Relationship Between Vascular Endothelial Growth Factor and Angiopoietin-2 in Asthmatics Before and After Inhaled Beclomethasone Therapy

2004 ◽  
Vol 42 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Saeko Nomura ◽  
Hiroshi Kanazawa ◽  
Kazuto Hirata ◽  
Hiroshi Iwao ◽  
Junichi Yoshikawa
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Before And After ◽  
Angiopoietin 2 ◽  
Endothelial Growth Factor

scholarly journals Clinical Significance of Serum Levels of Vascular Endothelial Growth Factor, Angiopoietin-1, and Angiopoietin-2 in Patients with Rheumatoid Arthritis

2010 ◽  
Vol 37 (6) ◽  
pp. 1121-1128 ◽  
Author(s):  
DAITARO KUROSAKA ◽  
KENICHIRO HIRAI ◽  
MAKIKO NISHIOKA ◽  
YUKIO MIYAMOTO ◽  
KEN YOSHIDA ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Serum Levels ◽  
Vascular Endothelial ◽  
Angiopoietin 2 ◽  
Serum Crp ◽  
Endothelial Growth Factor ◽  
Vegf Level ◽  
Angiopoietin 1

Objective.To evaluate the clinical significance of serum levels of vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), and angiopoietin-2 (Ang-2) in patients with rheumatoid arthritis (RA).Methods.The subjects were 70 patients with RA. Serum VEGF, Ang-1, and Ang-2 levels were determined by ELISA. As indices of disease activity, serum levels of C-reactive protein (CRP) and matrix metalloprotease (MMP)-3 were examined, and the 28-joint count Disease Activity Score (DAS28)-CRP was calculated. Power Doppler ultrasonography was performed in the bilateral wrists, elbows, shoulders, knees and ankles. The synovial blood flow signals were scored using a 3-grade scale (0–2), and the total of the scores in the 10 joints was regarded as the total signal score (TSS).Results.Serum VEGF level showed significant correlations with serum CRP and MMP-3 levels, DAS28-CRP, and TSS. Serum Ang-1 level showed significant correlations with serum MMP-3 level and DAS28-CRP. Serum Ang-2 level showed significant correlations with serum CRP level and TSS.Conclusion.The serum VEGF level is important as an index of the activity of RA based on angiogenesis and a prognostic factor regarding joint destruction. Serum Ang-1 level may be useful as an index of sustained arthritis based on the maintenance of newly formed vessels. Serum Ang-2 level may reflect a state of marked angiogenesis.

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