 or bcl-2 rearrangements were detected. Using a gating strategy based on CD20/CD5/CD79 expression, 13 additional CLL-like B-cell clones were identified (cumulative frequency of classic CLL-like: 5.5%). Thus, phenotypically heterogeneous monoclonal B-lymphocyte expansions are common among healthy elderly individuals and are not limited to classic CLL-like clones but may have the phenotypic features of different chronic lymphoproliferative disorders, involving also CD5- B cells.

Analysis of Monoclonal Rheumatoid Factors obtained from the B-Cell Repertoire in Rheumatoid Arthritis

1992 ◽  
Vol 35 (2) ◽  
pp. 149-157 ◽  
Author(s):  
M. ABDERRAZIK ◽  
M. MOYNIER ◽  
R JEFFFRIS ◽  
R. A. K. MAGEED ◽  
B. COMBE ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cell ◽  
Rheumatoid Factors ◽  
Cell Repertoire ◽  
B Cell Repertoire

scholarly journals Modified neonatal B-cell repertoire as a consequence of rituximab administration to a pregnant woman

Rheumatology ◽  
2012 ◽  
Vol 52 (2) ◽  
pp. 405-406 ◽  
Author(s):  
M. U. Martinez-Martinez ◽  
L. Baranda-Candido ◽  
R. Gonzalez-Amaro ◽  
O. Perez-Ramirez ◽  
C. Abud-Mendoza
Keyword(s):  
Pregnant Woman ◽  
B Cell ◽  
Cell Repertoire ◽  
B Cell Repertoire

Functional Maturation of B Cell Repertoire Expression

Antibodies ◽  
1987 ◽  
pp. 61-69
Author(s):  
Barbara G. Froscher ◽  
Norman R. Klinman
Keyword(s):  
B Cell ◽  
Cell Repertoire ◽  
Functional Maturation ◽  
B Cell Repertoire

scholarly journals The landscape and diagnostic potential of T and B cell repertoire in Immunoglobulin A Nephropathy

2019 ◽  
Vol 97 ◽  
pp. 100-107 ◽  
Author(s):  
Chen Huang ◽  
Xuemei Li ◽  
Jinghua Wu ◽  
Wei Zhang ◽  
Shiren Sun ◽  
...  
Keyword(s):  
B Cell ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Diagnostic Potential
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