SYNTHESIS OF 3′-UREIDOADENOSINE ANALOGUES AND THEIR BINDING AFFINITY TO THE A3 ADENOSINE RECEPTOR

2005 ◽  
Vol 24 (5-7) ◽  
pp. 1119-1121 ◽  
Author(s):  
Moon Woo Chun ◽  
Hyouk Woo Lee ◽  
Ae Yil Kim ◽  
Myong Jung Kim ◽  
Hea Ok Kim ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Adenosine Receptor ◽  
A3 Adenosine Receptor

scholarly journals Synthesis of 3′-ureidoadenosines and their high binding affinity at the mutant A3 adenosine receptor

2005 ◽  
Vol 49 (1) ◽  
pp. 105-106 ◽  
Author(s):  
Ae Yil Kim ◽  
Hea Ok Kim ◽  
Myoung Jung Kim ◽  
Moon Woo Chun ◽  
Kang Man Lee ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Adenosine Receptor ◽  
High Binding ◽  
A3 Adenosine Receptor ◽  
High Binding Affinity

ChemInform Abstract: Synthesis of 3′-(Ureido)adenosine Derivatives and Their High Binding Affinity at the Mutant A3 Adenosine Receptor

ChemInform ◽  
2008 ◽  
Vol 39 (29) ◽  
Author(s):  
Ae Yil Kim ◽  
Hea Ok Kim ◽  
Myoung Jung Kim ◽  
Moon Woo Chun ◽  
Kang Man Lee ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Adenosine Receptor ◽  
High Binding ◽  
A3 Adenosine Receptor ◽  
Adenosine Derivatives ◽  
High Binding Affinity

scholarly journals Design and Synthesis of 2,6-Disubstituted-4′-Selenoadenosine-5′-N,N-Dimethyluronamide Derivatives as Human A3 Adenosine Receptor Antagonists

2021 ◽  
Vol 14 (4) ◽  
pp. 363
Author(s):  
Hongseok Choi ◽  
Kenneth A. Jacobson ◽  
Jinha Yu ◽  
Lak Shin Jeong
Keyword(s):  
Binding Affinity ◽  
Adenosine Receptor ◽  
Functional Assay ◽  
Antagonist Activity ◽  
Methyl Group ◽  
Design And Synthesis ◽  
Selective Antagonists ◽  
A3 Adenosine Receptor ◽  
High Binding Affinity

A new series of 4′-selenoadenosine-5′-N,N-dimethyluronamide derivatives as highly potent and selective human A3 adenosine receptor (hA3AR) antagonists, is described. The highly selective A3AR agonists, 4′-selenoadenosine-5′-N-methyluronamides were successfully converted into selective antagonists by adding a second N-methyl group to the 5′-uronamide position. All the synthesized compounds showed medium to high binding affinity at the hA3AR. Among the synthesized compounds, 2-H-N6-3-iodobenzylamine derivative 9f exhibited the highest binding affinity at hA3AR. (Ki = 22.7 nM). The 2-H analogues generally showed better binding affinity than the 2-Cl analogues. The cAMP functional assay with 2-Cl-N6-3-iodobenzylamine derivative 9l demonstrated hA3AR antagonist activity. A molecular modelling study suggests an important role of the hydrogen of 5′-uronamide as an essential hydrogen bonding donor for hA3AR activation.

scholarly journals Regio- and stereoselective synthesis of truncated 3′-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor

2011 ◽  
Vol 9 (20) ◽  
pp. 6955 ◽  
Author(s):  
Mun Ju Choi ◽  
Girish Chandra ◽  
Hyuk Woo Lee ◽  
Xiyan Hou ◽  
Won Jun Choi ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Adenosine Receptor ◽  
Stereoselective Synthesis ◽  
A3 Adenosine Receptor

Recent Advances on QSAR-Based Profiling of Agonist and Antagonist A3 Adenosine Receptor Ligands

2013 ◽  
Vol 13 (9) ◽  
pp. 1048-1068 ◽  
Author(s):  
Changliang Deng ◽  
Feng Luan ◽  
Maykel Cruz- Monteagudo ◽  
Fernanda Borges ◽  
M. Natalia D. S. Cordeiro
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
Recent Advances ◽  
A3 Adenosine Receptor ◽  
Agonist And Antagonist ◽  
Adenosine Receptor Ligands

scholarly journals CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver

2011 ◽  
Vol 226 (9) ◽  
pp. 2438-2447 ◽  
Author(s):  
S. Cohen ◽  
S.M. Stemmer ◽  
G. Zozulya ◽  
A. Ochaion ◽  
R. Patoka ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Adenosine Receptor Agonist ◽  
A3 Adenosine Receptor ◽  
Anti Inflammatory
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