The Effect of Particle Morphology on the Physical Stability of Pharmaceutical Powder Mixtures: The Effect of Surface Roughness of the Carrier on the Stability of Ordered Mixtures

2000 ◽  
Vol 26 (4) ◽  
pp. 365-373 ◽  
Author(s):  
Vidya Swaminathan ◽  
Dane O. Kildsig
Author(s):  
S. A. Nassar ◽  
T. S. Sun

An experimental study is presented in order to investigate the effect of surface roughness on the torque-tension relationship in bolted assemblies. Three levels of surface roughness are considered for the fastener underhead and the joint surface; namely, low, medium, and high levels of surface roughness. The study is conducted for two joint materials, two fastener classes, and for coarse and fine threads. In this study, the torque-tension data is expressed in terms of the value of the nut factor as well as its scatter. The effect of the number of tightenings on surface roughness and on the torque-tension relationship is investigated as well. The surface roughness is measured before tightening, and after each loosening using a WYKO optical profiling system. An M12 fastener is used in this study. Both fine and coarse threads and fastener material Classes 8.8 and 10.9 for M12 fasteners are used in this study. The torque-tension data is analyzed for both steel and aluminum joints. The safety and reliability of bolted assemblies are mainly determined by the level and the stability of the clamp load provided by the initial tightening of the threaded fastener. The value of initial clamp load, which is achieved by a specific level of tightening torque, is highly sensitive to the friction torque components. This study provides an insight into the reliability of the existing engineering practices for estimating the clamp load level from the tightening torque. Hence, the findings of the study would help enhance the reliability and the safety of bolted assemblies, especially in critical applications.


Shinku ◽  
1987 ◽  
Vol 30 (10) ◽  
pp. 793-798 ◽  
Author(s):  
Masao HIRASAKA ◽  
Masao HASHIBA ◽  
Toshiroh YAMASHINA

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2301
Author(s):  
Man Zhang ◽  
Bin Liang ◽  
Hongjun He ◽  
Changjian Ji ◽  
Tingting Cui ◽  
...  

Appropriate pretreatment of proteins and addition of xanthan gum (XG) has the potential to improve the stability of oil-in-water (O/W) emulsions. However, the factors that regulate the enhancement and the mechanism are still not clear, which restricts the realization of improving the emulsion stability by directional design of its structure. Therefore, the effects of whey protein micro-gel particles (WPMPs) and WPMPs-XG complexes on the stability of O/W emulsion were investigated in this article to provide theoretical support. WPMPs with different structures were prepared by pretreatment (controlled high-speed shear treatment of heat-set WPC gels) at pH 3.5–8.5. The impact of initial WPC structure and XG addition on Turbiscan Indexes, mean droplet size and the peroxide values of O/W emulsions was investigated. The results indicate that WPMPs and XG can respectively inhibit droplet coalescence and gravitational separation to improve the physical stability of WPC-stabilized O/W emulsions. The pretreatment significantly enhanced the oxidative stability of WPC-stabilized O/W emulsions. The addition of XG did not necessarily enhance the oxidative stability of O/W emulsions. Whether the oxidative stability of the O/W emulsion with XG is increased or decreased depends on the interface structure of the protein-XG complex. This study has significant implications for the development of novel structures containing lipid phases that are susceptible to oxidation.


2021 ◽  
Vol 194 ◽  
pp. 113785
Author(s):  
Pedro A. Martínez-Cartagena ◽  
Nobel O. Sierra-Vega ◽  
Bárbara B. Alvarado-Hernández ◽  
Rafael Méndez ◽  
Rodolfo J. Romañach

2021 ◽  
pp. 096739112110055
Author(s):  
Gunce Ozan ◽  
Meltem Mert Eren ◽  
Cansu Vatansever ◽  
Ugur Erdemir

Surface sealants are reported to ensure surface smoothness and improve the surface quality of composite restorations. These sealants should also reduce the bacterial adhesion on composite surfaces however, there is not much information regarding their performance on bulk-fill composite materials. The aim of this study was to evaluate the effect of surface sealant application on surface roughness and bacterial adhesion of various restorative materials. Disc-shaped samples were prepared from a compomer, a conventional composite and three bulk-fill composites. Specimens of each group were divided into two groups (n = 9): with/without surface sealant (Biscover LV, [BLV]). Surface roughness values were examined by profilometry and two samples of each group were examined for bacterial adhesion on a confocal laser scanning microscope (CLSM). Bacterial counts were calculated by both broth cultivation and microscopic images. Results were analyzed with one-way ANOVA and Bonferroni/Dunn tests. Following the BLV application, there was a decrease in the surface roughness values of all groups however, only Tetric N-Ceram Bulk and Beautifil-Bulk groups showed significantly smoother surfaces (p < 0.001). There were no significant differences among material groups without BLV application. Evaluating bacterial adhesion after BLV application, conventional composite had the lowest values among all followed by the compomer group. Beautifil-Bulk had significantly the highest bacterial adhesion (p < 0.05), followed by Tetric N-Ceram Bulk group. Without BLV application, there was no significant difference among bacterial adhesion values of groups (p > 0.05). CLSM images showed cell viability in groups. Bulk-fill composites showed higher bacterial adhesion than conventional composite and compomer materials. The surface sealant was found to be highly effective in lowering bacterial adhesion, but not so superior in smoothing the surfaces of restorative materials. So, surface sealants could be used on the restorations of patients with high caries risk.


2006 ◽  
Vol 58 (4) ◽  
pp. 176-186 ◽  
Author(s):  
N.M. Bujurke ◽  
N.B. Naduvinamani ◽  
Syeda Tasneem Fathima ◽  
S.S. Benchalli

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