scholarly journals Regulation of nucleocytoplasmic trafficking by cell adhesion receptors and the cytoskeleton

2001 ◽  
Vol 155 (2) ◽  
pp. 187-192 ◽  
Author(s):  
Andrew E. Aplin ◽  
R.L. Juliano
Keyword(s):  
Cell Adhesion ◽  
Growth Factors ◽  
Adhesion Molecule ◽  
Nuclear Import ◽  
Cell Adhesion Molecule ◽  
Signaling Cascades ◽  
Signaling Proteins ◽  
Nucleocytoplasmic Trafficking ◽  
Adhesion Receptors ◽  
Import And Export

It has become widely accepted that adhesion receptors can either directly activate, or significantly modulate, many of the signaling cascades initiated by circulating growth factors. An interesting recent development is the realization that adhesion receptors and their cytoskeletal partners can regulate the trafficking of signaling proteins between the cytoplasm and nucleus. Cell adhesion molecule control of nucleocytoplasmic trafficking allows adhesion to influence many cell decisions, and highlights the diversity of nuclear import and export mechanisms.

scholarly journals Long-Term Quality Control of the Cytokine & Growth Factors and Cell Adhesion Molecule Arrays at the Randox Evidence Investigator

2009 ◽  
Vol 28 (4) ◽  
pp. 300-304 ◽  
Author(s):  
Johannes van Pelt ◽  
Fred Romijn
Keyword(s):  
Quality Control ◽  
Cell Adhesion ◽  
Growth Factors ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Control Level ◽  
Low Grade ◽  
Coefficients Of Variation ◽  
Promising Development

Long-Term Quality Control of the Cytokine & Growth Factors and Cell Adhesion Molecule Arrays at the Randox Evidence InvestigatorMulti component assays are a promising development in laboratory medicine. Reproducibility and standardization of the used technology is crucial for the quality of the results. In our laboratory several studies were carried out in a period of more than two years using the Randox Evidence Investigator. We applied the Cytokine & Growth Factors and Cell Adhesion Molecule Array from which reference values could be obtained. Cytokines are not useful in low grade inflammation or in normal persons as the levels are too low to detect. However growth factors and cell adhesion molecules could be determined in those studies. Outcomes with the arrays were compared with conventional assays such as ELISA. The correlations of IL-6 and IL-10 were very good and that of s-ICAM acceptable. Inter-assay coefficients of variation could be calculated by using the same control level material during those years. The system turned out to be easy to handle and very stable over a long period of time with CV's of about 8-12%. The results obtained are not dependent of the lot number of the arrays or apparatus as two different apparatus gave same outcomes.

622: Von Hippel-Lindau Inactivation Downregulates the Cell-Cell Adhesion Molecule E Cadherin in Renal Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 170-170
Author(s):  
Maxine G. Tran ◽  
Miguel A. Esteban ◽  
Peter D. Hill ◽  
Ashish Chandra ◽  
Tim S. O'Brien ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Von Hippel Lindau ◽  
E Cadherin ◽  
Cell Cell

Differential Expression of Platelet-Endothelial Cell Adhesion Molecule-1 (PECAM-1) in Murine Tissues

1998 ◽  
Vol 5 (2-3) ◽  
pp. 179-188 ◽  
Author(s):  
MICHAEL J EPPIHIMER ◽  
J A N I C E RUSELL ◽  
R O B E R T LANGLEY ◽  
G I N A VALLIEN ◽  
DONALD C ANDERSON ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Differential Expression ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Endothelial Cell Adhesion Molecule ◽  
Platelet Endothelial Cell Adhesion ◽  
Cell Adhesion Molecule 1 ◽  
Endothelial Cell Adhesion
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