Physicochemical Characterization and In Vitro Release of Salicylic Acid from O/W Emulsions Prepared with Montanov 68®: Effect of Formulation Parameters

2004 ◽  
Vol 30 (9) ◽  
pp. 975-984 ◽  
Author(s):  
L. Baudonnet ◽  
J‐L. Grossiord ◽  
F. Rodriguez
Keyword(s):  
Salicylic Acid ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Formulation Parameters ◽  
Vitro Release

scholarly journals Phenobarbital loaded microemulsion: development, kinetic release and quality control

2016 ◽  
Vol 52 (2) ◽  
pp. 251-264 ◽  
Author(s):  
Kayo Alves Figueiredo ◽  
Jamilly Kelly Oliveira Neves ◽  
José Alexsandro da Silva ◽  
Rivelilson Mendes de Freitas ◽  
André Luis Menezes Carvalho
Keyword(s):  
Analytical Method ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Primary Stability ◽  
Isopropyl Myristate ◽  
Microemulsion System ◽  
Transdermal Application ◽  
Kinetics Of ◽  
Vitro Release

ABSTRACT This study aimed to obtain and characterize a microemulsion (ME) containing phenobarbital (PB). The PB was incorporated in the proportion of 5% and 10% in a microemulsion system containing Labrasol(r), ethanol, isopropyl myristate and purified water. The physicochemical characterization was performed and the primary stability of the ME was evaluated. An analytical method was developed using spectrophotometry in UV = 242 nm. The kinetics of the in vitro release (Franz model) of the ME and the emulsion (EM) containing PB was evaluated. The incorporation of PB into ME at concentrations of 5 and 10% did not change pH and resistance to centrifugation. There was an increase in particle size, a decrease of conductivity and a change in the refractive index in relation to placebo ME. The ME remained stable in preliminary stability tests. The analytical method proved to be specific, linear, precise, accurate and robust. Regarding the kinetics of the in vitro release, ME obtained an in vitro release profile greater than the EM containing PB. Thus, the obtained ME has a potential for future transdermal application, being able to compose a drug delivery system for the treatment of epilepsy.

Identification of critical formulation parameters affecting the in vitro release, permeation, and rheological properties of the acyclovir topical cream

2020 ◽  
Vol 590 ◽  
pp. 119914
Author(s):  
Nahid S. Kamal ◽  
Yellela S.R. Krishnaiah ◽  
Xiaoming Xu ◽  
Ahmed S. Zidan ◽  
Sameersingh Raney ◽  
...  
Keyword(s):  
Rheological Properties ◽  
In Vitro Release ◽  
Topical Cream ◽  
Formulation Parameters ◽  
Vitro Release

Formulation development of matrix type transdermal patches containing mefenamic acid: physicochemical characterization and in vitro release evaluation

2017 ◽  
Vol 148 (7) ◽  
pp. 1215-1222 ◽  
Author(s):  
Jirapornchai Suksaeree ◽  
Kotchakorn Piamsap ◽  
Supawan Paktham ◽  
Tichakorn Kenprom ◽  
Chaowalit Monton ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Formulation Development ◽  
Matrix Type ◽  
Transdermal Patches ◽  
Vitro Release

Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study

Nanomedicine ◽  
2020 ◽  
Vol 15 (30) ◽  
pp. 2955-2970
Author(s):  
Jin-Ying Wong ◽  
Zhao Yin Ng ◽  
Meenu Mehta ◽  
Shakti D Shukla ◽  
Jithendra Panneerselvam ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Inflammatory Markers ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
In Vitro Study ◽  
Physicochemical Characteristics ◽  
Vitro Study ◽  
Tnf Α ◽  
Vitro Release

Aim: In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma. Materials & methods: The formulation underwent various physicochemical characterization experiments, an in vitro release study, molecular simulations and was evaluated for in vitro anti-inflammatory activity. Results: Results showed that Nio-Curc had a mean particle size of 284.93 ± 14.27 nm, zeta potential of -46.93 and encapsulation efficacy of 99.62%, which demonstrates optimized physicochemical characteristics. Curcumin release in vitro could be sustained for up to 24 h. Additionally, Nio-Curc effectively reduced mRNA transcript expression of pro-inflammatory markers; IL-6, IL-8, IL-1β and TNF-α in immortalized human airway basal cell line (BCi-NS1.1). Conclusion: In this study, we have demonstrated that Nio-Curc mitigated the mRNA expression of pro-inflammatory markers in an in vitro study, which could be applied to treatment of asthma with further studies.

An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies

2017 ◽  
Vol 23 (2) ◽  
pp. 151-157
Author(s):  
Gisela Bevilacqua Rolfsen Ferreira da Silva ◽  
Alberto Camilo Alécio ◽  
Maria Virginia Costa Scarpa ◽  
Eryvaldo Socrates Tabosa do Egito ◽  
Rodrigo Sequinel ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Oil In Water ◽  
Release Studies ◽  
Vitro Release
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