scholarly journals QUANTITATIVE STUDIES OF NATURALLY OCCURRING MURINE LEUKEMIA VIRUS INFECTION OF AKR MICE

1972 ◽  
Vol 135 (2) ◽  
pp. 429-436 ◽  
Author(s):  
Wallace P. Rowe ◽  
Theodore Pincus
Keyword(s):  
Virus Infection ◽  
Murine Leukemia Virus ◽  
Infectious Virus ◽  
Leukemia Virus ◽  
Organ Distribution ◽  
Thymic Lymphoma ◽  
Quantitative Studies ◽  
Naturally Occurring ◽  
Akr Mice ◽  
Murine Leukemia

Quantitative studies were made of the organ distribution of murine leukemia virus in AKR mice of various ages. Infectious virus first appeared shortly before or after birth and was continuously present in all mice thereafter. Highest infectivity titers were found in uterus and bone, with spleen slightly lower. Virus titers in normal thymus were relatively low, but increased significantly with the development of thymic lymphoma. The level of viremia decreased after the 1st month of life, but increased sharply in lymphomatous mice.

scholarly journals STUDIES OF GENETIC TRANSMISSION OF MURINE LEUKEMIA VIRUS BY AKR MICE

1972 ◽  
Vol 136 (5) ◽  
pp. 1272-1285 ◽  
Author(s):  
Wallace P. Rowe
Keyword(s):  
Linkage Group ◽  
Murine Leukemia Virus ◽  
Infectious Virus ◽  
Leukemia Virus ◽  
Backcross Generation ◽  
Genetic Transmission ◽  
Group I ◽  
Akr Mice ◽  
Chromosomal Loci ◽  
Murine Leukemia

AKR mice, which regularly contain infectious murine leukemia virus, were mated with four Fv-1n strains of mice which show little or no expression of virus. F1, F2, and first and second backcross generation hybrids were tested for virus in tail tissue at 2 and 6 wk of age. The segregation data indicate that the AKR mouse contains two unlinked, autosomal, chromosomal loci, either of which suffices to induce detectable levels of infectious virus in Fv-1n progeny by 6 wk of age. One of the loci (tentatively referred to as V1) is on linkage group I, 25–30 map units from the locus for albino; the gene order tentatively appears to be N1-c-Hbb.

scholarly journals Suppression of endogenous murine leukemia virus by maternal resistance factor.

1983 ◽  
Vol 158 (2) ◽  
pp. 506-514 ◽  
Author(s):  
M Melamedoff ◽  
F Lilly ◽  
M L Duran-Reynals
Keyword(s):  
Murine Leukemia Virus ◽  
Infectious Virus ◽  
Leukemia Virus ◽  
Inbred Mouse ◽  
Resistance Factor ◽  
Mouse Strains ◽  
B Mice ◽  
Akr Mice ◽  
Old Females ◽  
Murine Leukemia

Females of the RF and SJL inbred mouse strains transmit to their progeny of both sexes a nonmendelian maternal resistance factor (MRF) able to suppress the expression of endogenous ecotropic murine leukemia virus (E-MuLV). This MRF is demonstrable in crosses with AKR mice by comparing E-MuLV expression in the spleens and thymuses of reciprocal F1 generations. DBA/2 and ST/b mice are MRF negative by these criteria. Neonatal inoculation of E-MuLV-containing spleen extracts gives rise to persistent expression of infectious virus in mice of the MRF- but not the MRF+ strains. However, inoculation of the virus in 30-d-old females of the MRF- strains no longer leads to a state of persistent infection; instead, these females become MRF+ and transmit protection against E-MuLV expression to their progeny by AKR and RF males. The MRF appears to be transmitted to the progeny mainly through the milk, since foster-nursing AKR neonates on RF (but not DBA/2) mothers greatly reduces E-MuLV expression in the progeny. These RF-fostered AKR mice also show a reduced and delayed lymphoma incidence, a finding consistent with the idea that maternally transmitted resistance to E-MuLV expression is the basis for the classic maternal resistance to lymphomagenesis seen in the progeny of RF mothers.

Effect of interferon on the exogenous friend murine leukemia virus infection

Virology ◽  
1982 ◽  
Vol 118 (1) ◽  
pp. 202-213 ◽  
Author(s):  
Charles H. Riggin ◽  
Paula M. Pithai
Keyword(s):  
Virus Infection ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Murine Leukemia

scholarly journals Amplified env and gag products on AKR cells. Origin from different murine leukemia virus genomes.

1980 ◽  
Vol 151 (4) ◽  
pp. 975-979 ◽  
Author(s):  
J S Tung ◽  
E Fleissner
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Mouse Strains ◽  
Type Antigen ◽  
Mink Cell ◽  
Virus Expression ◽  
Virus Genomes ◽  
Akr Mice ◽  
Ecotropic Virus ◽  
Murine Leukemia

Thymocytes of AKR mice express two species of gp70, the envelope glycoprotein of murine leukemia virus (MuLV), encoded by the env gene. One is denoted Ec+ gp70 in reference to the type-antigen Ec and association with ecotropic virus. The other, Ec- gp70, resembles gp70 found also on thymocytes of mouse strains that are not overt producers of MuLV, and has no evident relation to ecotropic virus. Expression of Ec- gp70 type, but not of Ec+ gp70 type, is amplified with age on AKR thymocytes. In contrast, viral core polyproteins, encoded by the gag gene and simultaneously amplified with age, appear to be related to ecotropic virus. These observations imply selective amplification of products of env and gag genes from two sorts of provirus, a phenomenon which may be connected to the dual genetic origin of recombinant mink-cell-focus inducing viruses in AKR mice.

scholarly journals Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection

2011 ◽  
Vol 8 (1) ◽  
pp. 443 ◽  
Author(s):  
Veerasamy Ravichandran ◽  
Eugen O Major ◽  
Carol Ibe ◽  
Maria Monaco ◽  
Mohan Girisetty ◽  
...  
Keyword(s):  
Virus Infection ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Neuronal Cells ◽  
Xenotropic Murine Leukemia ◽  
Primary Neuronal Cells ◽  
Murine Leukemia
Sign in / Sign up

Export Citation Format

Share Document