scholarly journals Sensory adaptation of leukocytes to chemotactic peptides.

1979 ◽  
Vol 82 (2) ◽  
pp. 517-527 ◽  
Author(s):  
S H Zigmond ◽  
S J Sullivan
Keyword(s):  
Dose Range ◽  
Behavioral Changes ◽  
Chemotactic Factor ◽  
Peptide Concentration ◽  
Transient Nature ◽  
Chemotactic Peptides ◽  
Round Form ◽  
Chemotactic Factors ◽  
Leukocyte Chemotaxis ◽  
And Behavior

The morphology and behavior of polymorphonuclear leukocytes (PMNs) were studied after rapid changes in the concentration of a chemotactic factor N-formylnorleucylleucylphenylalanine (f-NorleuLeuPhe) (Schiffmann et al., 1975, Proc. Natl. Acad. Sci. U. S. A. 72:1059--1062). After an increase in peptide concentration, the cells round, form lamellipodia or ruffles over most of their surface, and stop locomotion. These changes are transient. After a delay, the cells, still in the presence of peptide, withdraw most of the ruffles and resume locomotion, forming ruffles only at their front. Cells repeat the transient generalized ruffling upon further increase in peptide concentration. The behavioral changes occur over the same dose range as binding to a saturable receptor. The duration of the transient response after a concentration increase is roughly proportional to the increase in the number of cell receptors occupied as a result of the concentration change. Decreasing the concentration of peptide causes the cells to round transiently and form blebs before they recommence locomotion. The transient nature of these aspects of the cell's responsiveness to chemotactic factors appears to be due to adaptation by the cells. The ability to adapt to the concentration of a chemotactic factor may be important in leukocyte chemotaxis.

The Inhibitory Effect of Heparin and Related Glycosaminoglycans on Neutrophil Chemotaxis

1984 ◽  
Vol 52 (02) ◽  
pp. 134-137 ◽  
Author(s):  
Yaacov Matzner ◽  
Gerard Marx ◽  
Ruth Drexler ◽  
Amiram Eldor
Keyword(s):  
Specific Binding ◽  
Anticoagulant Activity ◽  
Neutrophil Migration ◽  
Inhibitory Effect ◽  
Chemotactic Factor ◽  
Human Neutrophils ◽  
Boyden Chamber ◽  
Neutrophil Chemotaxis ◽  
Inhibitory Effects ◽  
Chemotactic Factors

SummaryClinical observations have shown that heparin has antiinflammatory activities. The effect of heparin on neutrophil chemotaxis was evaluated in vitro in the Boyden Chamber. This method enabled differentiation between the direct effects of heparin on neutrophil migration and locomotion, and its effects on chemotactic factors. Heparin inhibited both the random migration and directed locomotion of human neutrophils toward zymosan-activated serum (ZAS) and F-met-leu-phe (FMLP). Inhibition was found to be dependent on the concentrations of the heparin and of the chemotactic factors. No specific binding of heparin to the neutrophils could be demonstrated, and heparin’s inhibitory effects were eliminated by simple washing of the cells. When added directly to the chamber containing chemotactic factor, heparin inhibited the chemotactic activity of ZAS but not that of FMLP, suggesting a direct inhibitory effect against C5a, the principal chemotactic factor in ZAS.Experiments performed with low-molecular-weight heparin, N-desulfated heparin, dextran sulfate, chondroitin sulfate and dextran indicated that the inhibitory effects of heparin on neutrophil chemotaxis are not related to its anticoagulant activity, but probably depend on the degree of sulfation of the heparin molecule.

scholarly journals Exploring Farmers’ Reasons for Antibiotic Use and Misuse in Pig Farms in Brazil

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 331
Author(s):  
Rita Albernaz-Gonçalves ◽  
Gabriela Olmos ◽  
Maria José Hötzel
Keyword(s):  
Social Factors ◽  
Antibiotic Use ◽  
Behavioral Changes ◽  
Foreign Markets ◽  
Treatment Length ◽  
Key Stakeholders ◽  
Prevention And Treatment ◽  
Pig Farms ◽  
Unrestricted Access ◽  
And Behavior

Stressful management that makes farmed pigs susceptible to infections is associated with high antibiotic use (AMU) and resistance (AMR). Pig farmers are key stakeholders to support the international agenda pushing AMU restrictions. We interviewed 58 pig farmers on AMU/AMR, biosecurity, veterinary assistance, disease prevention and treatment, aiming to understand practices and attitudes towards the AMU/AMR problem. Farmers described a reliance on antibiotics to prevent and treat disease while neglecting biosecurity measures. We identified inappropriate AMU practices (high use of broad-spectrum antibiotics, incorrect dosage or treatment length) and unrestricted access to antibiotics, which encouraged imprudent AMU. Nevertheless, most farmers considered this AMU legitimate to guarantee herd productivity and showed unpreparedness and resistance to changing AMU practices, perceiving limitations (economic, sanitary and inspection) more easily than alternatives to reduce AMU. Agro-industries and foreign markets were mentioned, and internal consumers dismissed as potential motivators for behavioral changes. Importantly, farmers’ economic, technical and social factors may limit their autonomy to change practices. We conclude that the observed distancing of pig farmers from the AMU/AMR problem limits the efficiency of policies aiming for a prudent AMU. Our study indicates a need for education, training and behavior change nudging that should include other stakeholders beyond farmers.

scholarly journals Aplikasi Teori Behavioristik dan Konstruktifistik dalam Kegiatan Pembelajaran di Sekolah Tinggi Ilmu Tarbiyah Raden Wijaya Mojokerto

2017 ◽  
Vol 6 (2) ◽  
pp. 33
Author(s):  
Akhmad Pandu Setiawan
Keyword(s):  
Learning Theory ◽  
Positive Reinforcement ◽  
Cognitive Learning ◽  
Behavioral Changes ◽  
Negative Evaluation ◽  
Learning Approaches ◽  
The Road ◽  
And Behavior ◽  
Desirable Behavior

Behaviorism learning theory is oriented towards results that can be measured and observed. Repetition and training used so that the desired behavior can become a habit. The expected results of the implementation of this behavioristic theory is the formation of a desired behavior. The desirable behavior gets positive reinforcement and behavior that is not appropriate awarded the negative. Evaluation or assessment based on observed behavior. In theory this learned professor was not much give a lecture, but the brief instruction is followed by examples by themselves or through simulation. The purpose of this paper is to describe the application of the theory Behavioristic and konstruktifistik in learning activities at the School of Raden Wijaya Tarbiyah Mojokerto. Behavioristic learning theory emphasizes the changes in behavior as well as a result of the interaction between stimulus and response. Learning is a process of behavioral changes as a result of the interaction between stimulus and response. A person is considered to have learned if he could show changes in behavior. Although learning theory tigkah behavior began to be abandoned century, but collaborate on this theory with cognitive learning theory and the theory of other learning is essential for creating a learning approach that is appropriate and effective, because basically there is no single theory of learning that is truly suited to creating a learning approaches and effective fit. especially with constructivism learning model. The role of the faculty in constructivist learning very demanding mastery of a broad and in-depth about the material taught. A broad and deep knowledge allow a lecturer accept different views and ideas of students and also makes it possible to indicate whether or not the idea of ​​the road. Mastery of the material allows a professor to understand all kinds of roads and the model to arrive at a solution to the problem without fixed on one model.

scholarly journals Comparative metagenomic analysis following treatment with vancomycin in C57BL/6 and BALB/c mice to elucidate host immunity and behavior

2020 ◽  
Author(s):  
Pratikshya Ray ◽  
Debasmita Das ◽  
Uday Pandey ◽  
Palok Aich
Keyword(s):  
Gut Microbiota ◽  
Normal Level ◽  
Significant Rise ◽  
Host Immunity ◽  
Behavioral Changes ◽  
Metagenomic Analysis ◽  
Initial Increase ◽  
Host Behavior ◽  
And Behavior ◽  
Kinetics Of

AbstractThe gut is the largest reservoir of the resident microbiota. The microbiota can affect the host behavior and immunity. While the consequence of treatment with antibiotics on the gut microbiota can be destructive but can be utilized as a tool to understand the host immunity and behavior. The magnitude of perturbation and time needed for the restoration of gut microbiota can depend on the immune bias of the host. In the current study, we therefore, observed the perturbation and restoration kinetics of gut microbiota following treatment with vancomycin and its effect on the host physiology in both Th1-(C57BL/6) and Th2-(BALB/c) biased mice. A comparative metagenomic analysis revealed that the treatment with vancomycin caused a significant decrease in the abundance of Firmicutes and Bacteroidetes phyla and an initial increase in Proteobacteria. Increase in Proteobacteria decreased with continued treatment with vancomycin to result into a significant rise in Verrucomicrobia phylum. We established the patterns of gut microbiota alteration and its effect on a) the behavior of mice, b) expression of key brain molecules and b) immunity related genes. We followed the gut microbiome restoration for a period of two months following withdrawal of treatment with vancomycin. Maximum restoration (>70%) of gut microbiota happened by the 15th day of withdrawal. BALB/c mice showed a more efficient restoration of gut microbiota compared to C57BL/6 mice. The results, in general, revealed that along with the restoration of major gut microbes, important physiological and behavioral changes of both mice strains returned to the normal level.

Behavioral Effects of Prenatal and Adult Exposure To Toxic Chemicals Found in Lake Ontario Fish: Two Methodological Approaches

1996 ◽  
Vol 12 (3-4) ◽  
pp. 419-426 ◽  
Author(s):  
Helen Daly ◽  
Thomas Darvill ◽  
Edward Lonky ◽  
Jacqueline Reihman ◽  
David Sargent
Keyword(s):  
Human Subjects ◽  
Lake Ontario ◽  
Behavioral Changes ◽  
Laboratory Rats ◽  
Confounding Variables ◽  
Correlational Method ◽  
And Behavior ◽  
And Control ◽  
Adult Exposure ◽  
To Receive

Two research approaches are described that were used to determine behavioral changes following a diet of Lake Ontario fish. Approach 1 involved the correlational method, in which human subjects voluntarily ate contaminated Lake Ontario fish. Demographic information, data on the amount of Lake Ontario fish consumed, and control variables were obtained during an interview. Respondents' behavior, as well as the behavior of their children, then was measured. Because subjects were not assigned randomly to eat or not eat Lake Ontario fish, other variables that might have influenced both consumption of fish and behavior had to be considered. Therefore, confounding variables were measured and their influence controlled for using statistical techniques. Approach 2 involved the experimental method using laboratory rats, where subjects were assigned randomly to receive a diet of environmentally contaminated Lake Ontario salmon, relatively uncontaminated Pacific Ocean salmon, or no salmon. Since the rats fed Lake Ontario salmon behaved differently than the other two groups on nine tasks, it was concluded that the contaminants in Lake Ontario salmon caused behavioral changes. Random assignment of subjects to groups eliminated competing explanations. If similar behavioral (e.g., emotional or cognitive) results were obtained using the two approaches, then the results utilizing rats probably could be generalized to humans, and the correlational results found in humans probably were due to a cause and effect relationship.

Beyond supervised therapy: Promoting behavioral changes in people with MS

2019 ◽  
Vol 25 (10) ◽  
pp. 1379-1386
Author(s):  
Matthew Plow ◽  
Marcia Finlayson
Keyword(s):  
Behavior Change ◽  
Randomized Clinical Trials ◽  
Behavioral Changes ◽  
Change Strategies ◽  
Healthy Behaviors ◽  
Behavior Change Wheel ◽  
Delivery Format ◽  
Behavior Change Technique ◽  
And Behavior ◽  
And Training

A critical aspect of many rehabilitation interventions for people with multiple sclerosis (MS) is incorporating strategies that support behavior change. The main purpose of this topical review was to summarize recent randomized clinical trials (RCTs) of rehabilitation interventions in which participants learn and apply skills or engage in healthy behaviors. The Capability, Opportunity, Motivation, and Behavior (COM-B) framework was used to broadly classify behavior-change strategies. The included RCTs varied widely in terms of dosing, delivery format, and types of interventionist. Commonly used behavior-change strategies include education, persuasion, and training. We recommend that researchers and clinicians use frameworks like Behavior Change Wheel and Behavior Change Technique Taxonomy to describe and classify intervention strategies used to promote behavior change. We also recommend more sophisticated RCTs be conducted (e.g. sequential multiple assignment randomized trial and three-arm RCTs) to better understand ways of promoting behavior change in rehabilitation interventions.

Risk perception, self-efficacy, trust for physician, depression, and behavior modification in diabetic patients

2017 ◽  
Vol 25 (3) ◽  
pp. 350-360 ◽  
Author(s):  
Hissei Imai ◽  
Toshiaki A Furukawa ◽  
Shin-u Hayashi ◽  
Atsushi Goto ◽  
Kazuo Izumi ◽  
...  
Keyword(s):  
Health Promotion ◽  
Risk Perception ◽  
Behavior Modification ◽  
Self Efficacy ◽  
Food Habits ◽  
Depressive Mood ◽  
Behavioral Changes ◽  
Diabetic Patients ◽  
Health Promotion Behaviors ◽  
And Behavior

We evaluated the associations of risk perception, self-efficacy, and trust with two health promotion behaviors (food habits and exercise) and depressive mood. Diabetic patients aged between 40 and 64 ( n = 1195) were included in the analyses. Risk perception worsened behavioral changes in terms of food habits and depression, whereas self-efficacy and trust improved food habits, exercise, and depression; trust improved exercise and depression. In conclusion, self-efficacy and trust appear to be more beneficial than risk perception for positive behavioral changes and for improving depression in diabetic patients. However, their influence on behavioral changes may be different according to the types of behaviors.

scholarly journals Exploring the Interactions Between Neurophysiology and Cognitive and Behavioral Changes Induced by a Non-pharmacological Treatment: A Network Approach

2021 ◽  
Vol 13 ◽  
Author(s):  
Víctor Rodríguez-González ◽  
Carlos Gómez ◽  
Hideyuki Hoshi ◽  
Yoshihito Shigihara ◽  
Roberto Hornero ◽  
...  
Keyword(s):  
Behavioral Changes ◽  
Pharmacological Intervention ◽  
Functional Impairments ◽  
Complex Interactions ◽  
Before And After ◽  
Neurophysiological Data ◽  
Behavior Disturbance ◽  
And Behavior ◽  
State Examination ◽  
Personalized Intervention

Dementia due to Alzheimer’s disease (AD) is a neurological syndrome which has an increasing impact on society, provoking behavioral, cognitive, and functional impairments. AD lacks an effective pharmacological intervention; thereby, non-pharmacological treatments (NPTs) play an important role, as they have been proven to ameliorate AD symptoms. Nevertheless, results associated with NPTs are patient-dependent, and new tools are needed to predict their outcome and to improve their effectiveness. In the present study, 19 patients with AD underwent an NPT for 83.1 ± 38.9 days (mean ± standard deviation). The NPT was a personalized intervention with physical, cognitive, and memory stimulation. The magnetoencephalographic activity was recorded at the beginning and at the end of the NPT to evaluate the neurophysiological state of each patient. Additionally, the cognitive (assessed by means of the Mini-Mental State Examination, MMSE) and behavioral (assessed in terms of the Dementia Behavior Disturbance Scale, DBD-13) status were collected before and after the NPT. We analyzed the interactions between cognitive, behavioral, and neurophysiological data by generating diverse association networks, able to intuitively characterize the relationships between variables of a different nature. Our results suggest that the NPT remarkably changed the structure of the association network, reinforcing the interactions between the DBD-13 and the neurophysiological parameters. We also found that the changes in cognition and behavior are related to the changes in spectral-based neurophysiological parameters. Furthermore, our results support the idea that MEG-derived parameters can predict NPT outcome; specifically, a lesser degree of AD neurophysiological alterations (i.e., neural oscillatory slowing, decreased variety of spectral components, and increased neural signal regularity) predicts a better NPT prognosis. This study provides deeper insights into the relationships between neurophysiology and both, cognitive and behavioral status, proving the potential of network-based methodology as a tool to further understand the complex interactions elicited by NPTs.

scholarly journals Species-Specific Flash Patterns Track the Nocturnal Behavior of Sympatric Taiwanese Fireflies

Biology ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 58
Author(s):  
King-Siang Goh ◽  
Chia-Ming Lee ◽  
Tzi-Yuan Wang
Keyword(s):  
Sympatric Species ◽  
Behavioral Changes ◽  
Behavior Changes ◽  
Sympatric Population ◽  
Flash Duration ◽  
Spatiotemporal Analyses ◽  
Species Specific ◽  
Suitable Reference ◽  
And Behavior

It is highly challenging to evaluate the species’ content and behavior changes in wild fireflies, especially for a sympatric population. Here, the flash interval (FI) and flash duration (FD) of flying males from three sympatric species (Abscondita cerata, Luciola kagiana, and Luciola curtithorax) were investigated for their potentials in assessing species composition and nocturnal behaviors during the A. cerata mating season. Both FI and FD were quantified from the continuous flashes of adult fireflies (lasting 5–30 s) via spatiotemporal analyses of video recorded along the Genliao hiking trail in Taipei, Taiwan. Compared to FD patterns and flash colors, FI patterns exhibited the highest species specificity, making them a suitable reference for differentiating firefly species. Through the case study of a massive occurrence of A. cerata (21 April 2018), the species contents (~85% of the flying population) and active periods of a sympatric population comprising A. cerata and L. kagiana were successfully evaluated by FI pattern matching, as well as field specimen collections. Our study suggests that FI patterns may be a reliable species-specific luminous marker for monitoring the behavioral changes in a sympatric firefly population in the field, and has implication values for firefly conservation.

scholarly journals Hormonal control of motivational circuitry orchestrates the transition to sexuality in Drosophila

2021 ◽  
Vol 7 (25) ◽  
pp. eabg6926
Author(s):  
Stephen X. Zhang ◽  
Ethan H. Glantz ◽  
Lauren E. Miner ◽  
Dragana Rogulja ◽  
Michael A. Crickmore
Keyword(s):  
Hormonal Control ◽  
Behavioral Changes ◽  
Complete Suppression ◽  
Hormonal Changes ◽  
Organizational Changes ◽  
Neuronal Circuitry ◽  
Young Males ◽  
Inhibitory Mechanisms ◽  
Circuit Elements ◽  
And Behavior

Newborns and hatchlings can perform incredibly sophisticated behaviors, but many animals abstain from sexual activity at the beginning of life. Hormonal changes have long been known to drive both physical and behavioral changes during adolescence, leading to the largely untested assumption that sexuality emerges from organizational changes to neuronal circuitry. We show that the transition to sexuality in male Drosophila is controlled by hormonal changes, but this regulation is functional rather than structural. In very young males, a broadly acting hormone directly inhibits the activity of three courtship-motivating circuit elements, ensuring the complete suppression of sexual motivation and behavior. Blocking or overriding these inhibitory mechanisms evokes immediate and robust sexual behavior from very young and otherwise asexual males. Similarities to mammalian adolescence suggest a general principle in which hormonal changes gate the transition to sexuality not by constructing new circuitry but by permitting activity in otherwise latent motivational circuit elements.

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