scholarly journals Elena Gracheva: Ion channels run hot and cold

2015 ◽  
Vol 209 (6) ◽  
pp. 778-779 ◽  
Author(s):  
Caitlin Sedwick
Keyword(s):  
Ion Channels ◽  
Molecular Basis ◽  
Evolutionary Origins

Gracheva studies the molecular basis and evolutionary origins of hibernation.

scholarly journals Common evolutionary origins of mechanosensitive ion channels in Archaea, Bacteria and cell-walled Eukarya

Archaea ◽  
2002 ◽  
Vol 1 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Anna Kloda ◽  
Boris Martinac
Keyword(s):  
Ion Channels ◽  
Lipid Bilayer ◽  
Sequence Homology ◽  
Eukaryotic Cell ◽  
Physiological Functions ◽  
Ancestral Origin ◽  
Gating Mechanisms ◽  
Evolutionary Origins ◽  
Osmotic Challenge ◽  
Small Conductance

The ubiquity of mechanosensitive (MS) channels triggered a search for their functional homologs in Archaea. Archaeal MS channels were found to share a common ancestral origin with bacterial MS channels of large and small conductance, and sequence homology with several proteins that most likely function as MS ion channels in prokaryotic and eukaryotic cell-walled organisms. Although bacterial and archaeal MS channels differ in conductive and mechanosensitive properties, they share similar gating mechanisms triggered by mechanical force transmitted via the lipid bilayer. In this review, we suggest that MS channels of Archaea can bridge the evolutionary gap between bacterial and eukaryotic MS channels, and that MS channels of Bacteria, Archaea and cell-walled Eukarya may serve similar physiological functions and may have evolved to protect the fragile cellular membranes in these organisms from excessive dilation and rupture upon osmotic challenge.

scholarly journals Molecular Basis for Inhibition of Acid-Sensing Ion Channels by Ibuprofen

2017 ◽  
Vol 112 (3) ◽  
pp. 420a
Author(s):  
Timothy Lynagh ◽  
Jose L. Romero-Rojo ◽  
Stephan A. Pless
Keyword(s):  
Ion Channels ◽  
Molecular Basis ◽  
Acid Sensing Ion Channels

scholarly journals Divergent Evolution of Eukaryotic CC- and A-Adding Enzymes

2020 ◽  
Vol 21 (2) ◽  
pp. 462 ◽  
Author(s):  
Lieselotte Erber ◽  
Paul Franz ◽  
Heike Betat ◽  
Sonja Prohaska ◽  
Mario Mörl
Keyword(s):  
Schizosaccharomyces Pombe ◽  
Molecular Basis ◽  
Divergent Evolution ◽  
Full Activity ◽  
Flexible Loop ◽  
Evolutionary Origins ◽  
Loop Region ◽  
Restricted Activity ◽  
Salpingoeca Rosetta

Synthesis of the CCA end of essential tRNAs is performed either by CCA-adding enzymes or as a collaboration between enzymes restricted to CC- and A-incorporation. While the occurrence of such tRNA nucleotidyltransferases with partial activities seemed to be restricted to Bacteria, the first example of such split CCA-adding activities was reported in Schizosaccharomyces pombe. Here, we demonstrate that the choanoflagellate Salpingoeca rosetta also carries CC- and A-adding enzymes. However, these enzymes have distinct evolutionary origins. Furthermore, the restricted activity of the eukaryotic CC-adding enzymes has evolved in a different way compared to their bacterial counterparts. Yet, the molecular basis is very similar, as highly conserved positions within a catalytically important flexible loop region are missing in the CC-adding enzymes. For both the CC-adding enzymes from S. rosetta as well as S. pombe, introduction of the loop elements from closely related enzymes with full activity was able to restore CCA-addition, corroborating the significance of this loop in the evolution of bacterial as well as eukaryotic tRNA nucleotidyltransferases. Our data demonstrate that partial CC- and A-adding activities in Bacteria and Eukaryotes are based on the same mechanistic principles but, surprisingly, originate from different evolutionary events.

scholarly journals Molecular basis for heat desensitization of TRPV1 ion channels

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Lei Luo ◽  
Yunfei Wang ◽  
Bowen Li ◽  
Lizhen Xu ◽  
Peter Muiruri Kamau ◽  
...  
Keyword(s):  
Ion Channels ◽  
Molecular Basis

scholarly journals Molecular Basis for Ion Selectivity in Heteromeric Acid-Sensing Ion Channels

2019 ◽  
Vol 116 (3) ◽  
pp. 110a
Author(s):  
Zeshan P. Sheikh ◽  
Timothy Lynagh ◽  
Emelie Flood ◽  
Celine Boiteux ◽  
Toby W. Allen ◽  
...  
Keyword(s):  
Ion Channels ◽  
Molecular Basis ◽  
Ion Selectivity ◽  
Acid Sensing Ion Channels

scholarly journals Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Timothy Lynagh ◽  
Robin N. Beech ◽  
Maryline J. Lalande ◽  
Kevin Keller ◽  
Brett A. Cromer ◽  
...  
Keyword(s):  
Ion Channels ◽  
Molecular Basis ◽  
Convergent Evolution ◽  
Gated Ion Channels ◽  
Ligand Gated Ion Channels

scholarly journals Molecular basis of permeation in voltage-gated ion channels.

1993 ◽  
Vol 72 (3) ◽  
pp. 491-496 ◽  
Author(s):  
G F Tomaselli ◽  
P H Backx ◽  
E Marban
Keyword(s):  
Ion Channels ◽  
Molecular Basis ◽  
Voltage Gated ◽  
Voltage Gated Ion Channels ◽  
Gated Ion Channels
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