scholarly journals It's HIP to be a hub

2005 ◽  
Vol 170 (2) ◽  
pp. 169-171 ◽  
Author(s):  
Manuela Vecchi ◽  
Pier Paolo Di Fiore
Keyword(s):  
Network Theory ◽  
Transcriptional Activity ◽  
Hormone Receptors ◽  
Nuclear Hormone Receptors ◽  
Interacting Protein ◽  
Endocytic Protein ◽  
Huntingtin Interacting Protein 1 ◽  
Huntingtin Interacting Protein ◽  
Endocytic Proteins

Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional “territories:” a possibility with important physiological and pathological implications.

scholarly journals Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

2005 ◽  
Vol 170 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Ian G. Mills ◽  
Luke Gaughan ◽  
Craig Robson ◽  
Theodora Ross ◽  
Stuart McCracken ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Hormone Receptors ◽  
Nuclear Translocation ◽  
Coiled Coil ◽  
Adaptor Proteins ◽  
Cellular Transformation ◽  
Interacting Protein ◽  
Response Elements ◽  
Huntingtin Interacting Protein 1 ◽  
Huntingtin Interacting Protein

Internalization of activated receptors regulates signaling, and endocytic adaptor proteins are well-characterized in clathrin-mediated uptake. One of these adaptor proteins, huntingtin interacting protein 1 (HIP1), induces cellular transformation and is overexpressed in some prostate cancers. We have discovered that HIP1 associates with the androgen receptor through a central coiled coil domain and is recruited to DNA response elements upon androgen stimulation. HIP1 is a novel androgen receptor regulator, significantly repressing transcription when knocked down using a silencing RNA approach and activating transcription when overexpressed. We have also identified a functional nuclear localization signal at the COOH terminus of HIP1, which contributes to the nuclear translocation of the protein. In conclusion, we have discovered that HIP1 is a nucleocytoplasmic protein capable of associating with membranes and DNA response elements and regulating transcription.

scholarly journals Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain

2000 ◽  
Vol 275 (52) ◽  
pp. 41299-41308 ◽  
Author(s):  
Abigail S. Hackam ◽  
Ayman S. Yassa ◽  
Roshni Singaraja ◽  
Martina Metzler ◽  
Claire-Anne Gutekunst ◽  
...  
Keyword(s):  
Interacting Protein ◽  
Effector Domain ◽  
Death Effector Domain ◽  
Huntingtin Interacting Protein 1 ◽  
Death Effector ◽  
Huntingtin Interacting Protein

scholarly journals Aberrant Huntingtin Interacting Protein 1 in Lymphoid Malignancies

2007 ◽  
Vol 67 (18) ◽  
pp. 8923-8931 ◽  
Author(s):  
Sarah V. Bradley ◽  
Mitchell R. Smith ◽  
Teresa S. Hyun ◽  
Peter C. Lucas ◽  
Lina Li ◽  
...  
Keyword(s):  
Interacting Protein ◽  
Lymphoid Malignancies ◽  
Huntingtin Interacting Protein 1 ◽  
Huntingtin Interacting Protein

Huntingtin interacting protein 1 can regulate neurogenesis inDrosophila

2008 ◽  
Vol 28 (3) ◽  
pp. 599-609 ◽  
Author(s):  
Justin N. Moores ◽  
Sophie Roy ◽  
Donald W. Nicholson ◽  
Brian E. Staveley
Keyword(s):  
Interacting Protein ◽  
Huntingtin Interacting Protein 1 ◽  
Huntingtin Interacting Protein
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