Resorbable Polymeric Delivery Systems

2016 ◽  
pp. 6973-6985
Author(s):  
Julio San Romàn ◽  
Alberto Gallardo ◽  
Carlos Elvira ◽  
Blanca Vázquez ◽  
Gustavo A. Abraham
Keyword(s):  
Delivery Systems ◽  
Polymeric Delivery

Polymeric Delivery Systems for Macromolecules

1982 ◽  
pp. 95-105 ◽  
Author(s):  
ROBERT LANGER ◽  
DEAN S. T. HSIEH ◽  
LARRY BROWN
Keyword(s):  
Delivery Systems ◽  
Polymeric Delivery

NON-CONDENSING POLYMERIC GENE DELIVERY SYSTEMS: PRINCIPLES AND APPLICATIONS

Nano LIFE ◽  
2010 ◽  
Vol 01 (03n04) ◽  
pp. 219-237 ◽  
Author(s):  
SHARDOOL JAIN ◽  
HUSAIN ATTARWALA ◽  
MANSOOR AMIJI
Keyword(s):  
Gene Delivery ◽  
Targeted Delivery ◽  
Viral Vectors ◽  
Transfection Efficiency ◽  
Contemporary Literature ◽  
Delivery Systems ◽  
Expression Of Genes ◽  
Cytoplasmic Dna ◽  
Polymeric Delivery ◽  
Systemic Gene Delivery

Gene therapy holds tremendous promise in prevention and treatment of diseases as the approach is based on regulating the expression of genes that are responsible for pathological conditions. The biggest bottleneck for gene delivery has been the development of safe and efficacious delivery systems. Although non-viral vectors are considered as much safer options than their viral counterparts, they suffer from low transfection efficiency. In this review, we highlight the role of non-condensing polymeric delivery systems for oral and systemic gene delivery. Using evidence from contemporary literature, non-condensing polymeric microparticle and nanoparticle systems afford physical encapsulation of the nucleic acid construct and can be engineered for targeted delivery to tissues and cells. Additionally, these systems have shown less toxicity and afford sustained cytoplasmic DNA delivery for efficient nuclear uptake and transfection for both DNA vaccines and therapeutic genes.

Real Time Response Polymeric Delivery Systems

1991 ◽  
Vol 618 (1 Temporal Cont) ◽  
pp. 330-334 ◽  
Author(s):  
ROBERT LANGER ◽  
JOSEPH KOST
Keyword(s):  
Real Time ◽  
Delivery Systems ◽  
Time Response ◽  
Polymeric Delivery

scholarly journals Self-immolative linkers in polymeric delivery systems

2011 ◽  
Vol 2 (4) ◽  
pp. 773-790 ◽  
Author(s):  
Christopher A. Blencowe ◽  
Andrew T. Russell ◽  
Francesca Greco ◽  
Wayne Hayes ◽  
David W. Thornthwaite
Keyword(s):  
Delivery Systems ◽  
Polymeric Delivery
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