IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

2009 ◽  
Vol 186 (1) ◽  
pp. i2-i2
Author(s):  
Lin Wang ◽  
Tangsheng Yi ◽  
Marcin Kortylewski ◽  
Drew M. Pardoll ◽  
Defu Zeng ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Signaling Pathway ◽  
Stat3 Signaling ◽  
Promote Tumor Growth ◽  
Stat3 Signaling Pathway

scholarly journals Diet-Induced Obesity Increases Tumor Growth and Promotes Anaplastic Change in Thyroid Cancer in a Mouse Model

Endocrinology ◽  
2013 ◽  
Vol 154 (8) ◽  
pp. 2936-2947 ◽  
Author(s):  
Won Gu Kim ◽  
Jeong Won Park ◽  
Mark C. Willingham ◽  
Sheue-yann Cheng
Keyword(s):  
Thyroid Cancer ◽  
Mouse Model ◽  
Tumor Growth ◽  
Signaling Pathway ◽  
Thyroid Tumor ◽  
Janus Kinase ◽  
Histopathological Analysis ◽  
Diet Induced Obesity ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

Abstract Recent epidemiological studies provide strong evidence suggesting obesity is a risk factor in several cancers, including thyroid cancer. However, the molecular mechanisms by which obesity increases the risk of thyroid cancer are poorly understood. In this study, we evaluated the effect of diet-induced obesity on thyroid carcinogenesis in a mouse model that spontaneously develops thyroid cancer (ThrbPV/PVPten+/− mice). These mice harbor a mutated thyroid hormone receptor-β (denoted as PV) and haplodeficiency of the Pten gene. A high-fat diet (HFD) efficiently induced the obese phenotype in ThrbPV/PVPten+/− mice after 15 weeks. Thyroid tumor growth was markedly greater and survival was significantly lower in ThrbPV/PVPten+/− mice fed an HFD than in controls fed a low-fat diet (LFD). The HFD increased thyroid tumor cell proliferation by increasing the protein levels of cyclin D1 and phosphorylated retinoblastoma protein to propel cell cycle progression. Histopathological analysis showed that the frequency of anaplasia of thyroid cancer was significantly greater (2.6-fold) in the HFD group than the LFD group. The HFD treatment led to an increase in parametrial/epididymal fat pad and elevated serum leptin levels in ThrbPV/PVPten+/− mice. Further molecular analyses indicated that the HFD induced more aggressive pathological changes that were mediated by increased activation of the Janus kinase 2-signaling transducer and activator of transcription 3 (STAT3) signaling pathway and induction of STAT3 target gene expression. Our findings demonstrate that diet-induced obesity exacerbates thyroid cancer progression in ThrbPV/PVPten+/− mice and suggest that the STAT3 signaling pathway could be tested as a potential target for the treatment of thyroid cancer.

scholarly journals IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

2009 ◽  
Vol 206 (7) ◽  
pp. 1457-1464 ◽  
Author(s):  
Lin Wang ◽  
Tangsheng Yi ◽  
Marcin Kortylewski ◽  
Drew M. Pardoll ◽  
Defu Zeng ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Stromal Cells ◽  
Signal Transducer ◽  
Direct Effects ◽  
Th17 Response ◽  
Stat3 Signaling ◽  
Promote Tumor Growth ◽  
Stat3 Signaling Pathway ◽  
Ifn Γ

Although the Th17 subset and its signature cytokine, interleukin (IL)-17A (IL-17), are implicated in certain autoimmune diseases, their role in cancer remains to be further explored. IL-17 has been shown to be elevated in several types of cancer, but how it might contribute to tumor growth is still unclear. We show that growth of B16 melanoma and MB49 bladder carcinoma is reduced in IL-17−/− mice but drastically accelerated in IFN-γ−/− mice, contributed to by elevated intratumoral IL-17, indicating a role of IL-17 in promoting tumor growth. Adoptive transfer studies and analysis of the tumor microenvironment suggest that CD4+ T cells are the predominant source of IL-17. Enhancement of tumor growth by IL-17 involves direct effects on tumor cells and tumor-associated stromal cells, which bear IL-17 receptors. IL-17 induces IL-6 production, which in turn activates oncogenic signal transducer and activator of transcription (Stat) 3, up-regulating prosurvival and proangiogenic genes. The Th17 response can thus promote tumor growth, in part via an IL-6–Stat3 pathway.

scholarly journals Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathway

2019 ◽  
Vol 8 (17) ◽  
pp. 7345-7358 ◽  
Author(s):  
Shangyu Wang ◽  
Hongzhi Hu ◽  
Binlong Zhong ◽  
Deyao Shi ◽  
Xiangcheng Qing ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tumor Growth ◽  
Signaling Pathway ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway
Sign in / Sign up

Export Citation Format

Share Document