A sharp end to sugary Wingless travels
Keyword(s):
Drosophila melanogaster follicle stem cells are controlled by Wingless (Wg) ligands secreted 50 µm away, raising the question of how long-distance Wg spreading occurs. In this issue of JCB, Wang and Page-McCaw (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201403084) demonstrate a potential mechanism by which the heparan sulfate proteoglycan Dally-like (Dlp) promotes Wg travel, whereas matrix Mmp2 (Metalloproteinase 2) impedes it by inactivating Dlp.
Keyword(s):
Keyword(s):
Keyword(s):
2016 ◽
Vol 13
(4)
◽
pp. 528-533
◽
1989 ◽
Vol 264
(29)
◽
pp. 17551-17558
◽
1990 ◽
Vol 265
(32)
◽
pp. 19980-19989
1997 ◽
Vol 38
(12)
◽
pp. 2465-2472
◽