scholarly journals Three types of blood group I specificity among monoclonal anti-I autoantibodies revealed by analogues of a branched erythrocyte glycolipid.

1979 ◽  
Vol 149 (4) ◽  
pp. 975-980 ◽  
Author(s):  
T Feizi ◽  
R A Childs ◽  
K Watanabe ◽  
S I Hakomori
Keyword(s):  
Sialic Acid ◽  
Blood Group ◽  
Antigenic Determinants ◽  
The Third ◽  
Group I

Blood group I activities of the purified glycosphingolipid lacto-N-iso-octaosyl ceramide (Fromula: see text) and 8 of its analogues have been evaluated with 11 anti-I sera including 5 anti-I sera previously tested. All but one of the antisera were inhibited by the lacto-N-iso-octaosyl structure. Three types of I-specificity could be distinguished although none of the anti-I sera was identical in its inhibition patterns with the nine glycophingolipid analogues. The anti-I sera Ma and Woj represent the first type and require an intact Galbeta1 leads to 4GlcNAcbeta1 leads to 6 chain, the anti-I sera Step, Gra, Ver, and Ful represent the second type which requires Galbeta1 leads to 4GlcNAcbeta1 leads to 3 chain with branching, and the anti-I sera Phi, Da, Sch, and Low belong to the third type which requires both branches to be intact. Anti-I antibodies varry in their ability to react with their antigenic determinants in the presence of external substitutions with alpha-linked galactose or sialic acid.

scholarly journals Monoclonal antibodies specific for T cell-associated carbohydrate determinants react with human blood group antigens CAD and SDA.

1988 ◽  
Vol 167 (1) ◽  
pp. 119-131 ◽  
Author(s):  
A Conzelmann ◽  
L Lefrancois
Keyword(s):  
Sialic Acid ◽  
T Cell ◽  
Blood Group ◽  
Human Blood ◽  
Antigen Expression ◽  
Intraepithelial Lymphocytes ◽  
Cytotoxic T Cell ◽  
Antigenic Determinants ◽  
Blood Group Antigens ◽  
Human Blood Group

The CT antigenic determinants have previously been shown to be present on the T200 glycoproteins and other proteins of murine cytotoxic T cell clones but not of T helper clones or nonactivated lymphocytes (1, 2). Two determinants recognized by mAbs CT1 and CT2 are also expressed on thymocytes in a developmentally regulated fashion during fetal thymus ontogeny and are found in a subset of Lyt-2+ intraepithelial lymphocytes in the intestinal mucosa (3-5). Previous studies of the biosynthesis of CT+ proteins suggested that these determinants were composed of carbohydrate (8). We now demonstrate that the anti-CT mAbs react with a carbohydrate determinant at the nonreducing terminus of O-linked oligosaccharides that has the configuration GalNAc beta 1,4[SA alpha 2,3]-galactose. The CT antibodies detected this determinant not only on CTL clones but also in the human blood group antigens Cad and Sda+. Variant CTL lines, non-Cad erythrocytes, and Sda- glycoproteins that lacked the GalNAc residue did not bind the CT mAb. Sialic acid was essential for CT antigen expression since neuraminidase or mild periodate treatment abrogated CT antibody binding. In addition, other carbohydrate structures with terminal GalNAc residues such as the A or Tn blood group antigens were not recognized. The CT antibodies thus define GalNAc and sialic acid containing carbohydrate antigens that are expressed on discrete subsets of T lymphocytes and may also be useful reagents for the detection of Cad and Sda+ blood group antigens.

Correlations Between the Values of Maternal Glycemia from the Last Trimester of Pregnancy and Fetal Birth Weight

2013 ◽  
Vol 20 (3) ◽  
pp. 259-265
Author(s):  
Monica Vereş ◽  
Aurel Babeş ◽  
Szidonia Lacziko
Keyword(s):  
First Trimester ◽  
Mean Value ◽  
Fetal Macrosomia ◽  
Entire Group ◽  
Third Trimester ◽  
The Third ◽  
Group I ◽  
Fetal Birth Weight ◽  
First Trimester Of Pregnancy ◽  
The Mean

Abstract Background and aims: Gestational diabetes represents a form of diabetes diagnosed during pregnancy that is not clearly overt diabetes. In the last trimester of gestation the growth of fetoplacental unit takes place, thus maternal hyperglycemia will determine an increased transplacental passage, hyperinsulinemia and fetal macrosomia. The aim of our study was that o analyzing the effect of maternal glycemia from the last trimester of pregnancy over fetal weight. Material and method: We run an observational study on a group of 46 pregnant women taken into evidence from the first trimester of pregnancy, separated in two groups according to blood glucose determined in the third trimester (before birth): group I normoglycemic and group II with hyperglycemia (>92mg/dl). Results: The mean value of third trimester glycemia for the entire group was of 87.13±22.03. The mean value of the glycemia determined in the third trimester of pregnancy was higher in the second group (109.17 mg/dl) in comparison to the first group (74.,21 mg/dl). The ROC curve for third trimester glycemia as fetal macrosomia appreciation test has an AUC of 0.517. Conclusions: Glycemia determined in the last trimester of pregnancy cannot be used alone as the predictive factor for fetal macrosomia.

Structural analysis of hexa- to octa-saccharide fractions isolated from sheep gastric-glycoproteins having blood-group I and i activities

1981 ◽  
Vol 90 (2) ◽  
pp. 283-307 ◽  
Author(s):  
Elizabeth F. Hounsell ◽  
Edwin Wood ◽  
Ten Feizi ◽  
Minoru Fukuda ◽  
Mark E. Powell ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Blood Group ◽  
Group I

scholarly journals The role of sialic acid in the expression of human MN blood group antigens.

1979 ◽  
Vol 254 (6) ◽  
pp. 2112-2119 ◽  
Author(s):  
J.E. Sadler ◽  
J.C. Paulson ◽  
R.L. Hill
Keyword(s):  
Sialic Acid ◽  
Blood Group ◽  
Blood Group Antigens ◽  
Mn Blood Group

scholarly journals Characterization of a blood group I-active ganglioside. Structural requirements for I and i specificities.

1979 ◽  
Vol 254 (9) ◽  
pp. 3221-3228 ◽  
Author(s):  
K Watanabe ◽  
S I Hakomori ◽  
R A Childs ◽  
T Feizi
Keyword(s):  
Blood Group ◽  
Structural Requirements ◽  
Group I

scholarly journals Rotavirus VP8*: Phylogeny, Host Range, and Interaction with Histo-Blood Group Antigens

2012 ◽  
Vol 86 (18) ◽  
pp. 9899-9910 ◽  
Author(s):  
Yang Liu ◽  
Pengwei Huang ◽  
Ming Tan ◽  
Yiliu Liu ◽  
Jacek Biesiada ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Blood Group ◽  
Binding Assay ◽  
Distal Portion ◽  
Carbohydrate Binding ◽  
Blood Group Antigens ◽  
Independent Manner ◽  
Viral Attachment ◽  
Mutagenesis Study ◽  
Binding Interfaces

The distal portion of rotavirus (RV) VP4 spike protein (VP8*) is implicated in binding to cellular receptors, thereby facilitating viral attachment and entry. While VP8* of some animal RVs engage sialic acid, human RVs often attach to and enter cells in a sialic acid-independent manner. A recent study demonstrated that the major human RVs (P[4], P[6], and P[8]) recognize human histo-blood group antigens (HBGAs). In this study, we performed a phylogenetic analysis of RVs and showed further variations of RV interaction with HBGAs. On the basis of the VP8* sequences, RVs are grouped into five P genogroups (P[I] to P[V]), of which P[I], P[IV], and P[V] mainly infect animals, P[II] infects humans, and P[III] infects both animals and humans. The sialic acid-dependent RVs (P[1], P[2], P[3], and P[7]) form a subcluster within P[I], while all three major P genotypes of human RVs (P[4], P[6], and P[8]) are clustered in P[II]. We then characterized three human RVs (P[9], P[14], and P[25]) in P[III] and observed a new pattern of binding to the type A antigen which is distinct from that of the P[II] RVs. The binding was demonstrated by hemagglutination and saliva binding assay using recombinant VP8* and native RVs. Homology modeling and mutagenesis study showed that the locations of the carbohydrate binding interfaces are shared with the sialic acid-dependent RVs, although different amino acids are involved. The P[III] VP8* proteins also bind the A antigens of the porcine and bovine mucins, suggesting the A antigen as a possible factor for cross-species transmission of RVs. Our study suggests that HBGAs play an important role in RV infection and evolution.

About the blood group identity of paralytics

1927 ◽  
Vol 23 (6-7) ◽  
pp. 748-749
Author(s):  
M. Kashevarova
Keyword(s):  
Blood Group ◽  
Group Identity ◽  
Group I

Jacobsohn reports the results of a study of 100 progressive paraplegics as to their blood group identity (by Jansk): group I-33%, II-47%, III-17%, and IV-3%.

Structure and blood-group I activity of poly(glycosyl)-ceramides

1983 ◽  
Vol 120 ◽  
pp. 113-130 ◽  
Author(s):  
Ewa Zdebska ◽  
Robert Krauze ◽  
Jerzy Kościelak
Keyword(s):  
Blood Group ◽  
Group I
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