scholarly journals Retention of amylase in the secretory granules of parotid gland after extensive release of Ca++ by ionophore A-23187.

1977 ◽  
Vol 74 (3) ◽  
pp. 789-793 ◽  
Author(s):  
Y Flashner ◽  
M Schramm
Keyword(s):  
Parotid Gland ◽  
Secretory Granules ◽  
Secretory Proteins ◽  
Stabilizing Agent ◽  
A 23187 ◽  
Rat Parotid Gland ◽  
Rat Parotid ◽  
Extensive Release

The effect of the ionophore A-23187 was tested on isolated secretory granules of rat parotid gland. The ionophore caused extensive release of calcium from the granules without effecting release of amylase or other secretory proteins. It is therefore concluded that the role of calcium in the granules is probably not that of a stabilizing agent.

Calcium Uptake in Rat Parotid Gland Secretory Granules

1991 ◽  
Vol 70 (12) ◽  
pp. 1524-1527 ◽  
Author(s):  
J.E. Porter ◽  
P. Cheung ◽  
F.J. Dowd
Keyword(s):  
Parotid Gland ◽  
Calcium Uptake ◽  
Secretory Granules ◽  
Uptake Mechanism ◽  
Atpase Inhibitors ◽  
Rat Parotid Gland ◽  
Disulphonic Acid ◽  
Rat Parotid ◽  
Hydrolysis Of ◽  
Isolated Rat

45Ca2+ uptake in isolated rat parotid secretory granules was examined in the presence of oxalate. Uptake of calcium was dependent on time, with the maximum occurring at 15 min. The uptake of calcium was dependent on adenosine-5'-triphosphate (ATP), and substitution of ATP with B,g-methylene-ATP did not stimulate calcium uptake. Enzyme marker analysis indicated that mitochondria accounted for no greater than 3.0 ±0.2% of the observed ATP-dependent calcium uptake. Calcium uptake was blocked by the ATPase inhibitors tributyltin, IC 50 = 12.2 ±0.6 nmol/L and 4-acetamido-4'-isothiocyano-2,2'-stilbene disulphonic acid (SITS), IC50 = 3.0 ±0.3 (μmol/L. These results indicate that in the parotid secretory granule there is a calcium uptake mechanism that is dependent on the hydrolysis of ATP and is suppressed by two inhibitors of granule ATPase.

The Role of Estrogen on Rat Parotid Gland after Menopause

2012 ◽  
Vol 147 (2_suppl) ◽  
pp. P182-P182
Author(s):  
Arzu Tatlıpınar ◽  
Cagatay Oysu ◽  
Ünal Uslu ◽  
Alev Yiğit ◽  
Ayş egül Verim
Keyword(s):  
Parotid Gland ◽  
Rat Parotid Gland ◽  
Rat Parotid

The role of protein kinase C on amylase secretion from rat parotid gland

1988 ◽  
Vol 150 (3) ◽  
pp. 1309-1314 ◽  
Author(s):  
Hiromi Shimomura ◽  
Akane Terada ◽  
Yoshiaki Hashimoto ◽  
Thomas R. Soderling
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Parotid Gland ◽  
Amylase Secretion ◽  
Kinase C ◽  
Rat Parotid Gland ◽  
Rat Parotid
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