The Prevalence of Reversible Airflow Obstruction and/or Methacholine Hyperreactivity in Random Adult Asthma Patients Identified by Administrative Data

2005 ◽  
Vol 42 (3) ◽  
pp. 213-220 ◽  
Author(s):  
Eric Macy ◽  
Michael Schatz ◽  
Carlene Gibbons ◽  
Robert Zeiger
Keyword(s):  
Administrative Data ◽  
Airflow Obstruction ◽  
Adult Asthma ◽  
Asthma Patients ◽  
Reversible Airflow Obstruction

scholarly journals Persistent Airflow Obstruction in Young Adult Asthma Patients

2012 ◽  
Vol 61 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Kiyoshi Sekiya ◽  
Masami Taniguchi ◽  
Yuma Fukutomi ◽  
Chihiro Mitsui ◽  
Hidenori Tanimoto ◽  
...  
Keyword(s):  
Young Adult ◽  
Airflow Obstruction ◽  
Adult Asthma ◽  
Asthma Patients

Relationship Between Psychosocial Stressor and Asthma Control in Adult Asthma Patients at Depok Hospital, West Java

2020 ◽  
Author(s):  
Hasnah Viviana ◽  
◽  
Erna Harfiani ◽  
◽  
Keyword(s):  
Asthma Control ◽  
Clinical Symptoms ◽  
Control Level ◽  
Airflow Obstruction ◽  
Psychosocial Stressors ◽  
Psychosocial Stressor ◽  
West Java ◽  
Cross Sectional ◽  
Adult Asthma ◽  
Asthma Patients

ABSTRACT Background: Asthma is a reversible airflow obstruction developed by genetic and environ-mental factors. Several studies revealed that stress could exacerbate the clinical symptoms in patients with asthma. This study aimed to determine the relationship between psychosocial stressors and the asthma control level in adult asthma patients at pulmonology polyclinic, Depok Hospital, West Java. Subjects and Method: This was a cross-sectional study conducted at pulmonology polyclinic, Depok Hospital, West Java in 2019. A total of 58 adult asthma patients was selected with consecutive sampling. The dependent variable was the asthma control. The independent variable was the level of the psychosocial stressor. The data were collected using asthma control questionnaires and the Holmes-Rahe Scale for calculating the score of stress events. Data were analyzed by chi-square. Results: The majority of adult asthma patients had moderate to severe psychosocial stressors (63.8%) and partial to fully controlled asthma (53.4%). Level of psychosocial stressor reduced the level of asthma control, and it was statistically significant (p <0.001). Conclusion: The level of psychosocial stressor reduces the level of asthma control. Keywords: bronchial asthma, psychosocial stressor, level of controlled Correspondence: Erna Harfiani. Department of Pharmacology, Faculty of Medicine, UPN Veteran Jakarta. Jl RS Fatmawati Pondok Labu Jakarta Selatan, 12450. Email: [email protected]. Mobile: +6281585042313. DOI: https://doi.org/10.26911/the7thicph.05.31

scholarly journals Effects of Air Pollutant Exposure on Exacerbation Severity in Asthma Patients with or without Reversible Airflow Obstruction

2021 ◽  
Vol Volume 14 ◽  
pp. 1117-1127
Author(s):  
Wei Fang ◽  
Yu Zhang ◽  
Sinian Li ◽  
Aiming Liu ◽  
Yin Jiang ◽  
...  
Keyword(s):  
Airflow Obstruction ◽  
Air Pollutant ◽  
Asthma Patients ◽  
Reversible Airflow Obstruction

scholarly journals Mechanisms of Remodeling in Asthmatic Airways

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Adrian Shifren ◽  
Chad Witt ◽  
Chandrika Christie ◽  
Mario Castro
Keyword(s):  
Airway Hyperresponsiveness ◽  
Structural Changes ◽  
Airway Remodeling ◽  
Airflow Obstruction ◽  
Asthma Treatment ◽  
Airway Wall ◽  
Lung Function Decline ◽  
Airway Wall Thickness ◽  
Asthma Patients ◽  
Reversible Airflow Obstruction

Asthma is a chronic inflammatory airway disorder characterized by airway hyperresponsiveness and reversible airflow obstruction. Subgroups of asthma patients develop airflow obstruction that is irreversible or only partially reversible and experience an accelerated rate of lung function decline. The structural changes in the airways of these patients are referred to as airway remodeling. All elements of the airway wall are involved, and remodeled airway wall thickness is substantially increased compared to normal control airways. Airway remodeling is thought to contribute to the subphenotypes of irreversible airflow obstruction and airway hyperresponsiveness, and it has been associated with increased disease severity. Reversal of remodeling is therefore of paramount therapeutic importance, and mechanisms responsible for airway remodeling are feasible therapeutic targets for asthma treatment. This paper will focus on our current understanding of the mechanisms of airway remodeling in asthma and potential targets for future intervention.

scholarly journals Regulation of Eosinophilia in Asthma—New Therapeutic Approaches for Asthma Treatment

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 817
Author(s):  
Ruth P. Cusack ◽  
Christiane E. Whetstone ◽  
Yanqing Xie ◽  
Maral Ranjbar ◽  
Gail M. Gauvreau
Keyword(s):  
Drug Targets ◽  
Airflow Obstruction ◽  
Chronic Inflammatory Disease ◽  
Therapeutic Approaches ◽  
Eosinophilic Asthma ◽  
Airway Eosinophilia ◽  
Gm Csf ◽  
New Therapeutic Approaches ◽  
Cellular Apoptosis ◽  
Reversible Airflow Obstruction

Asthma is a complex and chronic inflammatory disease of the airways, characterized by variable and recurring symptoms, reversible airflow obstruction, bronchospasm, and airway eosinophilia. As the pathophysiology of asthma is becoming clearer, the identification of new valuable drug targets is emerging. IL-5 is one of these such targets because it is the major cytokine supporting eosinophilia and is responsible for terminal differentiation of human eosinophils, regulating eosinophil proliferation, differentiation, maturation, migration, and prevention of cellular apoptosis. Blockade of the IL-5 pathway has been shown to be efficacious for the treatment of eosinophilic asthma. However, several other inflammatory pathways have been shown to support eosinophilia, including IL-13, the alarmin cytokines TSLP and IL-33, and the IL-3/5/GM-CSF axis. These and other alternate pathways leading to airway eosinophilia will be described, and the efficacy of therapeutics that have been developed to block these pathways will be evaluated.

Developing Episodes of Care for Adult Asthma Patients: A Cautionary Tale*†

1998 ◽  
Vol 13 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Amy K. Rosen ◽  
Robert L. Houchens ◽  
Teresa B. Gibson ◽  
Allison Mayer-Oakes
Keyword(s):  
Cautionary Tale ◽  
Adult Asthma ◽  
Asthma Patients ◽  
Episodes Of Care

P111 CD-14 gene polymorphism in adult asthma patients with eosinophilic versus neutrophilic sputum in crimea

2016 ◽  
Vol 117 (5) ◽  
pp. S53
Author(s):  
Y. Bisyuk ◽  
A. Kurchenko ◽  
O. Akhtemiichuk ◽  
A. Dubovyi ◽  
L. DuBuske
Keyword(s):  
Gene Polymorphism ◽  
Adult Asthma ◽  
Asthma Patients
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