scholarly journals Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.

1981 ◽  
Vol 154 (2) ◽  
pp. 535-540 ◽  
Author(s):  
M A Cremer ◽  
J A Pitcock ◽  
J M Stuart ◽  
A H Kang ◽  
A S Townes
Keyword(s):  
Autoimmune Disease ◽  
Humoral Immunity ◽  
Human Disease ◽  
Wistar Rats ◽  
Causal Relation ◽  
Relapsing Polychondritis ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Auricular Chondritis ◽  
Dense Deposits

Outbred Wistar rats immunized with native type II collagen developed ear lesions resembling those of human relapsing chondritis. As in human disease, these lesions were characterized by intense chondritis, positive immunofluorescence reactions to IgG and C3, and circulating IgG reactive with native type II collagen. Furthermore, electron-dense deposits were seen near the surface of chondrocytes and corresponded with deposits of IgG and C3. These observations suggest a causal relation between humoral immunity to type II collagen and auricular chondritis in the rat and support the hypothesis than human relapsing polychondritis is an autoimmune disease mediated by immunity to type II collagen.

Molecular Basis of Type II Collagen Autoimmune Disease: Observations of Arthritis, Auricular Chondritis and Tympanitis in Mice

ORL ◽  
1997 ◽  
Vol 59 (4) ◽  
pp. 215-229 ◽  
Author(s):  
Tatsuya Fujiyoshi ◽  
Kuang-Chuan Cheng ◽  
Marc S. Krug ◽  
Tai-June Yoo
Keyword(s):  
Autoimmune Disease ◽  
Molecular Basis ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Auricular Chondritis

Case of relapsing polychondritis showing elevation of anti-type II collagen antibody titer

2013 ◽  
Vol 40 (9) ◽  
pp. 767-768 ◽  
Author(s):  
Naomi Tani ◽  
Machiko Ogoshi ◽  
Chika Kawakubo ◽  
Shingo Tajima ◽  
Takahiro Hamada ◽  
...  
Keyword(s):  
Antibody Titer ◽  
Relapsing Polychondritis ◽  
Type Ii Collagen ◽  
Type Ii

scholarly journals Phenotypic characterization of type II collagen-induced arthritis in Wistar rats

2015 ◽  
Vol 10 (4) ◽  
pp. 1483-1488 ◽  
Author(s):  
HOU-PAN SONG ◽  
XIN LI ◽  
RONG YU ◽  
GUANG ZENG ◽  
ZHEN-YI YUAN ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Type Ii Collagen ◽  
Phenotypic Characterization ◽  
Type Ii ◽  
Collagen Induced Arthritis

scholarly journals Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rheumatic diseases.

1981 ◽  
Vol 40 (5) ◽  
pp. 473-479 ◽  
Author(s):  
R Ebringer ◽  
G Rook ◽  
G T Swana ◽  
G F Bottazzo ◽  
D Doniach
Keyword(s):  
Rheumatic Diseases ◽  
Relapsing Polychondritis ◽  
Type Ii Collagen ◽  
Type Ii

Antibodies to Type II Collagen in Relapsing Polychondritis

1978 ◽  
Vol 299 (22) ◽  
pp. 1203-1207 ◽  
Author(s):  
Jean-Michel Foidart ◽  
Shigeto Abe ◽  
George R. Martin ◽  
Thomas M. Zizic ◽  
Eugene V. Barnett ◽  
...  
Keyword(s):  
Relapsing Polychondritis ◽  
Type Ii Collagen ◽  
Type Ii

Type II collagen—induced auricular chondritis

1982 ◽  
Vol 25 (3) ◽  
pp. 266-273 ◽  
Author(s):  
W. Joseph Mccune ◽  
Alan L. Schiller ◽  
Roselynn A. Dynesius-Trentham ◽  
David E. Trentham
Keyword(s):  
Type Ii Collagen ◽  
Type Ii ◽  
Auricular Chondritis

BILATERAL VITREOUS HEMORRHAGES IN A PATIENT WITH RELAPSING POLYCHONDRITIS AND HIGH LEVELS OF TYPE II COLLAGEN ANTIBODIES

Retina ◽  
2000 ◽  
Vol 20 (3) ◽  
pp. 299-301 ◽  
Author(s):  
MABEL L. RODRIGUEZ ◽  
FRANCISCO CAEIRO ◽  
MARTA D. ROMERO-PIFFIGUER ◽  
CLAUDIO P. JUAREZ ◽  
JOSE D. LUNA
Keyword(s):  
Relapsing Polychondritis ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Antibodies

Comparison of inflammatory changes in established type II collagen- and adjuvant-induced arthritis using outbred wistar rats

1985 ◽  
Vol 7 (6) ◽  
pp. 811-826 ◽  
Author(s):  
Richard P. Carlson ◽  
Louis J. Datko ◽  
Lynn O'Neill-Davis ◽  
Eileen M. Blazek ◽  
Frank DeLustro ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Adjuvant Induced Arthritis ◽  
Inflammatory Changes

scholarly journals Urinary type II collagen neoepitope as an outcome measure for relapsing polychondritis

2003 ◽  
Vol 48 (10) ◽  
pp. 2942-2948 ◽  
Author(s):  
Virginia B. Kraus ◽  
Thomas Stabler ◽  
Elizabeth T. Le ◽  
Mary Saltarelli ◽  
Nancy B. Allen
Keyword(s):  
Outcome Measure ◽  
Relapsing Polychondritis ◽  
Type Ii Collagen ◽  
Type Ii

Relapsing polychondritis: autoimmunity to type II collagen and treatment with cyclosporin A

1991 ◽  
Vol 125 (6) ◽  
pp. 588-591 ◽  
Author(s):  
A. ANSTEY ◽  
S. MAYOL ◽  
K. MORGAN ◽  
R.B. CLAGBE ◽  
D.D. MUNRO
Keyword(s):  
Cyclosporin A ◽  
Relapsing Polychondritis ◽  
Type Ii Collagen ◽  
Type Ii
Sign in / Sign up

Export Citation Format

Share Document