Mild and Efficient Synthesis of Carboxylic Acid Anhydrides from Carboxylic Acids and Triazine Coupling Reagents

2004 ◽  
Vol 34 (18) ◽  
pp. 3349-3358 ◽  
Author(s):  
Zbigniew J. Kamiñski ◽  
Beata Kolesiñska ◽  
Marcinkowska Małgorzata
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Efficient Synthesis ◽  
Coupling Reagents ◽  
Acid Anhydrides

A Schiff base-modified silver catalyst for efficient fixation of CO2 as carboxylic acid at ambient pressure

2017 ◽  
Vol 19 (9) ◽  
pp. 2080-2085 ◽  
Author(s):  
Zhilian Wu ◽  
Lei Sun ◽  
Qinggang Liu ◽  
Xiaofeng Yang ◽  
Xue Ye ◽  
...  
Keyword(s):  
Schiff Base ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Ambient Pressure ◽  
Terminal Alkynes ◽  
Silver Catalyst ◽  
Efficient Synthesis

A Schiff base-modified silver catalyst was developed for the direct carboxylation of terminal alkynes with CO2, enabling the efficient synthesis of valuable alkynyl carboxylic acids.

Isocarbostyrils. II. The Conversion of 2-Methyl-4-acyl-5-nitroisocarbostyrils to 2-Substituted Indole-4-carboxylic Acids

1971 ◽  
Vol 49 (17) ◽  
pp. 2797-2802 ◽  
Author(s):  
D. E. Horning ◽  
G. Lacasse ◽  
J. M. Muchowski
Keyword(s):  
Sulfuric Acid ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Alkaline Hydrolysis ◽  
Mannich Reaction ◽  
Reductive Cyclization ◽  
Acid Catalyzed ◽  
Acid Anhydrides ◽  
Hydrolysis Of ◽  
Derivatives Of

The sulfuric acid catalyzed acylation of 2-methyl-5-nitroisocarbostyril with carboxylic acid anhydrides gave the corresponding 4-acylated derivatives 3, which underwent reductive cyclization to 2-substituted derivatives of 4-methyl-1,3,4,5-tetrahydropyrrolo[4.3.2.de]isoquinolin-5-one (4). Alkaline hydrolysis of the six-membered lactam in 4 was accompanied by a retro-Mannich reaction to produce 2-substituted indole-4-carboxylic acids in about 40 % overall yield from 3.

Silver-Promoted Regioselective Oxidative Decarboxylative C–H Alkylation of Phenanthridines with Carboxylic Acids

Synthesis ◽  
2019 ◽  
Vol 52 (02) ◽  
pp. 239-245
Author(s):  
Tianyin Huang ◽  
Yang Yu ◽  
Hui Wang ◽  
Yifan Lin ◽  
Yurui Ma ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Efficient Synthesis ◽  
One Pot ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
The Given

A novel oxidative decarboxylative C–H alkylation of phenanthridines with carboxylic acids was developed for the efficient synthesis of multi-substituted phenanthridine derivatives. The given method features easy availability of starting materials, high regioselectivity, and mild conditions. Furthermore, a one-pot synthesis of multi-substituted phenanthridine derivatives was realized by the reaction of biphenyl isocyanides and carboxylic acid.

Reactions of Chromyl Chloride with Carboxylic Acids and Carboxylic Acid Anhydrides

1985 ◽  
Vol 40 (2) ◽  
pp. 247-250 ◽  
Author(s):  
Ramesh Kapoor ◽  
Pratibha Kapoor ◽  
Ramneek Sharma
Keyword(s):  
Magnetic Susceptibility ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Magnetic Moment ◽  
Antiferromagnetic Coupling ◽  
Chromyl Chloride ◽  
Polar Organic Solvents ◽  
Uv Visible ◽  
Acid Anhydrides ◽  
Polymeric Structures

Abstract Chromyl Chloride reacts with carboxylic acids [RCOOH where R = C2H5, n-C3H7, CH2CI, CHCl2 and CCI3] to give reduced chromium(III) carboxylates, [Cr3 O(OOCR)6 (H2O)3 ]Cl. Magnetic susceptibility, UV-visible and IR measurements are all consistent with their trinuclear basic structures. Reactions of chromyl chloride with carboxylic acid anhydrides [(RCO)2O where R = CH3 , C2H5 and n-C3H7 ] give dinuclear oxo-bridged complexes of the type, [Cr2O(OOOCR)3 ]Cl. These compounds behave as non-electrolytes in polar organic solvents. IR spectra suggest the presence of bridging carboxylato groups containing Cr-O -Cr chains. Their low magnetic moment values suggest polymeric structures exhibiting antiferromagnetic coupling between Cr atoms.

Synthesis of 3-(Cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8- carboxylic Acids Via an Efficient Three-component Condensation Reaction between Cyclohexylisocyanide and 2-Aminopyridine-3-carboxylic Acid in the Presence of Aromatic Aldehyde

2018 ◽  
Vol 21 (4) ◽  
pp. 298-301 ◽  
Author(s):  
Ghasem Marandi
Keyword(s):  
Biological Sciences ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
High Performance ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
New Materials ◽  
One Pot ◽  
High Yields ◽  
Benzaldehyde Derivatives

Aim and Objective: The reaction of cyclohexylisocyanide and 2-aminopyridine-3- carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2- arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. Material and Methods: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis. Results: In continuation of our attempts to develop simple one-pot routes for the synthesis of 3- (cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids, aromatic aldehydes with divers substituted show a high performance. Conclusion: In conclusion, this study introduces the art of combinatorial chemistry using a simple one-pot procedure for the synthesis of new materials which are interesting compounds in medicinal and biological sciences.

scholarly journals Propylphosphonic acid anhydride–mediated amidation of Morita–Baylis–Hillman–derived indolizine-2-carboxylic acids

2021 ◽  
pp. 174751982098715
Author(s):  
Khethobole C Sekgota ◽  
Michelle Isaacs ◽  
Heinrich C Hoppe ◽  
Ronnett Seldon ◽  
Digby F Warner ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Coupling Agent ◽  
Methyl Esters ◽  
Acid Anhydride

Propylphosphonic acid anhydride has been successfully used as a coupling agent in the synthesis of a series of indolizine-2-carboxamido derivatives from indolizine-2-carboxylic acid and its 3-acetylated analogue. The acid substrates were obtained by saponification of the corresponding methyl esters produced, in turn, selectively and efficiently, by time-controlled cyclisation of a single Morita–Baylis–Hillman adduct. Various amino and hydrazino compounds with medicinal potential have been used to prepare indolizine-2-carboxamido and hydrazido derivatives.

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